In the late ‘80s Dr. Hargreaves invented a method to assess thermal pain sensation in unrestrained rodents by stimulating the single hind paw and thus allowing for unilateral/contralateral experiments. Ugo Basile made a science-grade instrument to perform this stimulation and automatically measure response, it became a gold-standard with more than 2,000 publications in 2022.

A thermal...

Touch sensitivity is traditionally tested with Von Frey filaments, which is a tedious and experimenter-dependent assay.

The Dynamic Plantar Aesthesiometer is a unique system, which fully automates the amount of force applied by an electromagnetic, silent motor exerting from 0 to 100 grams at a rate adjustable from 0 to 50 seconds.

When the animal responds, by withdrawing its...

Touch sensitivity in unrestrained animals is traditionally tested with Von Frey filaments, which is a tedious and experimenter-dependent assay.

The Electronic Von Frey system solves the multiple measurement (i.e. multiple filaments) issue and the experimenter bias by using a hand-held force sensor with a rigid metal. The scientist gradually increases the force applied to the animal...

Measures endurance, distance and speed. For studying behavioral, physiological, biochemical, and molecular responses to both acute exercise stress and chronic exercise training.

Original product by Ugo Basile is adaptable for use by rats or mice. Easy set up and control using touch screen. Automatic measurement of endurance, distance and speed. Shock grid for aversive stimulus (if...

The RotaRod is a simple test to assess motor function and coordination in rodents. Motor coordination or fatigue can be evaluated by measuring the time the animal stays on a rotating rod before falling. The Rod can rotate at constant, accelerating, rocking (back and forth) or through complex acceleration/deceleration ramps, thanks to the included PC software XPad.

The Ugo Basile...

Measures the weight distribution difference between an injured and unaffected hind paw of a mouse or rat. For the assessment of spontaneous pain in osteoarthritis, bone cancer, nerve injury and post-operative pain studies. Automatic operation reduces operator bias, optimizes repeatability and saves time. Easy to set up. Data visualization to monitor trends. Fast and easy cleaning...

Measures hypersensitivity to thermal (hot and cold) and/or mechanical stimulation of the orofacial area in rats (mouse adaptor available). For research into a wide range of pain conditions involving the trigeminal nerve.

High throughput with data recorded from up to 16 cages with ORO-Software. Real time data display. Non-invasive, respectful test. Comprehensive metrics and easy data...

The Thermal Place Preference test can be considered an evolution of the Hot/Cold plate test and it allows monitoring of temperature preferences by measuring the time spent in two compartments set at two different temperatures.

This two temperature nociception test can be used in a mouse or rat and is composed of a standard hot/cold plate and of an hot plate, connected by a corridor. It...

Accurately measures the nociceptive threshold to infrared heat stimulus on the rat or mouse tail. Used for rapid screening of analgesic drugs by measuring reaction time to heat, even in anesthetized animals, crucial for repeated tests, thanks to the reflexive nature of the tail flick response.

Adjustable I.R. intensity, bright touch-screen display with intuitive controls. Comfortable...

Enables recording of spontaneous locomotor activity in rats and mice (individual or groups) using infrared (I.R.) beams. General activity can be an indicator of drug action, toxic substances, neurological damage, or daily rhythms in activity.

Tracks horizontal and vertical activity (rearing). Easily integrated with video-tracking system to measure XY position. Easy touch-buttons,...

Designed for inducing convulsions in research mice and rats for epilepsy studies and many more e.g., neurochemical and neuropharmacological research such as evaluating the depressant or stimulating action of drugs on the CNS.

Reproducible results. Parameters have been selected as the most suitable range for mice or rats. Flexibility to extend your experiments by adding other...

Measures the force on a rat or mouse paw according to the Randall-Selitto paw-pressure test, it enables rapid and precise screening of analgesic drugs for anti-nociceptive studies, in healthy or inflamed limbs. The device applies a steady increasing force, starting and stopping using the foot pedal. No calibration required. Digital model with force sensors and electronic unit is also...

The Grip Strength Meter determines the maximum force displayed by an animal in the forelimb, hind-limb or all four limbs, thanks to the full set of accessories included in the Ugo Basile Grip Strength Meter package.

The technique exploits the instinctive resistance of rodents to backward movements and their consequence tendency to grasp (grip) against the pull-back...

Compact, direct current (DC) Lesion Maker for localized electrolytic lesions in the brain.

Isolated, regulated DC output for electrical safety. Two operating modes: Continuous and Timed.

For stereotaxic surgery using rats or other small animals. Can be used to locate targets for implantation of devices, stimulation or injections.

Smooth, consistent movements with rapid positioning. Time-proven 'U'-Frame design provides stability and adaptability. Integrated warming base can be activated for better surgical outcomes.

The KDS Legato series is a range of advanced, precision syringe pumps. For applications requiring high metering precision at low, pulse-free flow rates.

Intuitive touch screen allows user to easily define complex injection protocols. Display presents real time data.

Provides precise information on the optimum day for mating during estrous cycle in the rats.

A powerful tool for improving reproduction efficiency. Simple, quick operation. Automatically calibrated when turned on. Designed for rats. A probe is available for mice.

Provides simple, reliable and precise calibration for Ugo Basile Plantar Test & Tail Flick and other infrared (I.R.) analgesia meters.

Running wheels provide a convenient method for measuring rodent spontaneous motor activity over long periods of time. Used for research on circadian rhythms, motor function, aging, energy balance, recovering and pain related exercise.

Robust mouse and rat models measure rodent activity across time. Models available with an LCD counter and can also be connected to a Windows PC. Data...

Studies natural curiosity and exploration behavior of rodents when confronted with a new environment (head-plunging, or nose-poking stereotype) according to the method devised by Boissier-Simon. For testing effects of psychotropic drugs on exploratory behavior.

The Boards are available with opaque or transparent walls for use with video tracking software. Mouse or rat versions.

Untainted, reliable samples enabled by a unique funnel and cone design that effectively separates rodent feces and urine into tubes outside the cage.

Collection tubes are easy to remove and the process will not disturb the animals.

Used to measure the paw withdrawal reflex when the mouse or rat paw is unexpectedly touched. For evaluating mechanical allodynia and cutaneous sensation levels. Popular non-invasive technique.

Set of 20 monofilaments based on the Semmes Weinstein monofilament set. An ascending series of increasingly stiff filaments (from 0.008 to 300 grams). Features retractable head to protect the...

The hot cold plate test has been the gold standard test for thermal pain tests in rodents for decades. Through the years the devices have been improving and the techniques have become more sophisticated, adding to constant temperature methods also other ones.

The Ugo Basile Hot/Cold plate test includes all the latest technologies necessary to run constant temperature, linear ramping...

Set-shifting task has proven to be an effective preclinical tool for drug testing and genetic screening, with direct translational valence in healthy humans and patients with schizophrenia.

The Ugo Basile Operon automatizes the Intra-/Extra-dimensional (ID/ED) attentional set-shifting battery of tests offering visual, olfactory and tactile stimulations, all controlled by software and...

The Ugo Basile Fear Conditioning system is composed of:

• Isolation cubicle, including all electronics, fan, IR/VIS lights, camera (up to 16 cubicles can be connected to 1 PC)
• The animal cage is available in different dimensions for rats and mice, plus the observational learning version to allow two animals to see each other. The standard...

An essential instrument to measure current on Ugo Basile devices using electric shock grid, such the Fear Conditioning System, Active an Passive avoidance system.

Give the research the ability to measure the electric shock current not measurable by a common volt-meter. To ensure that the same current is delivered on multiple electric shock grids, while performing multiple test in...

Pre-pulse inhibition of the Startle reflex (PPI) is a phenomenon in which a weak stimulus (sound or light, or air-puff) suppress the startle response to a subsequent stronger startle stimulus (of the same kind).

The interest in this technique is mainly due to the fact that impairment in PPI is normally linked to a dysfunction in the sensorimotor mechanism, which has been shown in...

A set up for testing active avoidance (also called automatic reflex conditioner or shuttle box), i.e. learning to predict the occurrence of an aversive event, based on the presentation of a specific stimulus. Enables performance of a wide range of avoidance experiments using a flexible schedule. Precise detection of avoiding aversive event. Manage up to 4 cages with one controller.