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Animal
Mouse, Rat

Thermal Place Preference for Mice and Rats

Product Code:35250/35260

Identifies temperature sensitivity and nociceptive pain thresholds. For pathophysiological exploration of animal pain models and pharmacological assessment of analgesic drugs. Often called the Two-Temperature Choice Test.

Easy touch screen controls for setting up and monitoring tests. Fast data portability. Fixed or ramp temperatures for dynamic experiments.

Model
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This product warranty can be extended up to 24 Additional Months.
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Background

  • Both heat and cold evoke thermosensation may elicit feelings of pain. Thermosensation is an essential sensory function which involves a variety of transducer molecules. 
  • The TPP (or 2-choice temperature test) is a thermal sensitivity assessment tool designed to emphasize integrated learned responses to thermal stimuli.
  • Escape behavior (latency) in unrestrained animals to innocuous and noxious heating or cooling of the floor can be monitored.
  • Unlike the traditional cold/hot plate test, this test is operator-independent. Rather than measuring the reaction time of an animal exposed to a certain temperature or ramp, the nociceptive response is provided by the animal as it chooses to move to its preferred position (comfort zone).

Dynamic experiments, easy control

  • Easy touch-screen controls to set and visually monitor the test.
  • An unrestrained animal (mouse or rats) can move freely between 2 circular compartments set at different temperatures. Temperature precision is 0.1°C.
  • Fixed or ramping temperature for dynamic experiments
  • Choose to make visual observations of animal response or use manual scoring software (ANY-maze Take Note).
  • Detailed information on animal behaviour can be recorded automatically using ANY-maze software including time spent in each temperature zone, animal activity, zone trespassing, distance run by the animal (total or by zone). Other video tracking software can also be used.
  • Data portability via the included USB Memory-Key
  • The Ugo Basile TPP consists of: 
    • A Hot/Cold Plate 
    • An additional Hot Plate
    • A set including special tubes, and a corridor for either mouse or rat to interconnect the two plates.
  • Can be used as an independent Hot/Cold plate and Auxiliary Hot Plate.

 

Features

Benefits

Two-environment temperature test  

Easily monitor thermal place preference and nociceptive thresholds

Unrestrained animals

less stress for the animal, less user errors, integrated learned responses to thermal painful and non-painful stimuli

Based on validated standard Ugo Basile devices

Can be used as independent Hot/Cold Plate Device and Auxiliary Hot Plate

Optional Videotracking System for automatic scoring and behavioral tracking

Bias-free reproducible data

Versatile device

Allows flexibility of tests and methods

 

General

Commands

Hot/Cold Plate: 4”3 touch-screen (resistive), Hot Plate: Themoregulator panel

Read-out

On the touch-screen

Power Requirement

Universal input 85-264 VAC, 50-60Hz, 200W max.

Sound Level

Max 60 dB (A)

Operating Temperature

18° to 25°C

 

Operation

Temperature

Hot/Cold Plate: adjustable in the range -5.0 to 65.0°C, with 0.1°C increments

Hot Plate: from room temperature to 65°C

Precision

+/- 0.1°C

Mode

Hot plate, cold plate, ramp (increasing or decreasing)

Counting Start

By START button or pedal switch

Counting Stop

By pedal switch

Latency Time Counter

Up to 999.9 seconds, in 0.1 steps

Data Acquisition

Via X-PAD software, provided

Data Portability

By USB flash drive, provided

TTL Output

For temperature and counter status

 

Physical

Total Weight

14Kg

Shipping Weight

20Kg approx.

Dimensions

50(w)x37(d)x47(h)cm – including restrainer

Packing Dimensions

68x34x28cm (two boxes)

 

Warranty

Warranty 35250 / 35260 are covered by a 12-month warranty + 12 after product registration
Ub-Care Additional UB-Care can be added for other 12 or 24 months

 

Both heat and cold evoke thermosensation, which, if of sufficient intensity, may elicit feelings of pain. Thermosensation is an essential sensory function that is subserved by a variety of transducer molecules.

Well-established methods are available to measure thermal and mechanical sensitivity in awake behaving rodents, however, they require experimenter manipulations and tend to emphasize reflexive behaviors.

The TPP (or 2-choice temperature test), is a thermal sensitivity assessment tool designed to emphasize integrated learned responses to thermal painful and non-painful stimuli that are applied dynamically to a surface on which the animal is standing. It documents escape behaviour in awake, unrestrained animals to innocuous and noxious heating of the floor where the animal is located. Animals learn to minimize pain by escaping to the opposite non-heated side; escape latency can be recorded automatically.

(from 2005 Baliki et al, Molecular Pain 2005, 1:18 doi:10.1186/1744-8069-1-18)

35250 Thermal Place Preference Test, for Mice and small Rats

35250

Thermal Place Preference Test, for Mice and small Rats, standard package, complete. The Package includes a complete Hot/Cold Plate, a complete Auxiliary Hot Plate, and a corridor/TPP tube set for Mice 35250-003

35150

Hot/Cold Plate Test, complete

35150-002

Auxiliary Hot Plate, complete

35250-003

Set of Special Tubes and Catwalk for Mouse, for Thermal Preference set-up 35250, opening 45x95(h)mm

 

35260 Thermal Place Preference Test, for Rats

35150

Hot/Cold Plate Test, complete

35150-002

Auxiliary Hot Plate, complete

35260-002

Set of Special Tubes and Catwalk for Rat, for Thermal Preference set-up 35260, opening 87x110(h)mm

 

Optional

60000-TN

Software ANYmaze for manual scoring

60000

ANYmaze videotracking system

47400-040

USB camera

 

Aziz Moqrich et alia: “Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin” Science 04 Mar 2005: Vol. 307, Issue 5714, pp. 1468-1472 https://science.sciencemag.org/content/307/5714/1468

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