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Animal
Mouse

Hot/Cold Plate - Screening of Thermal Hyperalgesia/Allodynia

Product Code:35150

Screens thermal hyperalgesia and allodynia, conditions often observed in patients with neuropathic pain or inflammation. Also used for testing analgesic and anti-inflammatory drugs.

Fixed or increasing temperature (RAMP) modes for dynamic experiments. Reaches user-defined temperatures within minutes. Touch screen or X-PAD software for setting up and monitoring tests, including complex temperature ramps.

Model
This product warranty can be extended up to 24 Additional Months.
Discover more HERE!

Background

  • Classic thermal pain test of animal's sensitivity to pain caused by exposure to hot or cold temperatures, causing nociceptive responses (hind paw licking, flinch or jump).
  • Used for precise, rapid screening tests for analgesic drugs (such as opioids), according to the N.B. Eddy and D. Leinbach hot plate test.
  • Useful to study cold receptors and thermal allodynia and hypersensitivity, a phenomenon often observed among persons with chronic pain.

Wide temperature range, fast and reliable

  • Wide operating temperature range suited to animal use from -5°C to 65°C. Adjustment steps of 0.1°C with a precision of 0.5°C.
  • Modes of operation for dynamic experiments:
    • Constant temperature.
    • Increasing/decreasing temperature (RAMP)
    • Exponential temperature (RAMP EXP)
    • Complex ramps (configured using the X-pad software)
  • Quickly reaches set temperatures. Reliably maintains temperatures.
  • Touch-screen to set and monitor the test.
  • Clear acrylic wall for easy observation (standard and custom height available).
  • Transfer data with the USB memory key
  • Lid reduces humidity condensation on the plate at low temperatures.
  • User friendly X-PAD software for setting up the experiment and managing the results.
  • Optional “auxiliary” Hot Plate 35150-002 is useful in the training and acclimation phase and for high-throughput tests.

  • OPERATING TEMPERATURE: -5.0°C to 65.0°C in steps of 0.1°C, with a precision of 0.5°C
  • OPERATING MODES: fixed or ramping temperature, for dynamic experiments
  • X-PAD SOFTWARE: brand new, user friendly software included as standard, to set up the experiment and manage the results
  • CONTROLS: 4”3 touch-screen to set and monitor the test
  • DATA PORTABILITY: via the USB Memory-Key, included
  • TERMOMETER: Embedded in the instrument you will find a termometer which tells the environmental temperatur

General

Commands

4,3 inches touch-screen (Resistive)

Read-out

4,3 inches touch-screen (Resistive), PC

Power Requirement

Universal input 100-240 VAC, 50-60Hz, 200W max

Sound Level

70 dB

Operating Temperature

18°C to 25°C

Detection By pedal switch

 

Operation

Temperature

-5.0 to 65.0°C

Precision

+/- 0.1°C

Mode

Hot plate, Cold plate, Ramp (increasing or decreasing), Silent

Detection By Pedal Switch

Start

By START button or pedal switch

Stop

By STOP button or pedal switch

Latency Time Counter

Up to 999.9 seconds, in 0.1 steps

Data Acquisition

Via X-PAD software, provided

Data Portability

By USB flash drive, provided

Data Input Personalized protocol
Data Output Results in .csv

TTL Output

Temperature, Start, Stop

 

Physical

Total Weight

8Kg

Shipping Weight

12Kg

Dimensions

25(w)x37(d)x47(h)cm – including restrainer

Packing Dimensions

68x34x28cm

 

Warranty

Warranty 35150 is covered by a 12-month warranty + 12 after product registration 
UB-Care  Additional UB-Care can be added for other 12 or 24 months

 

Optional
An “auxiliary” conventional Hot Plate 35150-002 is available as optional; this self-standing unit may be used for the habituation phase before the test, thus reducing the use of the main unit to the test proper.

The hot plate tests the pain response in animals, used in basic pain research and in testing the effectiveness of analgesics by observing the reaction to pain caused by heat.

The method, devised by N.B. Eddy and D. Leimbach in 1953 (see paragraph 8.1-Method Papers) evaluates the reaction time of mice dropped on a heated surface and thus confronted with a heat stimulus applied to the plantar surface.

Eddy and Leimbach used a behavioral model of nociception where behavior such as jumping and hind paw-licking are elicited following a noxious thermal stimulus. Licking is a rapid response to painful thermal stimuli that is a direct indicator of nociceptive threshold. Jumping represents a more elaborated response, with a latency, and encompasses an emotional component of escaping.

When a central analgesic agent is administered to the animals, reaction time is markedly increased.

The new Hot/Cold Plate 35100 has been designed to study more recently published cold receptor systems of neurons, which are not activated by cold but rather by chemicals, as well as the traditional cold receptors. These neurons are present in the CNS as well as PNS, but they are different from the neurons which sense pain.

35150 Hot/Cold Plate, complete with standard accessories

35150-001 Cabinet (controller with touch-screen and Plate assembly)
35100-286 Cylindrical Animal Restrainer, for Mice and Rats, 25cm height
35150-320 Restrainer Lid
37215-303 Pedal Switch
E-AU 101 USB pen drive, including instruction manual and X-PAD  dedicated software package
E-WP008 Main Power Cord

Options

35150-002 Additional Hot Plate
35160 Combo package 35150 and 35150-002 
35250-003 Set of Tubes/Catwalk for 35250
35260-002 Set of Tubes/Catwalk for 35260
35250 / 35260 Thermal Place Preference
  • N.B. Eddy & D. Lembach: “Synthesis, Anti-Inflammatory and Analgesic Activity of Pyrido [2, 1-b] Quinazoline Derivatives” J Pharma Exp 953: 703-385, 1953
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