UB Care
Additional Warranty can be added to this product for other 12 or 24 months.
Discover more about our warranty policy.

The hot cold plate test has been the gold standard test for thermal pain tests in rodents for decades. Through the years the devices have been improving and the techniques have become more sophisticated, adding to constant temperature methods also other ones.
The Ugo Basile Hot/Cold plate test includes all the latest technologies necessary to run constant temperature, linear ramping temperature (toward hot or toward cold) and complex temperature ramps thanks to the included X-Pad software.
Moreover, the new model includes a keypad (cabled or optional Bluetooth) to score pain endpoints or stereotyped behaviors.
Temperature range goes from -5° to 65°C and animal holders of different heights are available.
The Ugo Basile Hot/Cold Plate system comes complete with:
Additional features include:
Feature |
Benefit |
---|---|
Fixed, ramping and complex ramp temperature modes |
Flexibility for performing many types of pain experiments from allodynia to hyperalgesia |
Keypad and pedal for scoring pain animal responses and stereotyped behaviors |
Possibility to use the preset 10 keys or modify them (licking, scratching, jumping, grooming, vocalization, rearing, immobility, climbing, shivering, twitching) and save the results in the electronic unit |
Broad range of temperatures (-5° to -65°) |
Allows to perform any sort of thermal sensitivity experiment, including severe cold allodynia |
Ambient temperature sensor is placed outside of the device |
Improved system and thermal accuracy |
Silent mode of operation or the air dissipation system |
Less disturbance to the animal |
Control unit and USB key saving |
No need to connect a PC |
Automatic conversion of data into CSV files for the USB stick |
Possibility to open files in Excel |
PC software |
Possibility to populate your vivarium of animals and to build complex temperature ramps |
General | |
---|---|
Commands |
4,3 inches touch-screen (Resistive) |
Read-out |
4,3 inches touch-screen (Resistive), PC |
Power Requirement |
Universal input 100-240 VAC, 50-60Hz, 200W MAX |
Sound Level |
70 dB |
Operating Temperature |
18°C to 25°C |
Detection |
By pedal switch and via numeric key pad |
Operation | |
Plate temperature range | -5.0°C to +65°C (in 0.1°C steps) |
Accuracy | +/- 0.2°C |
Mode | Fixed temperature, Ramp (increasing or decreasing), Silent, Fast Ramp, Custom Ramp |
Start | By START button or pedal switch |
Stop | By STOP button or pedal switch |
Experiment duration | Max 999.9 seconds |
Data Acquisition | Via X-PAD software (included) |
Data Portability | By USB flash drive (included) |
Data Input | Personalized protocol |
Data Output | Results table in .csv |
TTL Output | Temperature, Start, Stop |
The advantages of the hot/cold plate are the broad temperature range and hence the possibility to assess both hot and cold allodynia and hyperalgesia. In the last year the tendency has been to use the increasing/decreasing mode more and more frequently to differentiate nociceptor sub-types and hence detect both hyperalgesia and allodynia.
A typical application is during inflammatory pain, as well as in neuropathic pain and to test compounds with anti-nociceptive effects, for example after chronic constriction injury (CCI) or other methods.
The test is mainly used in rodents, but we have seen use in drosophila as well (see literature below, Massingham et al. 2021).
The new model which incorporates now, at no extra cost, the keypad allows for scoring of several behaviors, which before was possible only by videotaping and reviewing the videos, while now it can all be done on-line, during the test.
35300 Hot/Cold Plate includes: | |
---|---|
35300-001 |
Hot/Cold Plate, with USB output, USB flash drive (MY22 model), without animal enclosure |
35300-006 |
Hot/Cold Plate USB wired numeric key-pad (only use with 35300)
|
35100-286 |
Mouse/Rat Restrainer for Hot/Cold Plate, height 25cm |
37215-303 |
Pedal Switch, complete with cable and connector |
E-AU 101 |
Memory Key, including the user manual and X-pad software |
Power cable according to your Country | |
Options | |
35150-002 | Additional Hot Plate |
35100-285 | Animal Restrainer for Hot Plate, 31 cm height |
35100-287 | Mouse/Rat Restrainer for Hot/Cold Plate, customized height, please specify |
35300-005 | Hot/Cold Plate wireless USB key-Pad (only use with 35300) |
35250-003 | Set of Special Tubes and Catwalk for Mouse, for Thermal Preference set-up |
35260-002 | Set of Special Tubes and Catwalk for Rat, for Thermal Preference set-up |
35300-UBC12 | UB Care 12 - Additional hardware warranty extension 12 months for Hot/Cold Plate |
35300-UBC24 | UB Care 24 - Additional hardware warranty extension 24 months for Hot/Cold Plate |
Eva Mercado et al., 2022, SGK1.1 isoform is involved in nociceptive modulation, offering a protective effect against noxious cold stimulus in a sexually dimorphic manner, Elsevier
Damien C. Boorman and Kevin A. Keay, 2021, M*rphine-Conditioned Placebo Analgesia in Female and Male Rats with Chronic Neuropathic Pain: c-Fos Expression in the Rostral Ventromedial Medulla, Elsevier
S. Al-Mazidi et al., 2017, Blocking of cytokines signalling attenuates evoked and spontaneous neuropathic pain behaviours in the pa*lita*el rat model of chemotherapy-induced neuropathy, European Journal of Pain
Petersen et al., 2019, Distinct functions of soluble guanylyl cyclase isoforms NO-GC1 and NO-GC2 in inflammatory and neuropathic pain processing, PAIN
Yasunori Haranishi, Koji Hara, Tadanori TeradaInhibitory, 2021, Inhibitory effect of intrathecally administered AM404, an endocannabin*id reuptake inhibitor, on neuropathic pain in a rat chronic constriction injury model, Pharmacological Reports
Koji Hara et al., 2020, Intrathecally administered pe*ampa*el alleviates neuropathic and inflammatory pain in rats, Elsevier
Urru Matteo, 2020, Dexpramipex*le blocks Nav1.8 sodium channels and provides analgesia in multiple nociceptive and neuropathic pain models, PAIN
Josephine N. Massingham, 2021, Evaluating Baseline and Sensitised Heat Nociception in Adult Drosophila, Bio Protocol
Moritz Moller et al., 2022, The Role of AlphαSynuclein in Mouse Models of Acute, Inflammatory and Neuropathic Pain, Cells
Additional Warranty can be added to this product for other 12 or 24 months.
Discover more about our warranty policy.