Quote list0
Your product list is empty!


Startle/PPI Test Multiple-cage Set-Up for Mice

Product Code:48163/48263/48463

Automatic detection of the startle reflex (pre-pulse inhibition PPI) in mice. Particularly for research into psychiatric disorders, drug use and more.

Customizable, complete set up, ready to go. Includes controller, touch screen, Startle Link-Box, Isolation Cubicles, Stimulating/Recording Platform.

Model
Choose a model to get a quote...
This product warranty can be extended up to 24 Additional Months.
Discover more HERE!

Background

  • The startle response (PPI) is a largely unconscious defensive response to sudden or threatening stimuli, such as sudden noise or sharp movement, and is associated with a negative effect. Startle stimuli are usually acoustic. Tactile stimuli and light-based stimuli are also used.
  • Deficits of PPI have been linked to abnormalities of sensorimotor gating, often in patients with psychiatric disorders such as Schizophrenia and Alzheimer’s Disease, or under the influence of drugs, surgical manipulations, mutations or elderly.
  • Animal models are widely used to test hypotheses linking genetic components of various diseases with sensorimotor gating.

Complete set up, ready to go

  • Automatic detection of Startle Reflex in mice
  • Complete set up, ready to start your tests. Customizable to suit your needs. A typical system combines the following elements:
    • Dedicated Software
    • Startle Link-Box (collects and conveys signals to Controller)
    • Up to 4 Isolation Cubicles that includes an infrared (I.R.) light, a loudspeaker and a noiseless fan, all conveniently positioned inside the sound attenuating box
    • Stimulating/Recording (S/R) Platform (includes the light, speaker and detection system)
    • 2 Animal Boxes – large and small (no holder)
  • Flexible testing, easy to set up. Simply define trial number, sound and light stimulus and timing of experimental sequences (all fully randomizable):
    • Pulse
    • Pre-pulse
    • Inter-Pulse Interval
    • Inter-Stimulus Interval
  • Add multiple cages using expansion-cubicle/s featuring slave electronics.
  • Connects to the flexible, cost effective beehive cage-manager system. Use one touch screen controller to control and manage all of your Ugo Basile cages. Ask for details!

Features

Benefits

Maximum Flexibility, full event randomization

Configure your own Experimental Schedules directly on your PC

Remote Control feature

Makes remote service and software upgrades extremely simple!

Great Versatility

The same controller can manage different conditioning tests. Ask for details!

 

General

Power Requirements

Universal input 100-240 VAC, 50-60Hz, 60W

Sound Level + Whitenoise

< 60 dB

Operating environment

10°C to 40°C; 5% to 95% RH (non-condensing)

Operation

Sound Range

From 65 dB to 120 dB

Pulse/pre pulse sound range (at 3KHz) From 65 dB to 120 dB
Sound Frequency Range From 100 Hz to 18 KHz
IR Light

0-100% (Environment)

Flash Light

0-100% (20K Lux) S/R Platform)

Data Export

.csv, .xlsx format

Number of cages Up to 4

Physical

Dimensions

25(d)x33(w)x5.5(h)cm (40500-001)

Internal Dimensions

Small Mouse: ID 84x34x39(h)mm

Large Mouse: ID 84x39x44(h)mm

Weight

2.7Kg

Shipping Weight

Mouse Single-Cage Set-Up: 40Kg

Packing Dimensions

82x71x57cm (wooden crate) for a Mouse Single-Cage Set-up

Warranty

Warranty Startle PPI is covered by a 12-month warranty + 12 after product registration
UB-Care Additional UB-Care can be added for other 12 or 24 months

 

In animals, including humans, the startle response is a largely unconscious defensive response to sudden or threatening stimuli, such as sudden noise or sharp movement, and is associated with negative effect. Usually the onset of the startle response is a startle reflex reaction, a brainstem reflectory reaction (reflex) that serves to protect vulnerable parts, such as the back of the neck (whole-body startle) and the eyes (eyeblink) and facilitates escape from sudden stimuli.
Prepulse Inhibition (PPI) is a neurological phenomenon in which a weaker prestimulus (prepulse) inhibits the reaction of an organism to a subsequent strong startling stimulus (pulse). The stimuli are usually acoustic, but tactile stimuli (e.g. via air puffs on the skin) and light stimuli are also used.
The reduction of the amplitude of startle reflects the ability of the nervous system to temporarily adapt to a strong sensory stimulus when a preceding weaker signal is given to warn the organism.
Deficits of prepulse inhibition, manifesting in the inability to filter out the unnecessary information, have been linked to abnormalities of sensorimotor gating, noted in patients suffering from illnesses like Schizophrenia and Alzheimer’s Disease, or under the influence of drugs, surgical manipulations, or mutations. Animal models are widely used to test hypotheses linking genetic components of various diseases with sensorimotor gating.

48153 Startle/PPI System for Mice, single cage system

40500-001

Controller with Touch Screen and 8-pole Scrambling Shocker

48005

Stimulating/Recording Platform for Mouse

48000-320

Small Mouse Box

48000-322

Large Mouse Box

48000-100

Startle link-box

46000-590

Isolation Cubicle, sound attenuation box with IR Light, loudspeaker, noiseless fan

52010-323

USB pen-drive, including

48253 STARTLE/PPI SYSTEM FOR MICE, two-cage system

40500-001

Controller with Touch Screen and 8-pole Scrambling Shocker

48005

Stimulating/Recording Platform for Mouse

48000-320

Small Mouse Box

48000-322

Large Mouse Box

48000-100

Startle link-box

46000-590

Isolation Cubicle, sound attenuation box with IR Light, loudspeaker, noiseless fan

52010-323

USB pen-drive, including

48453 STARTLE/PPI SYSTEM FOR MICE, four-cage system

40500-001

Controller with Touch Screen and 8-pole Scrambling Shocker

48005

Stimulating/Recording Platform for Mouse

48000-320

Small Mouse Box

48000-322

Large Mouse Box

48000-100

Startle link-box

46000-590

Isolation Cubicle, sound attenuation box with IR Light, loudspeaker, noiseless fan

52010-323

USB pen-drive

 

M. Koch: “The Neurobiology of Startle” Prog Neuro­biol. 59(2):107-28, 1999

D. Braff et alia: “Human Studies of Prepulse Inhibition of Startle: Normal Subjects, Patient Groups, and Phar­macological Studies” Psychopharmacology 156(2): 234-258., 2001

H.S. Hoffman et al.: “Startle Reaction: Modification By Background Acoustic Stimulation” Science 141: 928-30, 1963

R.R. Marsh et alia: “The Role of Small Changes in the Acoustic Environment in Modifying the Startle Reflex” J Exp Psychol Anim Behav Process, 1(3): 1975

Back to: Behaviour, Conditioning, Reward