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Treadmill - Interchangeable Lane Assembly for Mice and Rats

Product Code:47300/47350

Measures endurance, distance and speed. For studying behavioral, physiological, biochemical, and molecular responses to both acute exercise stress and chronic exercise training.

Original product by Ugo Basile is adaptable for use by rats or mice. Easy set up and control using touch screen. Automatic measurement of endurance, distance and speed. Shock grid for aversive stimulus (if required) is included on all models.

Adjustable inclination and speed. Selectable acceleration modes.

Model
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This product warranty can be extended up to 24 Additional Months.
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Background

  • “Exercise is a multifactorial activity that affects virtually every organ and tissue in the body. Not only does exercise contribute many health benefits, but lack of exercise is implicated in many chronic health problems. As evidence continues to accumulate concerning the impressive range of health benefits that exercise confers, biomedical researchers have increasingly become interested in conducting systematic studies of exercise to further define those benefits” (from Resource Book for the Design of Animal Exercise Protocols, APS, Feb 2006).

Product Features

  • Adaptable for use with rats or mice with simple replacement of the lane assembly. Combination Rat/Mouse package available or easy upgrade to dual use at a later stage.
  • Incorporates a shock grid at the back of the treadmill to deliver an adjustable mild electric shock, when an aversive stimulus is required. Shock can be pre-set from 0 to 2mA (in 0.1mA steps), with a frequency of 1, 2 or 3 Hz.
  • Test settings & monitoring are managed on the 4” touch-screen in the attached control unit.
  • The running-lane assembly can be manually tilted from -25° to +25°, in steps of 5°.
  • Endurance, distance (absolute and relative) and speed are automatically measured and recorded.
  • Speed can be selected from 3 to 100m/min, in steps of 1m/min, in constant, accelerating or custom ramp modes.
  • A special lane-assembly for tethered mice is also available as an alternative to the standard model.
  • X-PAD software to set up the experiment and manage the results is included.
FeatureBenefits

One device for both rats and mice

MODES: constant, accelerating, custom ramps

SLOPE: positive (uphill) or negative (downhill), from -25 to +25°, in 5° steps

SPEED: from 3 to 100m/min, in steps of 1m/min amps

SHOCK: from 0 to 2mA (in 0.1mA steps), included

DETECTION: via incorporated electronic circuit automati­cally detects speed & absolute and relative distances

CONTROLS: 4,3 inches touch-screen to set and monitor the test

X-PAD SOFTWARE: brand new, user-friendly version, to set the experiment and manage the results

General

Commands

4,3 inches touch-screen (Resistive)

Read-out

Touch-screen and PC

Power Requirement

Universal input 100-240 VAC, 50-60Hz, 150W max.

Sound Level

80 dB ca. at maximum speed

Operating Temperature

10° to 40° C

Operation

Speed

Adjustable in the range 3 to 100m/min, in steps of 1m/min

Mode

Constant, Ramp (accelerating), Multi-step personalized ramp

Slope

Manual tilting, positive (uphill) or negative (downhill) from -25° to +25°, in steps of 5°

Shock

From 0 to 2mA (in 0.1mA steps), 1, 2 or 3Hz

Start/Stop

From the touch-screen

Detection

When touching the shocker

Results

Time Elapsed, Speed, Distance (absolute and relative), Shocks number, Events.

Data Acquisition

Via dedicated X-PAD software or .cvs file for PC.

Data Portability

By USB flash drive

TTL Output

Shock status, running status and speed

Data Out

exported to .cvs

Data In

exported to .cvs, protocol, ramp

Physical

Total Weight 27Kg
Shipping Weight 40Kg
Dimensions 56(w)x67(d)x35(h)cm
Packing Dimensions 82x71x57cm
Warranty
Warranty Treadmill is covered by a 12-month warranty + 12 after product registration
UB-Care Additional UB-Care can be added for other 12 or 24 months 

“Exercise is a multifactorial activity that affects virtually every organ and tissue in the body. Not only does exercise contribute many health benefits, but lack of exercise is im-plicated in many chronic health problems.
As evidence continues to accumulate concerning the impressive range of health benefits that exercise confers, biomedical researchers have increasingly become interested in conducting systematic studies of exercise to further define those benefits”.
Fatigue is a common and frequently poorly-understood symptom in many diseases and disorders. New preclinical assays of fatigue may help to improve current understanding of fatigue-like behavior in rodents and many other exercise paradigms and study future treatment of fatigue.
Treadmills are rolling belts (tapis-roulants) with presettable speed and adjustable uphill and downhill inclination (slope), enabling forced exercise training and accurate testing of fatigue in lab animals.
“Treadmill running has been used extensively over the past decades to study behavioral, physiological, biochemical, and, more recently, molecular responses to both acute exer-cise stress and chronic exercise training. Although investigators have used a wide variety of species (…) for treadmill running studies, they have used rodents in most of these studies.
Treadmill running has the distinct advantage over other forms of exercise, including spontaneous wheel running and swimming, that the total amount of external work done by the rat can be easily calculated.
Treadmill running may be construed as a form of forced exercise in which the animal does not have a choice of participating in the activity. Because of this, noxious stimuli (e.g., electric shock and bursts of high-pressure air) may be needed to motivate the animals to exercise”
(from Resource Book for the Design of Animal Exercise Protocols, APS, Feb 2006)

 

47302 Rat Treadmill, complete with following accessories

47300-001

Tapis-Roulant with touch-screen controller and shocker

47300-002

3-Lane partition assembly for Rats, each lane 45x11x15(h)cm, with transparent cover

47300-005 Shock and detection controller

E-AU 101

USB pen drive, including instruction Manual and X-PAD Software Package

47303 Mouse Treadmill, complete with following accessories

47300-001

Tapis-Roulant with touch-screen controller and shocker

47300-003

6-Lane partition assembly for Mice, each lane 45x5.5x7(h)cm, with transparent cover

47300-005 Shock and detection controller

E-AU 101

USB pen drive, including instruction Manual X-PAD Software Package

47300 Combo Package: Mouse & Rat Treadmill

47300-001

Tapis-Roulant with touch-screen controller and shocker

47300-002 3-Lane partition assembly for Rats, each lane 45x11x15(h)cm, with transparent cover

47300-003

6-Lane partition assembly for Mice, each lane 45x5.5x7(h)cm, with transparent cover

47300-005 Shock and detection controller

E-AU 101

USB pen drive, including instruction Manual X-PAD Software Package

47350 Combo Package: Mouse & Rat Treadmill plus Air Puff Detection

47300-001

Tapis-Roulant with touch-screen controller and shocker

47350-002

3-Lane partition assembly for Rats, each lane 45x11x15(h)cm, with transparent cover

47350-003 6-Lane partition assembly for Mice, each lane 45x5.5x7(h)cm, with transparent cover
47350-005 Treadmill AirPuff Option including shock grid

E-AU 101

USB pen drive, including instruction Manual and X-PAD Software Package

47352 Rat Treadmill plus Air Puff Detection

47300-001

Tapis-Roulant with touch-screen controller and shocker

47350-002

6-Lane partition assembly for Mice, each lane 45x5.5x7(h)cm, with transparent cover

47350-005 Treadmill AirPuff Option including shock grid

E-AU 101

USB pen drive, including instruction Manual X-PAD Software Package

47353 Mouse Treadmill plus Air Puff Detection

47300-001

Tapis-Roulant with touch-screen controller and shocker

47350-003

6-Lane partition assembly for Mice, each lane 45x5.5x7(h)cm, with transparent cover

47350-005 Treadmill AirPuff Option including shock grid

E-AU 101

USB pen drive, including instruction Manual X-PAD Software Package

Optional

47300-013

6-lane assembly (each lane 45x5.5, height 15cm, without lid, for te­thered mice)

 

American Physiological Society: “Resource Book for the Design of Animal Exercise Protocols” February 2006

O.J. Kemi et alia: “Intensity-Controlled Treadmill Running in Mice: Cardiacand Skeletal Muscle Hypertrophy” J. Appl. Physiol. 93: 1301-1309, 2002

X.Q. Wang & G.W. Wang: “Effects of Treadmill Exercise Intensity on Spatial Working Memory and Long-Term Memory in Rats” Life Sciences 149: 96-103, 2016

M. Shinozaki et alia: “Combined Treatment With Chondroitinase ABC and Treadmillrehabilitation for Chronic Severe Spinal Cord Injury in Adult Rats” Neuroscience Res 113: 37-47, 2016

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