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Animal
Mouse, Rat

ECT Unit (Electroconvulsive-Therapy) - threshold detection

Product Code:57800

Designed for inducing convulsions in research mice and rats for epilepsy studies and many more. e.g., neurochemical and neuropharmacological research such as evaluating the depressant or stimulating action of drugs on the CNS. For neurochemical and neuropharmacological research such as evaluating the depressant or stimulating action of drugs on the CNS.

Reproducible results. Parameters have been selected as the most suitable range for mice or rats. Flexibility to extend your experiments by adding other transducers.

Model
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Background

  • Particularly useful for neurochemical and neuropharmacological research such as;
    • General screening of potentially neurotropic substances
    • Evaluating the depressant or stimulating action of drugs on the CNS
    • Endocrinological investigations on the relationship between the nervous system and the hypophysis.

 Accurate and reproducible

  • A constant current stimulator ensures reproducible results and accurate determination of the EC threshold.
  • The impedance to the animal can be pre-measured and displayed. A warning is provided if the impedance is too great to deliver the desired current level, rather than the most suitable range for mice or rats.
  • The Electroconvulsive Device is supplied with auricular (ear lobe) electrodes that allow an operator to deliver shock to a number of animals in a short time.
  • Pinpoints variations in the threshold affected by drug action on cortex and sub-cortical regions.
  • Can be used with other electrodes allowing for virtually any procedure.
  • Analog output for connection to an oscilloscope or data acquisition system.
  • An optional Biphasic Unit box may be placed between the animal and the Electroconvulsive Device to invert every other pulse. Maximum frequency in this case becomes 100Hz.
  • Corneal electrodes are optional. Also custom designed electrodes are available on request.

 

Feature

Benefit

Optional analogue output    

Can be connected to oscilloscope

Any type of electrode can be used    

Allows for virtually any procedure

Feedback circuitry

Compensates for impedance variability due to animal-electrode contact  

 

General
Power Requirements 115/230V - 50/60Hz – 100W
Constant Current Controlled by a feedback network
Current Range 0-99mA in 1mA steps ±2%
Pulse H.V. transformer
Pulse Width 0.1ms to 0.9ms in 0.1ms steps ±1%
Pulse Rise&Fall Time 20μs
Pulse Voltage 3KV Max
Frequency (pulses/s) 1-299 in 1 pulse/s steps ±1%
Shock Duration 0.1s to 9.9s in 0.1s steps ±1%
Output Resistance  Min 0Ohm - Max. 30KOhm (at max. current)
KOhm Display 0-199 KOhm - 1KOhm resolution
Warranty
Warranty ECT is covered by a 12-month warranty + 12 after product registration.
UB-Care Additional UB-Care can be added for other 12 or 24 months

The ECT Apparatus is specially designed for neurochemical and neuropharmacological research. It is particularly useful for:

  • general screening of potentially neurotropic substances
  • evaluating the depressant or stimulating action of drugs on the CNS
  • endocrinological investigations on the relationship between the nervous sys-tem and the hypophysis.

A constant current output is used which ensures reproducible results and accurate determination of the EC threshold while also pinpointing any variation in the threshold brought about by drugs having specific action on the cortex and subcortical regions.
The shock parameters have been selected after consulting the most recent literature, in order to determinate the range of requirements likely to be needed when operating with mice and rats.
6Hz model: The 6-Hz corneal stimulation model, which was introduced in early fifties, has been recently rediscovered to test alternative approaches for drug-resistant seizures. Accordingly the ketogenic diet, which is known to be a valid treatment for refractory seizures, was found to be effective in counteracting seizures induced by the 6-Hz corneal stimulation. When compared with other models based on electrical stimulation, the 6-Hz paradigm is characterized by the induction of minimally convulsive or non-convulsive seizures with automatized behaviors, defined as “psychomotor seizures”. Ugo Basile ECT Unit performs the 6Hz model conveniently.

57800 ECT Unit, complete with standard accessories

57800-001

Pulse Generator

57800-002

Set of Auricular Electrodes

57800-303 Foot Pedal

57800-320

Set of Felt Pads for Auricular Electrodes

E-AU 041

USB pen drive, including:

57800-302 Instruction Manual

Options

57800-003

Set of Corneal Electrodes

57800-002

Bipolar Inverter

57800-015

ECT Monitor, complete with connection cables

 

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