PAM Pressure Application Measurement (for joint pain)

Name: PAM Pressure Application Measurement (for joint pain)
Brand: Ugo Basile
SKU: 38500/38550

Product Code:38500/38550

Category: Pain and Inflammation

The P.A.M. (Pressure Application Measurement) device is an original tool designed for measuring mechanical pain threshold on joints. It was specifically designed and validated for Arthritis research and is therefore especially suited to assess joint hypersensitivity in rodent knees or ankles. Once saved, data can be browsed on the control unit and/or transferred to a PC in proprietary, Excel or text format, to be managed by most statistical analysis packages available on the market. It can also be used as a Paw Pressure Measurement system with the right adaptor (PN 38500-006).

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An extended warranty can be added for most Ugo Basile products. You can find this information in the ordering information section of each product.
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Detailed description +-

The PAM applies a quantifiable force for direct stimulation of the joint and for automatic readout of the response.
The operator is ensured high sensitivity by wearing the sensor directly on the thumb
The operator simply wears a special force sensor on his or her thumb and the peak amplifier measures the force which elicits the animal response (normally, limb withdrawal).
Each PAM device comes standard with two pre-calibrated force sensors, which have been specially designed to apply force to rat and mouse joints.
The device includes as standard both a control unit with two sensors of different sizes, and the NEW DCA software for signal monitoring, data transfer and analysis. Once saved, data can be browsed on the control unit and/or transferred to a PC in proprietary, Excel (.xls) or text (.txt) format, to be managed by most statistical analysis packages available on the market.
The PAM device can also be used to measure mechanical sensitivity in the mouse or rat paw, by using a specific Paw Pressure Transducer (optional).

Features & Benefits +-

Feature	Benefits
The force is applied directly to the joint	Direct measurent of evoked pain on the specific site
Pre-calibrated force transducers	No calibration needed
Specifically designed for arthritis research	The applicators are shaped for rodents knee and ankle
Paw pressure transducer as an optional	PAM can also be used as a hand-held Randall-Selitto device
Foot pedal included	Also manual scoring is possible for those cases when the automatic peak detector cannot be used

Specifications +-

Operation
Commands	Via soft buttons and pedal
Read-out	LCD Screen, via the DCA3 Software on the PC
Start	Automatic start at pressure adjustable threshold
Stop	Automatic at end of pressure, Automatic after a time limit (adjustable from 5 to 25 seconds), Manual by pedal
Force Ranges	0-500gf, 0-1500gf
Force Increasing Rate	Monitored via PAM Electronic Unit or via the DCA3 Software on the PC
Force Response	in 0.1gf steps
Latency Time	in 0.1s steps
Connection to PC	via USB cable (A to mini-B) and PAM Software (DCA3)
Power Requirement	Either battery operated, via USB cable connected to PC, included power supply (100-240 VAC, 50-60Hz)
Operating Temperature	10°C to 40°C; 5% to 95% RH (non-condensing)
Sound Level	Negligible

Physical
Total Weight	0.8Kg
Shipping Weight	2.7Kg approx.
Dimensions	12(w)x15(d)x4,5(h) cm
Packing Dimensions	46x38x27cm
Warranty
Warranty	PAM is covered by a 12-month warranty + 12 after product registration
UB-Care	Additional UB-Care can be added for other 12 or 24 months

Application +-

The PAM applies a quantifiable force for direct stimulation of the joint delivering an automatic readout of the animal response.

The PAM was initially designed for Rheumatoid Arthritis, but it can obviously be used for many applications which aim at the assessment of the joint nociceptive threshold or at the threshold also in other parts of the body in rodents or large animals (with a special adapter).

Since its introduction, more than 10 years ago, dozens of papers have been published on several type of inflammation models and nociception studies in general (see references below). These include the most classic arthritis, fibromyalgia, induced joint damage, induced musculoskeletal pain, and many others.

Ordering informations +-

38500 PAM Pressure Application Measurement
38500-001	Electronic Unit
38500-002	Large Joint Transducer (Rat)
38500-003	Small Joint Transducer (Mouse)
38500-303	Pedal Switch for 38500, 38450, 47200
52010-325	USB Cable
E-AU 059	Universal Power Supply
E-AU 101	USB pen-drive, including Instruction Manual and Software
Optional for 38500
38500-006	Paw Pressure Applicator
38550 PAM Pressure Application Measurement for large animals
38500-001	Electronic Unit
38500-010	Software
38500-016	PAM Paw Pressure Applicator, special high pressure model for large animals, complete with transducer and 3 probes (cone and filaments) of different shape/size
38500-303	Pedal Switch for 38500, 38450, 47200
38450-330	Spare filament with magnetic attachment
38550-320	Spare filament (short) for PAM 38550 with magnetic fixing system
38550-321	Spare Perspex pointed pusher for PAM 38550, with magnetic fixing system
52010-325	USB Cable
E-AU 059	Universal Power Supply
E-AU 101	USB pen-drive, including Instruction Manual and Software

Main References +-

H. Tamai, M. Yamanaka, W. Taniguchi, N. Nishio, D. Fukui, T. Nakatsuka, H. Yamada, 2023, “Transient receptor potential ankyrin 1 in the knee is involved in osteoarthritis pain”, Biochemistry and Biophysics Reports

L. Singh, A.Kaur, S. Garg, A. P. Singh, R. Bhatti, 2020, “Protective Effect of Esc*letin, Natural Coumarin in Mice Model of Fibromyalgia: Targeting Pro-Inflammatory Cytokines and MAO-A”, Neurochemical Research

A. Obeidat, S. Ishihara, R. Miller, A.-M. Malfait, 2020, “Effect of systemically delivered zoledronic acid on joint damage, nociceptive knee innervation and pain after destabilization of the medial meniscus in mice”, Osteoarthritis and Cartilage

A.Kaur, L. Singh, N. Singh, M. S. Bhatti, R. Bhatti, 2019, “Ameliorative effect of imperatorin in chemically induced fibromyalgia: Role of NMDA/NFkB mediated downstream signaling”, Biochemical Pharmacology

P. Di Giminiani, S. A. Edwards, E.M. Malcom, M.C. Leach, M. S. Herskin, D. A. Sandercock, 2017, “Characterization of short- and long-term mechanical sensitisation following surgical tail amputation in pigs”, Nature

J. Leuchtweis, A.-K. Imhof, F. Montechiaro, H.-G. Schaible and M.K. Boettger, 2010, “Validation of the digital pressure application measurement (PAM) device for detection of primary hyperalgesia in rat and mouse antigen-induced knee joint arthritis”, Methods and Findings in Experimental and Clinical Pharmacology

Resources & Downloads +-

Instruction Manual P.A.M. Leaflet

Video +-