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Mouse, Rat

PAM Pressure Application Measurement (for joint pain)

Product Code:38500/38550
The P.A.M. (Pressure Application Measurement) device is an original tool designed for measuring mechanical pain threshold on joints. It was specifically designed and validated for Arthritis research and is therefore especially suited to assess joint hypersensitivity in rodent knees or ankles. Once saved, data can be browsed on the control unit and/or transferred to a PC in proprietary, Excel or text format, to be managed by most statistical analysis packages available on the market. It can also be used as a Paw Pressure Measurement system with the right adaptor (PN 38500-006).
This product warranty can be extended up to 24 Additional Months.
Discover more HERE!

  • The PAM applies a quantifiable force for direct stimulation of the joint and for automatic readout of the response.
  • The operator is ensured high sensitivity by wearing the sensor directly on the thumb
  • The operator simply wears a special force sensor on his or her thumb and the peak amplifier measures the force which elicits the animal response (normally, limb withdrawal).
  • Each PAM device comes standard with two pre-calibrated force sensors, which have been specially designed to apply force to rat and mouse joints.
  • The device includes as standard both a control unit with two sensors of different sizes, and the NEW DCA software for signal monitoring, data transfer and analysis. Once saved, data can be browsed on the control unit and/or transferred to a PC in proprietary, Excel (.xls) or text (.txt) format, to be managed by most statistical analysis packages available on the market.
  • The PAM device can also be used to measure mechanical sensitivity in the mouse or rat paw, by using a specific Paw Pressure Transducer (optional).
The force is applied directly to the joint Direct measurent of evoked pain on the specific site
Pre-calibrated force transducers No calibration needed
Specifically designed for arthritis research The applicators are shaped for rodents knee and ankle
Paw pressure transducer as an optional PAM can also be used as a hand-held Randall-Selitto device
Foot pedal included Also manual scoring is possible for those cases when the automatic peak detector cannot be used



Via soft buttons and pedal


LCD Screen, via the DCA3 Software on the PC


Automatic start at pressure adjustable threshold

Stop Automatic at end of pressure, Automatic after a time limit (adjustable from 5 to 25 seconds), Manual by pedal

Force Ranges

0-500gf, 0-1500gf

Force Increasing Rate

Monitored via PAM Electronic Unit or via the DCA3 Software on the PC

Force Response

in 0.1gf steps

Latency Time

in 0.1s steps

Connection to PC      

via USB cable (A to mini-B) and PAM Software (DCA3)

Power Requirement

Either battery operated, via USB cable connected to PC, included power supply (100-240 VAC, 50-60Hz)

Operating Temperature

10°C to 40°C; 5% to 95% RH (non-condensing)

Sound Level




Total Weight


Shipping Weight

2.7Kg approx.

Dimensions 12(w)x15(d)x4,5(h) cm

Packing Dimensions




Warranty PAM is covered by a 12-month warranty + 12 after product registration
UB-Care Additional UB-Care can be added for other 12 or 24 months

The PAM applies a quantifiable force for direct stimulation of the joint delivering an automatic readout of the animal response.

The PAM was initially designed for Rheumatoid Arthritis, but it can obviously be used for many applications which aim at the assessment of the joint nociceptive threshold or at the threshold also in other parts of the body in rodents or large animals (with a special adapter).

Since its introduction, more than 10 years ago, dozens of papers have been published on several type of inflammation models and nociception studies in general (see references below). These include the most classic arthritis, fibromyalgia, induced joint damage, induced musculoskeletal pain, and many others.


38500 PAM Pressure Application Measurement


Electronic Unit   


Large Joint Transducer (Rat)


Small Joint Transducer (Mouse)


Pedal Switch for 38500, 38450, 47200


USB Cable

E-AU 059

Universal Power Supply

E-AU 101

USB pen-drive, including Instruction Manual and Software

38500-006 Paw Pressure Applicator

H. Tamai, M. Yamanaka, W. Taniguchi, N. Nishio, D. Fukui, T. Nakatsuka, H. Yamada, 2023, “Transient receptor potential ankyrin 1 in the knee is involved in osteoarthritis pain”, Biochemistry and Biophysics Reports

L. Singh, A.Kaur, S. Garg, A. P. Singh, R. Bhatti, 2020, “Protective Effect of Esc*letin, Natural Coumarin in Mice Model of Fibromyalgia: Targeting Pro-Inflammatory Cytokines and MAO-A”, Neurochemical Research

A. Obeidat, S. Ishihara, R. Miller, A.-M. Malfait, 2020, “Effect of systemically delivered zoledronic acid on joint damage, nociceptive knee innervation and pain after destabilization of the medial meniscus in mice”, Osteoarthritis and Cartilage

A.Kaur, L. Singh, N. Singh, M. S. Bhatti, R. Bhatti, 2019, “Ameliorative effect of imperatorin in chemically induced fibromyalgia: Role of NMDA/NFkB mediated downstream signaling”, Biochemical Pharmacology

P. Di Giminiani, S. A. Edwards, E.M. Malcom, M.C. Leach, M. S. Herskin, D. A. Sandercock, 2017, “Characterization of short- and long-term mechanical sensitisation following surgical tail amputation in pigs”, Nature

J. Leuchtweis, A.-K. Imhof, F. Montechiaro, H.-G. Schaible and M.K. Boettger, 2010, “Validation of the digital pressure application measurement (PAM) device for detection of primary hyperalgesia in rat and mouse antigen-induced knee joint arthritis”, Methods and Findings in Experimental and Clinical Pharmacology

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