Used to measure the paw withdrawal reflex when the mouse or rat paw is unexpectedly touched. For evaluating mechanical allodynia and cutaneous sensation levels. Popular non-invasive technique.
Set of 20 monofilaments based on the Semmes Weinstein monofilament set. An ascending series of increasingly stiff filaments (from 0.008 to 300 grams). Features retractable head to protect the filaments, allowing a researcher to carry a few around in a pocket. An optional perforated metal grid platform is available that is comfortable for the animal and easy for viewing the target area.
Especially suggested for sub-gram forces (i.e., severe allodynia) although very time consuming and operator dependent. Whenever possible, the use of the Electronic Von Frey or the Dynamic Plantar Aesthesiometer is suggested for higher throughput and better accuracy.
| Feature | Benefit |
|---|---|
| Starts from very low forceas (0.800 gr) | Detects even the most severe allodynia |
| Retractable filament | Easy to carry and protected from damage |
| Effective use in clinical setting | Used to diagnose pathologies of hyper- or hypo-aesthesia |
| Optional perforated platform available | For convenient stimulation of rodent plantar-surface |
Aesthesio® Tactile Sensory Evaluator Data Chart
When the tip of a fiber of given length and diameter is pressed against the skin at right angle, the force of application increases as long as the researcher continues to advance the probe, until the fiber bends. After the fiber bends, continued advance creates more bend, but not more force of application. The Semmes Weinstein set of monofilaments provides an approximately logarithmic scale of actual force, and a linear scale of perceived intensity. They have a long history of effective use in clinical settings, and can be used to diagnose pathologies of hyper- or hypo-aesthesia.
| Product | |
|---|---|
| 37450-275 |
Set of 20 monofilaments based on the Semmes Weinstein monofilament set, with Carrying case |
|
Optional | |
| 37450-278 | Base assembly for plantar stimulation, including support with columns, perforated metal sheet and multiple-configuration animal-enclosure, from 3 to 12 spaces |
| 37000-007 | Modular Animal Enclosure |
| 37450-045 | Large Perforated Metal Sheet, with 4 legs, 40cm height (animal enclosure 37000-007 is not included and should be ordered separately) |
| 37450-085 | Large Perforated Metal Sheet, with 4 legs, 80cm height (animal enclosure 37000-007 is not included and should be ordered separately) |
Xu et al., 2023, Vincamine as an agonist of G-protein-coupled receptor 40 effectively ameliorates diabetic peripheral neuropathy in mice, Acta Pharmacologica Sinica
N.M. Blebea et al., 2022, Evaluation of therapeutic potential of c*nnabidiolbased products in animal models of epileptic seizures, neuropathic pain and chronic inflammation, Farmacia Journal
Wang et al., 2021, Tetrahydropalmatine attenuates MSU crystal-induced gouty arthritis by inhibiting ROS-mediated NLRP3 inflammasome activation, International Immunopharmacology
Tsubaki et al., 2018, Trametinib suppresses chemotherapy-induced cold and mechanical allodynia via inhibition of extracellular-regulated protein kinase 1/2 activation, American Journal of Cancer Research
F. Stumpf et al., 2016, Metamiz*l Relieves Pain Without Interfering With Cerulein-Induced Acute Pancreatitis in Mice, Pancreas
In addition to the one-year Regular Warranty and in addition to the one-year product registration extended warranty, Ugo Basile offers an Optional Extended Warranty that extends the warranty period for the product for additional one or two years called “UB Care12”/“UB Care24”. Customers may purchase the “UB Care” at the maximum of 3 months after buying. For more detailed information, please contact your local representatives.
Thermal Conditioned Cabinet is an essential accessory for your TGR setup. It ensures optimal and stable environmental temperature from 0° up to 70° C (32° up to 158°F), improving test reliability and operator comfort. It holds up to two TGR units and provides insulation from light and noise, with built-in air suction and full connectivity to ANY-maze.
Thermal Conditioned Cabinet is an essential accessory for your TGR setup. It ensures optimal and stable environmental temperature from 0° up to 70° C (32° up to 158°F), improving test reliability and operator comfort. It holds up to two TGR units and provides insulation from light and noise, with built-in air suction and full connectivity to ANY-maze.
