In the late ‘80s Dr. Hargreaves invented a method to assess thermal pain sensation in unrestrained rodents by stimulating the single hind paw and thus allowing for unilateral/contralateral experiments. Ugo Basile made a science-grade instrument to perform this stimulation and automatically measure response, it became a gold-standard with more than 2,000 publications in 2022.

A thermal...

Touch sensitivity is traditionally tested with Von Frey filaments, which is a tedious and experimenter-dependent assay.

The Dynamic Plantar Aesthesiometer is a unique system, which fully automates the amount of force applied by an electromagnetic, silent motor exerting from 0 to 100 grams at a rate adjustable from 0 to 50 seconds.

When the animal responds, by withdrawing its...

Touch sensitivity in unrestrained animals is traditionally tested with Von Frey filaments, which is a tedious and experimenter-dependent assay.

The Electronic Von Frey system solves the multiple measurement (i.e. multiple filaments) issue and the experimenter bias by using a hand-held force sensor with a rigid metal. The scientist gradually increases the force applied to the animal...

Measures the weight distribution difference between an injured and unaffected hind paw of a mouse or rat. For the assessment of spontaneous pain in osteoarthritis, bone cancer, nerve injury and post-operative pain studies. Automatic operation reduces operator bias, optimizes repeatability and saves time. Easy to set up. Data visualization to monitor trends. Fast and easy cleaning...

Measures hypersensitivity to thermal (hot and cold) and/or mechanical stimulation of the orofacial area in rats (mouse adaptor available). For research into a wide range of pain conditions involving the trigeminal nerve.

High throughput with data recorded from up to 16 cages with ORO-Software. Real time data display. Non-invasive, respectful test. Comprehensive metrics and easy data...

The Thermal Place Preference test can be considered an evolution of the Hot/Cold plate test and it allows monitoring of temperature preferences by measuring the time spent in two compartments set at two different temperatures.

This two temperature nociception test can be used in a mouse or rat and is composed of a standard hot/cold plate and of an hot plate, connected by a corridor. It...

Accurately measures the nociceptive threshold to infrared heat stimulus on the rat or mouse tail. Used for rapid screening of analgesic drugs by measuring reaction time to heat, even in anesthetized animals, crucial for repeated tests, thanks to the reflexive nature of the tail flick response.

Adjustable I.R. intensity, bright touch-screen display with intuitive controls. Comfortable...

A positive pressure pump (according to Starling’s Ventilator method) for small animals. Assists with breathing during anesthesia and surgery or when an animal has an injury or illness that requires respiratory support.

A positive pressure pump (according to Starling's Ventilator method) for mice. Assists with breathing during anesthesia and surgery or when an animal has an injury or illness that requires respiratory support.

Highly accurate, rate displayed digitally, quiet, durable, high quality, long lifetime. Up to 300 strokes/min. Optimizes oxygenation by minimizing dead space. Range of...

A positive pressure pump (according to Starling's Ventilator method) for cats, rabbits and small animals of similar size. Assists with breathing during anesthesia and surgery or when an animal has an injury or illness that requires respiratory support.

Highly accurate rate displayed digitally, choice of cylinder/piston assemblies (50, 100 ml), quiet, robust, high quality, and long...

Provides and easy to use means of immobilizing an animal for surgery or procedures such as imaging. Gas Anesthesia (compared to injections) is a very quick way to induce total unconsciousness and also assists fast recovery.

High quality compact, modular and virtually unbreakable system. Reliable and precise delivery of the anesthetic gas to animals. Expandable system providing...

Measures the force on a rat or mouse paw according to the Randall-Selitto paw-pressure test, it enables rapid and precise screening of analgesic drugs for anti-nociceptive studies, in healthy or inflamed limbs. The device applies a steady increasing force, starting and stopping using the foot pedal. No calibration required. Digital model with force sensors and electronic unit is also...

Provides simple, reliable and precise calibration for Ugo Basile Plantar Test & Tail Flick and other infrared (I.R.) analgesia meters.

A warmer to provide external heat to animals undergoing surgery. Helps to maintain near-normal body temperature for improved surgical outcomes (such as fewer adverse cardiac events and reduced blood loss).

Preprogrammed animal temperatures, easy-to-use control, lightweight with small footprint. Select Rodent Warmer X2 for simultaneous control of 2 independent heating pads.

Evaluates the spasm-inducing effect of drugs. Typically assesses the effect of bronchodilation agents. Also used for screening substances inducing opposite effects.

Simple, reliable and fast method to assess airflow resistance. High precision recording of volume. Available as a complete set up with a rodent ventilator and data acquisition system.

Used to measure the paw withdrawal reflex when the mouse or rat paw is unexpectedly touched. For evaluating mechanical allodynia and cutaneous sensation levels. Popular non-invasive technique.

Set of 20 monofilaments based on the Semmes Weinstein monofilament set. An ascending series of increasingly stiff filaments (from 0.008 to 300 grams). Features retractable head to protect the...

Convenient, cost-effective solution to confine rodents and small animals for anesthesia procedures.

Models available in 2 sizes – smaller model for rodents and larger model for rabbits and similarly sized animals. Clear Perspex with a sliding lid. Quick connection to anesthesia or euthanasia systems using the 2 tubing connectors.

The hot cold plate test has been the gold standard test for thermal pain tests in rodents for decades. Through the years the devices have been improving and the techniques have become more sophisticated, adding to constant temperature methods also other ones.

The Ugo Basile Hot/Cold plate test includes all the latest technologies necessary to run constant temperature, linear ramping...

Set-shifting task has proven to be an effective preclinical tool for drug testing and genetic screening, with direct translational valence in healthy humans and patients with schizophrenia.

The Ugo Basile Operon automatizes the Intra-/Extra-dimensional (ID/ED) attentional set-shifting battery of tests offering visual, olfactory and tactile stimulations, all controlled by software and...

The Ugo Basile Fear Conditioning system is composed of:

• Isolation cubicle, including all electronics, fan, IR/VIS lights, camera (up to 16 cubicles can be connected to 1 PC)
• The animal cage is available in different dimensions for rats and mice, plus the observational learning version to allow two animals to see each other. The standard...

An essential instrument to measure current on Ugo Basile devices using electric shock grid, such the Fear Conditioning System, Active an Passive avoidance system.

Give the research the ability to measure the electric shock current not measurable by a common volt-meter. To ensure that the same current is delivered on multiple electric shock grids, while performing multiple test in...

Pre-pulse inhibition of the Startle reflex (PPI) is a phenomenon in which a weak stimulus (sound or light, or air-puff) suppress the startle response to a subsequent stronger startle stimulus (of the same kind).

The interest in this technique is mainly due to the fact that impairment in PPI is normally linked to a dysfunction in the sensorimotor mechanism, which has been shown in...

A set up for testing active avoidance (also called automatic reflex conditioner or shuttle box), i.e. learning to predict the occurrence of an aversive event, based on the presentation of a specific stimulus. Enables performance of a wide range of avoidance experiments using a flexible schedule. Precise detection of avoiding aversive event. Manage up to 4 cages with one controller.

The cubicle is a sound-attenuating chamber that isolates small animal subjects from distracting ambient light, sound and activity. For behavioral studies including operant behavior (Skinner), self-administration, etc.

High-level soundproof efficacy, noiseless fan, control box. Extra fixtures (speaker and video camera holder) for fear conditioning studies. Available in standard, large...

A classic way to assess short or long-term memory in small laboratory animals (rodents) using a fear-motivated avoidance task. Used routinely in animal model studies of aging and Alzheimer-type dementia, including the search for new therapeutic drugs.

An efficient, reliable instrument for use with mice (or small rats). A silent, automated sliding door divides compartments. Precision...

Passive Avoidance Test is used to assess memory function based on the association formed between a specific environmental context, which the animal learns to avoid and an aversive stimulus – represented by a mild foot shock.

Efficient and reliable. Silent, automated sliding door divides the dark and light compartments. Systems for mice or rats. Manage up to 4 cages with one...

When rodents are exposed to inescapable and unpredictable stress, such as forced swim or inescapable foot shock, they often develop deficits in memory and learning tasks (e.g. Active Avoidance) and they often show analgesic reactions (S.I.A. Stress-Induced Analgesia).

The Ugo Basile Set-Up for Learned Helplessness is based on a sophisticated generator of unpredictable random shocks...

A 2-compartment box that offers visual and tactile differences. For evaluating the abuse potential of substances and the motivational effects of drugs in mice or rats.

Interchangeable floors, optimized for use with video-tracking software or visual scoring, thanks to the grey, high-contrast color and non-smooth, non-reflective paint.