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  • Animal
    Mouse, Rat
    Plantar Test for Thermal Stimulation Hargreaves Apparatus

    In the late ‘80s Dr. Hargreaves invented a method to assess thermal pain sensation in unrestrained rodents by stimulating the single hind paw and thus allowing for unilateral/contralateral experiments. Ugo Basile made a science-grade instrument to perform this stimulation and automatically measure response, it became a gold-standard with more than 2,000 publications in 2022.

    A thermal...

    Animal
    Mouse, Rat

    Touch sensitivity is traditionally tested with Von Frey filaments, which is a tedious and experimenter-dependent assay.

    The Dynamic Plantar Aesthesiometer is a unique system, which fully automates the amount of force applied by an electromagnetic, silent motor exerting from 0 to 100 grams at a rate adjustable from 0 to 50 seconds.

    When the animal responds, by withdrawing its...

    Animal
    Mouse
    The mouse can freely move in the circular external lane base on his thermal preferences

    The TGR can clearly discriminate temperature-dependent phenotypes or temperature dependent drug effects.

    It records and analyses thermal preference phenotyping in mice. For neuropathic pain studies, peripheral neuropathy, temperature sensitivity and insensitivity assessment in basic research, phenotyping and drug screening.

    The animal is freely moving, its position is tracked...

  • Animal
    Mouse

    Set-shifting task has proven to be an effective preclinical tool for drug testing and genetic screening, with direct translational valence in healthy humans and patients with schizophrenia.

    The Ugo Basile Operon automatizes the Intra-/Extra-dimensional (ID/ED) attentional set-shifting battery of tests offering visual, olfactory and tactile stimulations, all controlled by software and...

    Animal
    Mouse, Rat

    Touch sensitivity in unrestrained animals is traditionally tested with Von Frey filaments, which is a tedious and experimenter-dependent assay.

    The Electronic Von Frey system solves the multiple measurement (i.e. multiple filaments) issue and the experimenter bias by using a hand-held force sensor with a rigid metal. The scientist gradually increases the force applied to the animal...

    Animal
    Mouse, Rat
    Videotracking
    Traditional

    Fear conditioning is one of the most common methods to measure memory in rodents. It exploits the Pavlovian association between an unpleasant unconditioned stimulus (shock) to a conditioned neutral stimulus (sound cue). The reaction of rodents, as predated animals, is to freeze (stay immobile) when exposed to fearful situations, such as a shock.

    Once the association has happened and...

  • Animal
    Mouse, Rat

    Pre-pulse inhibition of the Startle reflex (PPI) is a phenomenon in which a weak stimulus (sound or light, or air-puff) suppress the startle response to a subsequent stronger startle stimulus (of the same kind).

    The interest in this technique is mainly due to the fact that impairment in PPI is normally linked to a dysfunction in the sensorimotor mechanism, which has been shown in...

    Animal
    Mouse, Rat

    Measures the weight distribution difference between an injured and unaffected hind paw of a mouse or rat. For the assessment of spontaneous pain in osteoarthritis, bone cancer, nerve injury and post-operative pain studies. Automatic operation reduces operator bias, optimizes repeatability and saves time. Easy to set up. Data visualization to monitor trends. Fast and easy cleaning...

    Animal
    Rat

    Measures hypersensitivity to thermal (hot and cold) and/or mechanical stimulation of the orofacial area in rats (mouse adaptor available). For research into a wide range of pain conditions involving the trigeminal nerve.

    High throughput with data recorded from up to 16 cages with ORO-Software. Real time data display. Non-invasive, respectful test. Comprehensive metrics and easy data...

  • Animal
    Mouse, Rat
    Thermal Place Preference - complete system

    The Thermal Place Preference test can be considered an evolution of the Hot/Cold plate test and it allows monitoring of temperature preferences by measuring the time spent in two compartments set at two different temperatures.

    This two temperature nociception test can be used in a mouse or rat and is composed of a standard hot/cold plate and of an hot plate, connected by a corridor. It...

    Animal
    Mouse, Rat

    Measures small changes in volume & oedema (fluid retention) to gauge the inflammatory response such as for anti-inflammatory screening tests.

    Hands-free operation. Precision measurements. Detects and displays 0.01 ml changes in rodent paw volume. Easy data transfer and software included.

    Animal
    Mouse, Rat

    Accurately measures the nociceptive threshold to infrared heat stimulus on the rat or mouse tail. Used for rapid screening of analgesic drugs by measuring reaction time to heat, even in anesthetized animals, crucial for repeated tests, thanks to the reflexive nature of the tail flick response.

    Adjustable I.R. intensity, bright touch-screen display with intuitive controls. Comfortable...

  • Animal
    Mouse, Rat

    A set up for testing active avoidance (also called automatic reflex conditioner or shuttle box), i.e. learning to predict the occurrence of an aversive event, based on the presentation of a specific stimulus. Enables performance of a wide range of avoidance experiments using a flexible schedule. Precise detection of avoiding aversive event. Manage up to 4 cages with one controller.

    Animal
    Mouse, Rat

    The cubicle is a sound-attenuating chamber that isolates small animal subjects from distracting ambient light, sound and activity. For behavioral studies including operant behavior (Skinner), self-administration, etc.

    High-level soundproof efficacy, noiseless fan, control box. Extra fixtures (speaker and video camera holder) for fear conditioning studies. Available in standard, large...

    Animal
    Mouse

    A classic way to assess short or long-term memory in small laboratory animals (rodents) using a fear-motivated avoidance task. Used routinely in animal model studies of aging and Alzheimer-type dementia, including the search for new therapeutic drugs.

    An efficient, reliable instrument for use with mice (or small rats). A silent, automated sliding door divides compartments. Precision...

  • Animal
    Mouse, Rat

    Passive Avoidance Test is used to assess memory function based on the association formed between a specific environmental context, which the animal learns to avoid and an aversive stimulus – represented by a mild foot shock.

    Efficient and reliable. Silent, automated sliding door divides the dark and light compartments. Systems for mice or rats. Manage up to 4 cages with one...

    Animal
    Mouse, Rat
    The P.A.M. (Pressure Application Measurement) device is the original tool designed for measuring mechanical pain threshold on joint. It was specifically designed and validated for Arthritis research and is therefore especially suited to assess joint hypersensitivity in rodent knees or ankles. Once saved, data can be browsed on the control unit and/or transferred to a PC in proprietary, Excel or...
    Animal
    Mouse, Rat

    Measures the force on a rat or mouse paw according to the Randall-Selitto paw-pressure test, it enables rapid and precise screening of analgesic drugs for anti-nociceptive studies, in healthy or inflamed limbs. The device applies a steady increasing force, starting and stopping using the foot pedal. No calibration required. Digital model with force sensors and electronic unit is also...

  • Animal
    Mouse, Rat

    When rodents are exposed to inescapable and unpredictable stress, such as forced swim or inescapable foot shock, they often develop deficits in memory and learning tasks (e.g. Active Avoidance) and they often show analgesic reactions (S.I.A. Stress-Induced Analgesia).

    The Ugo Basile Set-Up for Learned Helplessness is based on a sophisticated generator of unpredictable random shocks...

    Animal
    Mouse, Rat

    Provides simple, reliable and precise calibration for Ugo Basile Plantar Test & Tail Flick and other infrared (I.R.) analgesia meters.

    Animal
    Mouse, Rat

    A 2-compartment box that offers visual and tactile differences. For evaluating the abuse potential of substances and the motivational effects of drugs in mice or rats.

    Interchangeable floors, optimized for use with video-tracking software or visual scoring, thanks to the grey, high-contrast color and non-smooth, non-reflective paint.

  • Animal
    Mouse, Rat

    The Porsolt Forced Swim Test (FST), or Porsolt Swim Test (PST), also known as the Behavioral Despair Test, is centered on the way rodents respond to their threat of drowning. This has been correlated to their mood, or, more precisely to their level of depression, with non-depressed animals that swim longer than depressed animals, who, instead, give up and float immobile.

    By...

    Animal
    Mouse, Rat

    The flexible rodent Lickometer - Vogel Test can operate as both a simple software-based lickometer as well as a system for drinking-conflict experiments (coupled with electric shocks). For assessing anxiety and the anxiolytic effect of drugs.

    Rat and mouse models. Easy data collection within the included software for windows. Up to 5 cages can be managed by 1 PC.

    Animal
    Mouse, Rat

    Used to measure the paw withdrawal reflex when the mouse or rat paw is unexpectedly touched. For evaluating mechanical allodynia and cutaneous sensation levels. Popular non-invasive technique.

    Aesthesio® set of 20 monofilaments based on the Semmes Weinstein monofilament set. An ascending series of increasingly stiff filaments (from 0.008 to 300 grams). Features retractable head to...

  • Animal
    Mouse, Rat

    Antidepressant drugs and depression animal model genetic screening are commonly conducted by using the Tail Suspension Test (TST). This test is based on the aversive effect of hanging a mouse of rat by the tail, which elicits its struggling moving upwards in an attempt to escape (which is obviously not possible).

    The struggling attempt tends to be shorter in duration and translates...

    Animal
    Mouse, Rat
    The Durham Holders are new rat holders for trigeminal stimulation, the newest accessory for use with the Plantar Test and Dynamic Plantar Aesthesiometer, manufactured by Ugo Basile.
    Animal
    Mouse, Rat

    The hot cold plate test has been the gold standard test for thermal pain tests in rodents for decades. Through the years the devices have been improving and the techniques have become more sophisticated, adding to constant temperature methods also other ones.

    The Ugo Basile Hot/Cold plate test includes all the latest technologies necessary to run constant temperature, linear ramping...