In the late ‘80s Dr. Hargreaves invented a method to assess thermal pain sensation in unrestrained rodents by stimulating the single hind paw and thus allowing for unilateral/contralateral experiments. Ugo Basile made a science-grade instrument to perform this stimulation and automatically measure response, it became a gold-standard with more than 2,000 publications in 2022.

A thermal...

Touch sensitivity is traditionally tested with Von Frey filaments, which is a tedious and experimenter-dependent assay.

The Dynamic Plantar Aesthesiometer is a unique system, which fully automates the amount of force applied by an electromagnetic, silent motor exerting from 0 to 100 grams at a rate adjustable from 0 to 50 seconds.

When the animal responds, by withdrawing its...

Touch sensitivity in unrestrained animals is traditionally tested with Von Frey filaments, which is a tedious and experimenter-dependent assay.

The Electronic Von Frey system solves the multiple measurement (i.e. multiple filaments) issue and the experimenter bias by using a hand-held force sensor with a rigid metal. The scientist gradually increases the force applied to the animal...

Measures the weight distribution difference between an injured and unaffected hind paw of a mouse or rat. For the assessment of spontaneous pain in osteoarthritis, bone cancer, nerve injury and post-operative pain studies. Automatic operation reduces operator bias, optimizes repeatability and saves time. Easy to set up. Data visualization to monitor trends. Fast and easy cleaning...

Measures hypersensitivity to thermal (hot and cold) and/or mechanical stimulation of the orofacial area in rats (mouse adaptor available). For research into a wide range of pain conditions involving the trigeminal nerve.

High throughput with data recorded from up to 16 cages with ORO-Software. Real time data display. Non-invasive, respectful test. Comprehensive metrics and easy data...

The Thermal Place Preference test can be considered an evolution of the Hot/Cold plate test and it allows monitoring of temperature preferences by measuring the time spent in two compartments set at two different temperatures.

This two temperature nociception test can be used in a mouse or rat and is composed of a standard hot/cold plate and of an hot plate, connected by a corridor. It...

Accurately measures the nociceptive threshold to infrared heat stimulus on the rat or mouse tail. Used for rapid screening of analgesic drugs by measuring reaction time to heat, even in anesthetized animals, crucial for repeated tests, thanks to the reflexive nature of the tail flick response.

Adjustable I.R. intensity, bright touch-screen display with intuitive controls. Comfortable...

A powerful complement to any stimulator. Delivers pulses for up to four preparations simultaneously. Adjustable polarity and intensity for each channel.

Designed for inducing convulsions in research mice and rats for epilepsy studies and many more e.g., neurochemical and neuropharmacological research such as evaluating the depressant or stimulating action of drugs on the CNS.

Reproducible results. Parameters have been selected as the most suitable range for mice or rats. Flexibility to extend your experiments by adding other...

Measures the force on a rat or mouse paw according to the Randall-Selitto paw-pressure test, it enables rapid and precise screening of analgesic drugs for anti-nociceptive studies, in healthy or inflamed limbs. The device applies a steady increasing force, starting and stopping using the foot pedal. No calibration required. Digital model with force sensors and electronic unit is also...

Provides accurate recording of isometric or isotonic tissue contraction/release. For studying effects of drugs or electrical stimuli on isolated smooth muscles (including uterus, trachea, gastrointestinal tract, vessel strips, auricle etc) under optimum conditions.

Classic pharmacology tool for research and teaching. Maintains the integrity of live muscle tissue for several hours in...

Compact, direct current (DC) Lesion Maker for localized electrolytic lesions in the brain.

Isolated, regulated DC output for electrical safety. Two operating modes: Continuous and Timed.

For stereotaxic surgery using rats or other small animals. Can be used to locate targets for implantation of devices, stimulation or injections.

Smooth, consistent movements with rapid positioning. Time-proven 'U'-Frame design provides stability and adaptability. Integrated warming base can be activated for better surgical outcomes.

The KDS Legato series is a range of advanced, precision syringe pumps. For applications requiring high metering precision at low, pulse-free flow rates.

Intuitive touch screen allows user to easily define complex injection protocols. Display presents real time data.

Provides accurate recording of isometric or isotonic tissue contraction/release. For studying effects of drugs or electrical stimuli on isolated smooth muscles (including uterus, trachea, gastrointestinal tract, vessel strips, auricle etc) under optimum conditions.

Classic pharmacology tool for research and teaching. Maintains the integrity of live muscle tissue for several hours in...

Provides precise information on the optimum day for mating during estrous cycle in the rats.

A powerful tool for improving reproduction efficiency. Simple, quick operation. Automatically calibrated when turned on. Designed for rats. A probe is available for mice.

Provides simple, reliable and precise calibration for Ugo Basile Plantar Test & Tail Flick and other infrared (I.R.) analgesia meters.

For investigating isotonic contractions (changes in tissue length) of isolated muscles and measuring small displacements in physiological preparations. Typically used to study the contractile/relaxation effects of drugs.

Perfect for studies using extremely small and fast muscle fibers. Set up a comprehensive system by adding our data acquisition system, organ baths, electrodes and...

Measures the force (or tension) of isolated tissue when its length is constant. Pharmacological responses can be characterized by the contractile/relaxant properties.

Four models available covering range from 0 to 50g. Highest-sensitivity model covers the range 0-800mg. Sturdy construction. Connects to popular data acquisition systems.

Untainted, reliable samples enabled by a unique funnel and cone design that effectively separates rodent feces and urine into tubes outside the cage.

Collection tubes are easy to remove and the process will not disturb the animals.

Used to measure the paw withdrawal reflex when the mouse or rat paw is unexpectedly touched. For evaluating mechanical allodynia and cutaneous sensation levels. Popular non-invasive technique.

Set of 20 monofilaments based on the Semmes Weinstein monofilament set. An ascending series of increasingly stiff filaments (from 0.008 to 300 grams). Features retractable head to protect the...

The hot cold plate test has been the gold standard test for thermal pain tests in rodents for decades. Through the years the devices have been improving and the techniques have become more sophisticated, adding to constant temperature methods also other ones.

The Ugo Basile Hot/Cold plate test includes all the latest technologies necessary to run constant temperature, linear ramping...

The TGR can clearly discriminates temperature-dependent phenotypes or temperature dependent drug effects.

It records and analyses thermal preference/avoidance in mice. For neuropathic pain studies, peripheral neuropathy, temperature sensitivity and insensitivity assessment in basic research, phenotyping and drug screening.

The animal is freely moving, its position is tracked by...

Measures small changes in volume & oedema (fluid retention) to gauge the inflammatory response such as for anti-inflammatory screening tests.

Hands-free operation. Precision measurements. Detects and displays 0.01 ml changes in rodent paw volume. Easy data transfer and software included.

Climbing behavior can be of interest for the most diverse applications.

The Ugo Basile automated system replicates its first manual application in the Pain field, for measuring Pain-Depressed behavior. It showed that, while mild analgesics block pain-depressed climbing, strong analgesics fail to alleviate depression of climbing (Santos et al. 2023, “Climbing behavior by mice as an...