The hot cold plate test has been the gold standard test for thermal pain tests in rodents for decades. Through the years the devices have been improving and the techniques have become more sophisticated, adding to constant temperature methods also other ones.

The Ugo Basile Hot/Cold plate test includes all the latest technologies necessary to run constant temperature, linear ramping...

Set-shifting task has proven to be an effective preclinical tool for drug testing and genetic screening, with direct translational valence in healthy humans and patients with schizophrenia.

The Ugo Basile Operon automatizes the Intra-/Extra-dimensional (ID/ED) attentional set-shifting battery of tests offering visual, olfactory and tactile stimulations, all controlled by software and...

The Ugo Basile Fear Conditioning system is composed of:

• Isolation cubicle, including all electronics, fan, IR/VIS lights, camera (up to 16 cubicles can be connected to 1 PC)
• The animal cage is available in different dimensions for rats and mice, plus the observational learning version to allow two animals to see each other. The standard...

An essential instrument to measure current on Ugo Basile devices using electric shock grid, such the Fear Conditioning System, Active an Passive avoidance system.

Give the research the ability to measure the electric shock current not measurable by a common volt-meter. To ensure that the same current is delivered on multiple electric shock grids, while performing multiple test in...

Pre-pulse inhibition of the Startle reflex (PPI) is a phenomenon in which a weak stimulus (sound or light, or air-puff) suppress the startle response to a subsequent stronger startle stimulus (of the same kind).

The interest in this technique is mainly due to the fact that impairment in PPI is normally linked to a dysfunction in the sensorimotor mechanism, which has been shown in...

A set up for testing active avoidance (also called automatic reflex conditioner or shuttle box), i.e. learning to predict the occurrence of an aversive event, based on the presentation of a specific stimulus. Enables performance of a wide range of avoidance experiments using a flexible schedule. Precise detection of avoiding aversive event. Manage up to 4 cages with one controller.

The cubicle is a sound-attenuating chamber that isolates small animal subjects from distracting ambient light, sound and activity. For behavioral studies including operant behavior (Skinner), self-administration, etc.

High-level soundproof efficacy, noiseless fan, control box. Extra fixtures (speaker and video camera holder) for fear conditioning studies. Available in standard, large...

A classic way to assess short or long-term memory in small laboratory animals (rodents) using a fear-motivated avoidance task. Used routinely in animal model studies of aging and Alzheimer-type dementia, including the search for new therapeutic drugs.

An efficient, reliable instrument for use with mice (or small rats). A silent, automated sliding door divides compartments. Precision...

Passive Avoidance Test is used to assess memory function based on the association formed between a specific environmental context, which the animal learns to avoid and an aversive stimulus – represented by a mild foot shock.

Efficient and reliable. Silent, automated sliding door divides the dark and light compartments. Systems for mice or rats. Manage up to 4 cages with one...

When rodents are exposed to inescapable and unpredictable stress, such as forced swim or inescapable foot shock, they often develop deficits in memory and learning tasks (e.g. Active Avoidance) and they often show analgesic reactions (S.I.A. Stress-Induced Analgesia).

The Ugo Basile Set-Up for Learned Helplessness is based on a sophisticated generator of unpredictable random shocks...

A 2-compartment box that offers visual and tactile differences. For evaluating the abuse potential of substances and the motivational effects of drugs in mice or rats.

Interchangeable floors, optimized for use with video-tracking software or visual scoring, thanks to the grey, high-contrast color and non-smooth, non-reflective paint.

The Porsolt Forced Swim Test (FST), or Porsolt Swim Test (PST), also known as the Behavioral Despair Test, is centered on the way rodents respond to their threat of drowning. This has been correlated to their mood, or, more precisely to their level of depression, with non-depressed animals that swim longer than depressed animals, who, instead, give up and float immobile.

By...

The flexible rodent Lickometer - Vogel Test can operate as both a simple software-based lickometer as well as a system for drinking-conflict experiments (coupled with electric shocks). For assessing anxiety and the anxiolytic effect of drugs.

Rat and mouse models. Easy data collection within the included software for windows. Up to 5 cages can be managed by 1 PC.

The Operant Fear Conditioning Cage couples a classic skinner box with sound and light cues for complex experiments, as well as standard operant tests and fear conditioning protocols.

Antidepressant drugs and depression animal model genetic screening are commonly conducted by using the Tail Suspension Test (TST). This test is based on the aversive effect of hanging a mouse of rat by the tail, which elicits its struggling moving upwards in an attempt to escape (which is obviously not possible).

The struggling attempt tends to be shorter in duration and translates...

The TGR can clearly discriminates temperature-dependent phenotypes or temperature dependent drug effects.

It records and analyses thermal preference/avoidance in mice. For neuropathic pain studies, peripheral neuropathy, temperature sensitivity and insensitivity assessment in basic research, phenotyping and drug screening.

The animal is freely moving, its position is tracked by...

Measures small changes in volume & oedema (fluid retention) to gauge the inflammatory response such as for anti-inflammatory screening tests.

Hands-free operation. Precision measurements. Detects and displays 0.01 ml changes in rodent paw volume. Easy data transfer and software included.

Enlargers for Mouse and Rat RotaRod are available to add multiple parameters to change the complexity of the experiment. Enlargers add-on for RotaRod come with grooves to increase the diameter of the rod or in smooth rubber to increase the diameter of the rod and change the surface from a grooved one to a smooth one. All the types of enlargers can be easily added to the rotating drum thanks to...

The complex wheel add-on for mouse and rat RotaRod introduces an additional complexity element for the animal to be tested. Thanks to the asymmetrical and adjustable bars it increases the test sensitivity and add a higher involvement of motor cortex and hippocampus, as compared to the classic rotarod test.

The Ugo Basile RotaRod is the 1st and original, invented after the Dunham and...

Climbing behavior can be of interest for the most diverse applications.

The Ugo Basile automated system replicates its first manual application in the Pain field, for measuring Pain-Depressed behavior. It showed that, while mild analgesics block pain-depressed climbing, strong analgesics fail to alleviate depression of climbing (Santos et al. 2023, “Climbing behavior by mice as an...