UB Care
Additional Warranty can be added to this product for other 12 or 24 months.
Discover more about our warranty policy.
Animal
Mouse, Rat
Thermal Place Preference for Rats and Mice
Product Code:35250/35260
Category: Pain and Inflammation
Identifies temperature sensitivity and nociceptive pain thresholds. For pathophysiological exploration of animal pain models and pharmacological assessment of analgesic drugs. Often called the Two-Temperature Choice Test.
Easy touch screen controls for setting up and monitoring tests. Fast data portability. Fixed or ramp temperatures for dynamic experiments.
Unlike the traditional cold/hot plate test, this test is operator-independent
Background
- Both heat and cold evoke thermosensation may elicit feelings of pain. Thermosensation is an essential sensory function which involves a variety of transducer molecules.
- The TPP (or 2-choice temperature test) is a thermal sensitivity assessment tool designed to emphasize integrated learned responses to thermal stimuli.
- Escape behavior (latency) in unrestrained animals to innocuous and noxious heating or cooling of the floor can be monitored.
- Unlike the traditional cold/hot plate test, this test is operator-independent. Rather than measuring the reaction time of an animal exposed to a certain temperature or ramp, the nociceptive response is provided by the animal as it chooses to move to its preferred position (comfort zone).
Dynamic experiments, easy control
- Easy touch-screen controls to set and visually monitor the test.
- An unrestrained animal (mouse or rats) can move freely between 2 circular compartments set at different temperatures. Temperature precision is 0.1°C.
- Fixed or ramping temperature for dynamic experiments
- Choose to make visual observations of animal response or use manual scoring software (ANY-maze Take Note).
- Detailed information on animal behaviour can be recorded automatically using ANY-maze software including time spent in each temperature zone, animal activity, zone trespassing, distance run by the animal (total or by zone). Other video tracking software can also be used.
- Data portability via the included USB Memory-Key
- The Ugo Basile TPP consists of:
- A Hot/Cold Plate
- An additional Hot Plate
- A set including special tubes, and a corridor for either mouse or rat to interconnect the two plates.
- Can be used as an independent Hot/Cold plate and Auxiliary Hot Plate.
|
Features |
Benefits |
|---|---|
|
Two-environment temperature test |
Easily monitor thermal place preference and nociceptive thresholds |
|
Unrestrained animals |
less stress for the animal, less user errors, integrated learned responses to thermal painful and non-painful stimuli |
|
Based on validated standard Ugo Basile devices |
Can be used as independent Hot/Cold Plate Device and Auxiliary Hot Plate |
|
Optional Videotracking System for automatic scoring and behavioral tracking |
Bias-free reproducible data |
|
Versatile device |
Allows flexibility of tests and methods |
|
General | |
|---|---|
|
Commands |
Hot/Cold Plate: 4”3 touch-screen (resistive), Hot Plate: Themoregulator panel |
|
Read-out |
On the touch-screen |
|
Power Requirement |
Universal input 85-264 VAC, 50-60Hz, 200W max. |
|
Sound Level |
Max 60 dB (A) |
|
Operating Temperature |
18° to 25°C |
|
Operation | |
|
Temperature |
Hot/Cold Plate: adjustable in the range -5.0 to 65.0°C, with 0.1°C increments Hot Plate: from room temperature to 65°C |
|
Precision |
+/- 0.1°C |
|
Mode |
Hot plate, cold plate, ramp (increasing or decreasing) |
|
Counting Start |
By START button or pedal switch |
|
Counting Stop |
By pedal switch |
|
Latency Time Counter |
Up to 999.9 seconds, in 0.1 steps |
|
Data Acquisition |
Via X-PAD software, provided |
|
Data Portability |
By USB flash drive, provided |
|
TTL Output |
For temperature and counter status |
|
Physical | |
|
Total Weight |
14Kg |
|
Shipping Weight |
20Kg approx. |
|
Dimensions |
50(w)x37(d)x47(h)cm – including restrainer |
|
Packing Dimensions |
68x34x28cm (two boxes) |
|
Warranty | |
| Warranty | 35250 / 35260 are covered by a 12-month warranty + 12 after product registration |
| Ub-Care | Additional UB-Care can be added for other 12 or 24 months |
Both heat and cold evoke thermosensation, which, if of sufficient intensity, may elicit feelings of pain. Thermosensation is an essential sensory function that is subserved by a variety of transducer molecules.
Well-established methods are available to measure thermal and mechanical sensitivity in awake behaving rodents, however, they require experimenter manipulations and tend to emphasize reflexive behaviors.
The TPP (or 2-choice temperature test), is a thermal sensitivity assessment tool designed to emphasize integrated learned responses to thermal painful and non-painful stimuli that are applied dynamically to a surface on which the animal is standing. It documents escape behaviour in awake, unrestrained animals to innocuous and noxious heating of the floor where the animal is located. Animals learn to minimize pain by escaping to the opposite non-heated side; escape latency can be recorded automatically.
(from 2005 Baliki et al, Molecular Pain 2005, 1:18 doi:10.1186/1744-8069-1-18)
|
35250 Thermal Place Preference Test, for Mice and small Rats | |
|---|---|
|
35250 |
Thermal Place Preference Test, for Mice and small Rats, standard package, complete. The Package includes a complete Hot/Cold Plate, a complete Auxiliary Hot Plate, and a corridor/TPP tube set for Mice 35250-003 |
|
35150 |
Hot/Cold Plate Test, complete |
|
35150-002 |
Auxiliary Hot Plate, complete |
|
35250-003 |
Set of Special Tubes and Catwalk for Mouse, for Thermal Preference set-up 35250, opening 45x95(h)mm |
|
35260 Thermal Place Preference Test, for Rats |
|
|
35150 |
Hot/Cold Plate Test, complete |
|
35150-002 |
Auxiliary Hot Plate, complete |
|
35260-002 |
Set of Special Tubes and Catwalk for Rat, for Thermal Preference set-up 35260, opening 87x110(h)mm |
|
Optional | |
|
60000-TN |
Software ANYmaze for manual scoring |
|
60000 |
ANYmaze videotracking system |
|
47400-040 |
USB camera |
Aziz Moqrich et alia: “Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin” Science 04 Mar 2005: Vol. 307, Issue 5714, pp. 1468-1472 https://science.sciencemag.org/content/307/5714/1468