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Pain and Inflammation

Pain and Inflammation

Estimates suggest that 20% of adults suffer from pain globally*. Chronic pain is the most common cause of long-term disabilities. From 1963 Ugo Basile’s devices have had a prominent role in research on pain & inflammation, precious tools for researchers to achieve their experimental goals.

* D. S. Goldberg and S. J. Mcgee, "Pain as a global public health priority"

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  • Animal
    Mouse, Rat

    In the late ‘80s Dr. Hargreaves invented a method to assess thermal pain sensation in unrestrained rodents by stimulating the single hind paw and thus allowing for unilateral/contralateral experiments. Ugo Basile made a science-grade instrument to perform this stimulation and automatically measure response, it became a gold-standard with more than 2,000 publications in 2022.

    A thermal...

  • Animal
    Mouse, Rat

    Touch sensitivity is traditionally tested with Von Frey filaments, which is a tedious and experimenter-dependent assay.

    The Dynamic Plantar Aesthesiometer is a unique system, which fully automates the amount of force applied by an electromagnetic, silent motor exerting from 0 to 100 grams at a rate adjustable from 0 to 50 seconds.

    When the animal responds, by withdrawing its...

  • Animal
    Mouse
    The mouse can freely move in the circular external lane base on his thermal preferences

    Records and analyses thermal preference phenotyping in mice, according to Zimmermann's method. For neuropathic pain studies, temperature sensitivity and insensitivity assessment, always with the animal freely moving and with no user’s intervention.

    Novel circular design. Addresses limitations associated with classic devices. Cost effective. Reproducible data.

  • Animal
    Mouse, Rat

    Touch sensitivity in unrestrained animals is traditionally tested with Von Frey filaments, which is a tedious and experimenter-dependent assay.

    The Electronic Von Frey system solves the multiple measurement (i.e. multiple filaments) issue and the experimenter bias by using a hand-held force sensor with a rigid metal. The scientist gradually increases the force applied to the animal...

  • Animal
    Mouse, Rat

    Measures the weight distribution difference between an injured and unaffected hind paw of a mouse or rat. For the assessment of spontaneous pain in osteoarthritis, bone cancer, nerve injury and post-operative pain studies. Automatic operation reduces operator bias, optimizes repeatability and saves time. Easy to set up. Data visualization to monitor trends. Fast and easy cleaning...

  • Animal
    Rat

    Measures hypersensitivity to thermal (hot and cold) and/or mechanical stimulation of the orofacial area in rats (mouse adaptor available). For research into a wide range of pain conditions involving the trigeminal nerve.

    High throughput with data recorded from up to 16 cages with ORO-Software. Real time data display. Non-invasive, respectful test. Comprehensive metrics and easy data...

  • Animal
    Mouse, Rat
    Thermal Place Preference - complete system

    Identifies temperature sensitivity and nociceptive pain thresholds. For pathophysiological exploration of animal pain models and pharmacological assessment of analgesic drugs. Often called the Two-Temperature Choice Test.

    Easy touch screen controls for setting up and monitoring tests. Fast data portability. Fixed or ramp temperatures for dynamic experiments.

  • Animal
    Mouse, Rat

    Measures small changes in volume & oedema (fluid retention) to gauge the inflammatory response such as for anti-inflammatory screening tests.

    Hands-free operation. Precision measurements. Detects and displays 0.01 ml changes in rodent paw volume. Easy data transfer and software included.

  • Animal
    Mouse, Rat

    Accurately measures the nociceptive threshold to infrared heat stimulus on the rat or mouse tail. Used for rapid screening of analgesic drugs by measuring reaction time to heat, even in anesthetized animals, crucial for repeated tests, thanks to the reflexive nature of the tail flick response.

    Adjustable I.R. intensity, bright touch-screen display with intuitive controls. Comfortable...

  • Animal
    Mouse, Rat
    The P.A.M. (Pressure Application Measurement) device is the original tool designed for measuring mechanical pain threshold on joint. It was specifically designed and validated for Arthritis research and is therefore especially suited to assess joint hypersensitivity in rodent knees or ankles. Once saved, data can be browsed on the control unit and/or transferred to a PC in proprietary, Excel or...
  • Animal
    Mouse, Rat

    Measures the force on a rat or mouse paw according to the Randall-Selitto paw-pressure test, it enables rapid and precise screening of analgesic drugs for anti-nociceptive studies, in healthy or inflamed limbs. The device applies a steady increasing force, starting and stopping using the foot pedal. No calibration required. Digital model with force sensors and electronic unit is also...

  • Animal
    Mouse, Rat

    Provides simple, reliable and precise calibration for Ugo Basile Plantar Test & Tail Flick and other infrared (I.R.) analgesia meters.

  • Animal
    Mouse, Rat

    Used to measure the paw withdrawal reflex when the mouse or rat paw is unexpectedly touched. For evaluating mechanical allodynia and cutaneous sensation levels. Popular non-invasive technique.

    Aesthesio® set of 20 monofilaments based on the Semmes Weinstein monofilament set. An ascending series of increasingly stiff filaments (from 0.008 to 300 grams). Features retractable head to...

  • Animal
    Mouse, Rat
    The Durham Holders are new rat holders for trigeminal stimulation, the newest accessory for use with the Plantar Test and Dynamic Plantar Aesthesiometer, manufactured by Ugo Basile.
  • Animal
    Mouse, Rat

    The hot cold plate test has been the gold standard test for thermal pain tests in rodents for decades. Through the years the devices have been improving and the techniques have become more sophisticated, adding to constant temperature methods also other ones.

    The Ugo Basile Hot/Cold plate test includes all the latest technologies necessary to run constant temperature, linear ramping...

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