The RotaRod is a simple test to assess motor function and coordination in rodents. Motor coordination or fatigue can be evaluated by measuring the time the animal stays on a rotating rod before falling. The Rod can rotate at constant, accelerating, rocking (back and forth) or through complex acceleration/deceleration ramps, thanks to the included PC software XPad.
The Ugo Basile Large Rat RotaRod consists of a 8 cm diameter rod, suitably machined to provide grip. Five flanges divide the four 12 cm lanes, enabling four rats to be simultaneously on test. When a rat falls off its rod section into the trip-box below, its endurance in RPMs is recorded. Height to fall is 40 cm.
The Ugo Basile RotaRod is the 1st and original, invented after the Dunham and Miya method (1957) and today has more than 6,200 citations in the literature.
The rotarod test, invented by Dunham and Miya (1957) and transformed into a science-grade device by Ugo Basile, is one of the oldest used in assessing the effects of a drug on animal behavior. Today it is obviously used in phenotyping and not only in drug screening.
Drugs (e.g. benzodiazepines) or specific phenotypes alter neuromuscular coordination and hence the time that the mouse or rat remains on the rotating rod.
Multiple animals can be tested at the same time and several protocols exist to train and assess the motory coordination through the falling time.
The output results include for each lane:
|
Feature |
Benefit |
|---|---|
|
Constant, rocking, accelerating and complex accelerating ramps |
Flexibility for performing virtually all types of motor function and coordination behavioral experiments |
|
Mouse-Rat combination package |
The same device cannot be used effectively (think of cleaning) on rats and mice without risk of confounding factors, so a highly discounted package is available for those that buy the two models. |
|
Speed adjustable from 3 to 80 RPMs and multiple modes (constant, rocking, accelerating, complex accelerating ramps) |
Allows for a very broad range of animal models and experimental settings |
|
Control unit and USB key saving |
No need to connect a PC |
| Automatic conversion of data into CSV files for the USB stick | Possibility to open files in Excel |
| PC software | Possibility to populate your vivarium of animals and to build complex temperature ramps |
|
General | |
|---|---|
|
Commands |
4,3” touch-screen, usable with gloves |
|
Read-out |
Touch-screen and PC (via USB key) |
|
Power Requirement |
Universal input 100-240 VAC, 50-60Hz, 40W max. |
|
Sound Level |
< 60 dB (A) |
|
Operating Temperature |
10° to 40° C |
| Trip Box | Stainless-steel to ease sterilization |
| Dimensions | |
| Lanes | 4 lanes |
| Rod diameter | 8 cm |
| Rod Width | 12 cm |
| Fall Height | 40 cm |
|
Operation | |
|
Speed |
Adjustable from 3 to 80 RPM, in steps of 1 RPM (Custom ramp mode allows start from 0RPM) |
|
Mode |
Constant, ramp, reverse ramp, custom ramp and rocking |
|
Start/Stop |
From the touch-screen |
|
Detection |
Trip box magnetic sensor |
|
Results |
Time Elapsed, Revolutions, Distance, Speed, Mode for each lane |
|
Data Acquisition |
.csv exported file (via USB key) |
|
Data Portability |
By USB flash drive |
|
TTL Output |
Trip box status, rotating direction, start/stop experiment |
|
Data Out |
exported to .cvs |
|
Data In |
Import protocol and custom ramps |
|
Physical | |
| Total Weight | 17 Kg |
| Shipping Weight | 40 Kg |
| Dimensions | 70 x 46 x 65 cm |
| Packing Dimensions | 77 x 65 x 83 cm |
| Warranty | |
| Warranty | Large Rat RotaRod are covered by a 12 months warranty + 12 months upon product registration |
| UB-Care | Additional UB-Care can be added for additional 12 or 24 months |
The RotaRod test is commonly used in combination with other motor tests, such as grip strength and hanging test to measure, motor function, coordination and balance.
The test starts with a training trial with the animals placed on the rod rotating at the lowest speed. A time threshold (e.g. 1 minute) is set, below which the animal is immediately put back on the RotaRod until it stays on the rod for the threshold time.
After training, the real trials start and the latency to fall as well as the other parameters (see above) are recorded.
The classic test was run at constant speed, but already in the ‘60s (Jones and Roberts, 1968), the advantages of using accelerating modes were shown, such as training reduction, increased sensitivity and statistical significance improvement.
The test is used to test motor deficits in the most common animal models of Parkinson’s, ALS, Huntington’s disease, multiple sclerosis, brain injury and all models where motor coordination and function is to be investigated.
|
RotaRod | |
|---|---|
| 47750-D01 Large Rat RotaRod | Large Rat RotaRod with USB output and USB flash drive (E-AU 101), including instruction Manual and X-PAD Software Package |
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Optionals | |
| 47750-D01-UBC12 | UB Care 12 Additional hardware warranty extension 12 months for Large Rat RotaRod (Valid for SKU 47750-D01) |
| 47750-D01-UBC24 | UB Care 24 Additional hardware warranty extension 24 months for Large Rat RotaRod (Valid for SKU 47750-D01) |
In addition to the one-year Regular Warranty and in addition to the one-year product registration extended warranty, Ugo Basile offers an Optional Extended Warranty that extends the warranty period for the product for additional one or two years called “UB Care12”/“UB Care24”. Customers may purchase the “UB Care” at the maximum of 3 months after buying. For more detailed information, please contact your local representatives.
