Pain and inflammation
Code: 35150

Hot/Cold Plate NG for screening of thermal hyperalgesia/allodynia

The new Hot/Cold Plate NG offers a wide temperature range, presettable in the range -5°C to 65°C and is very quick and precise in reaching and keeping the preset temperature. 

The 35150 can be used as a conventional HOT PLATE, to carry out a rapid precise screening of narcotic type analgesic drugs according to the well known Hot Plate Test devised by N.B. Eddy and D. Leinbach.

As a COLD PLATE; the Cold Plate Test is useful in studying cold receptors and cold allodynia, a phenomenon very frequently observed in chronic pain on humans.
The lid reduces humidity condensation on the plate at low temperatures. Two working modes allow for testing at fixed temperature or at increasing/decreasing temperature (RAMP).

Brand new, user friendly software, to set up the experiment and manage the results.

An “auxiliary” Hot Plate, Cat. No. 35150-002, can be supplied as an optional, useful in the training and acclimation phase, for high-throughput tests. The 35160 combo-package, which includes a 35150 Hot/Cold Plate and a 35150-002 Hot Plate, can be taken into consideration.

Additional Info

    • OPERATING TEMPERATURE: -5.0°C to 65.0°C in steps of 0.1°C, with a precision of 0.5°C
    • DETECTION: by pedal switch
    • OPERATING MODES: fixed or ramping temperature, for dynamic experiments
    • X-PAD SOFTWARE: brand new, user friendly software included as standard, to set up the experiment and manage the results
    • CONTROLS: 4”3 touch-screen to set and monitor the test
    • DATA PORTABILITY: via the USB Memory-Key, included




    4”3 touch-screen (resistive)


    on the touch-screen

    Power Requirement

    Universal input 85-264 VAC, 50-60Hz, 40W max.

    Sound Level

    < 60 dB (A)

    Operating Temperature

    18° to 25°C see paragraph 2.1.1




    adjustable in the range -5.0 to 65.0°C, with 0.1°C increments


    +/- 0.1°C


    hot plate, cold plate, ramp (increasing or decreasing)

    Counting Start

    by START button or pedal switch

    Counting Stop

    by pedal switch

    Latency Time Counter

    up to 999.9 seconds, in 0.1 steps

    Data Acquisition

    via X-PAD software, provided

    Data Portability

    by USB flash drive, provided

    TTL Output

    for temperature and counter status


    exported to Text, Excel or Pdf, or saved to cloud to DropBox, OneDrive, GoogleDrive


    exported to Text, Excel or Pdf, or saved to cloud to DropBox, OneDrive, GoogleDrive



    Total Weight


    Shipping Weight

    12Kg approx.


    25(w)x37(d)x47(h)cm – including restrainer

    Packing Dimensions



    35150 is covered by a 24-month warranty


    An “auxiliary” conventional Hot Plate 35150-002 is available as optional; this self-standing unit may be used for the habituation phase before the test, thus reducing the use of the main unit to the test proper.

    The hot plate tests the pain response in animals, used in basic pain research and in testing the effectiveness of analgesics by observing the reaction to pain caused by heat.

    The method, devised by N.B. Eddy and D. Leimbach in 1953 (see paragraph 8.1-Method Papers) evaluates the reaction time of mice dropped on a heated surface and thus confronted with a heat stimulus applied to the plantar surface.

    Eddy and Leimbach used a behavioral model of nociception where behavior such as jumping and hind paw-licking are elicited following a noxious thermal stimulus. Licking is a rapid response to painful thermal stimuli that is a direct indicator of nociceptive threshold. Jumping represents a more elaborated response, with a latency, and encompasses an emotional component of escaping.

    When a central analgesic agent is administered to the animals, reaction time is markedly increased.

    The new Hot/Cold Plate 35100 has been designed to study more recently published cold receptor systems of neurons, which are not activated by cold but rather by chemicals, as well as the traditional cold receptors. These neurons are present in the CNS as well as PNS, but they are different from the neurons which sense pain.

    35150 Hot/Cold Plate, complete with standard accessories
    35150-001 Cabinet (controller with touch-screen and Plate assembly)
    35100-286 Cylindrical Animal Restrainer, for Mice and Rats, 25cm height
    35150-320 Restrainer Lid
    37215-303 Pedal Switch
    E-AU 041 USB pen drive, including:

    35150-302   Instruction Manual  

    X-PAD  Dedicated Software Package

    E-WP008 Mains Cord – Europe (or E-WP008-1 U.S.A. / E-WP008-2U.K.)
    35150-002 Additional Hot Plate
    35160 Combo package 35150 and 35150-002 
    35250-003 Set of Tubes/Catwalk for 35250
    35250 / 35260 Thermal Place Preference
    • N.B. Eddy & D. Lembach: “Synthesis, Anti-Inflammatory and Analgesic Activity of Pyrido [2, 1-b] Quinazoline Derivatives” J Pharma Exp 953: 703-385, 1953

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