Behaviour, Conditioning, Reward
Code: 40570

Passive Avoidance - step down (vibrating platform) for Mice

The Passive Avoidance step-down cage, for mice or immature rats, is based on the stepdown scheme in which the animal is dropped on an elevated platform which becomes uncomfortable because of vibrations.

The instrument basically consists of an arena, shaped as a cage (Cat. No. 47573) and a control unit with touch-screen 40500-001, with the related application software 40570-010.

The P.A. set-up is part of UB conditioning-cage project; you buy a single touch-screen controller, and manage all UB cages. Ask for details!

A 7 cm platform elevated above the floor grid of a 28x23cm box provides the arena for Step-Down experiments. The platform is connected to an actuator which causes the platform to shake. When the animal steps off of the platform to the electrified grid, the stop command is used to cut actuator power, halt platform vibration, and trigger the latency counter.
Latency time is recorded to 1/10 of a second. The vibration intensity is selectede from 10 to 10Hz, in 10 steps (10Hz each). The shock intensity can be preset in the range 0 to 3mA, in steps of 0.1mA. A delay up to 15 seconds can be set in steps of 1s.

Additional Info

    Part of the BEEHIVE SYSTEM the electronic unit encompasses all controls for up to 4 animal cages!
    Retention latency detection Recorded down to 0.1seconds
    Specifically designed for Mice and premature Rats Two platforms supplied with the instrument
    Remote Control feature Makes remote service and software upgrades extremely simple!
    Great Versatility The same controller can manage different conditioning tests. Ask for details!
    Touch Screen Controller
    LCD 12” with resistive touch screen
    CPU Module Port 2 USB Port 2.0; 1 Ethernet port 10/100Mb;1 DVI port for external monitor
    Peripheral Port 4 output for Sound, Shock and  light; 1 Power supply 12V-2A
    Expansion Bus         Connection 2 RJ11 connectors
    Shock Constant current
    Shock Intensity from 0 to 3mA, in 0.1mA steps
    Platform Vibration 10-100Hz, in 10Hz steps
    Vibration Width 0-10, in steps of 1
    Vibration Delay 0-15 seconds, in 1s steps
    Operating Temperature 10° to 40°C
    Sound Level Negligible
    Pollution Degree ≤ 2
    Number of Cages Up to 4 (with expansion boxes)

    25(d)x33(w)x5.5(h)cm (40500-001)

    28(w)x23(d)x26(h)cm (40573)


    2.7Kg (40500-001)

    3.5 (40573)  

    Shipping Weight

    4Kg (40500-001)

    6Kg (40573)

    Packing Dimensions 80x60x44cm (Control Unit & one cage)
    Warranty 40570 is covered by a 24-month warranty






    Physical Dimensions:  
    Dimensions (40500-001): 33(w) x 25(w) x 5.5(h)cm
    Dimensions (47573): 28(w) x 23(d) x 26(h)cm
    Packing Dimensions: 80x60x44cm
    Weight: Kg  8
    Shipping Weight: Kg 16 (approx.)

    Behavioral scientists are well acquainted with passive avoidance methods that have been used for several decades, originally by psychologists, who were interested in animal behavior.

    These procedures were later exploited by neuroscientists, who specifically perform sys-tematic studies of the behavioral changes mainly produced by brain lesions, to define the functions of different C.N.S. sections.

    The Passive Avoidance was soon extended to several other areas of research such as behavior genetics, psychopharmacology and behavioral toxicology.

    More recently, such use has become routine in animal model studies of aging and of Alz-heimer-type dementia, including the search for new drugs of potential therapeutic value, consisting of attenuation of behavioral deficits.

    The Passive Avoidance task is a one trial fear-motivated avoidance task, classically used to assess short-term or long-term memory on small laboratory animals (rodents).

    Passive Avoidance is a broad term that includes an ample selection of methods and an equally wide variety of different versions of each method.

    In our Passive Avoidance instrument one exploits the tendency to step down from a vi-brating, hence definitely uncomfortable floor section.

    40500-001 Controller with Touch Screen and 8-pole Scrambling Shocker
    40570-010 Software and activation for Passive Avoidance Test

    P.A. Mouse Cage, step-down

    47573-320 7cm diam. Platform

    47573-321 11cm diam. Platform

    52010-323 USB Cable
    E-AU 041 USB pen-drive, including
    40570-302      Instruction Manual 


    The following is an example of configuration of a 4-Cage Mouse set-up:

    1 40500-001 Controller with Touch Screen and 8-pole Scrambling Shocker
    40550-010 Software and activation
    4 40753 P.A. Mouse Cage
    3 40500-005 Expansion Box (one is required for each additional cage)

    Bibliography on 40570

    • Rhodiola rosea L-Standardized Extract on Passive Avoidance in Rats LV Vasileva, DP Getova, 2017
    • A. Mikulecká et alia: “Consequences of early postnatal benzodiazepines exposure in Rats. I. Cognitive-like be­havior” Front. Behav. Neuroscience 8 : 101, 2014
    • I.K. Celikyurt et alia: “Effect of harmane, an endogenous β-carboline, on learning and memory in rats” Pharma­col.Biochem.Behav 103:666-671, 2013
    • M.T. Georgieva-Kotetarova et alia: “Effect of atorvastatin and rosuvastatin on learning and memory in rats with diazepam-induced amnesia” Folia Med 55(2): 58-65, 2013
    • D.S. Dimitrova & D.P. Getova-Spassova: “Effects of Galan­tamine and Donepezil on Active and Passive Avoidance Tests in Rats With Induced Hypoxia” J. Pharmacol. Scien­ces 101 : 199-204, 2006
    • M. Sakaguchi et alia: “Effects of beta-casomorphin-5 on passive avoidance response in mice“ Biosci.Biotechnol. Biochem 67 (11): 2501-2504, 2003

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