Ugo Basile RotaRod cited in Nature Communications

Our flagship RotaRodhas been cited in the high-impact paper "𝐀𝐜𝐨𝐮𝐬𝐭𝐨𝐟𝐥𝐮𝐢𝐝𝐢𝐜 𝐛𝐢𝐨𝐚𝐬𝐬𝐞𝐦𝐛𝐥𝐲 𝐢𝐧𝐝𝐮𝐜𝐞𝐝 𝐦𝐨𝐫𝐩𝐡𝐨𝐠𝐞𝐧𝐞𝐬𝐢𝐬 𝐟𝐨𝐫 𝐭𝐡𝐞𝐫𝐚𝐩𝐞𝐮𝐭𝐢𝐜 𝐭𝐢𝐬𝐬𝐮𝐞 𝐟𝐚𝐛𝐫𝐢𝐜𝐚𝐭𝐢𝐨𝐧", recently published in Nature Communications. This research represents a major advancement in tissue engineering and regenerative medicine.

The authors introduce a novel technique called acoustofluidic bioassembly, that enables precise arrangement and aggregation of cells by combining acoustic waves and fluidic forces. This innovative method replicates the spatial cellular architecture observed during embryonic morphogenesis, a key challenge in building functional in vitro tissues for therapeutic applications. Using acoustofluidic bioassembly, the researchers successfully fabricated neuromuscular tissues with aligned muscle progenitor cells and motor neurons. Remarkably, when implanted in mice with volumetric muscle loss, these tissues significantly restored both structural integrity and functional performance of the hindlimb. The study shows that cell alignment and density, key factors in tissue maturation, can be precisely controlled using acoustofluidic cues. The acoustofluidic bioassembly fabricated tissues not only improved muscle contractility and electrophysiological activity in vitro, but also restored gait, grip strength, and weight-bearing ability in vivo. These functional improvements were rigorously assessed through several behavioral assays, including the RotaRod test, where the latency to fall from a rotating rod provided quantifiable metrics of motor coordination and endurance.

To assess the therapeutic efficacy of the implanted tissues, the Ugo Basile RotaRod was used to measure neuromuscular function over time. Mice treated with acoustofluidic bioassembly fabricated tissues showed progressive improvements. The RotaRod’s precise and reliable readouts made it the ideal tool to monitor motor recovery in this groundbreaking study.

Read the full article here: https://www.nature.com/articles/s41467-025-59026-4 Ugo Basile RotaRod is the gold standard for motor coordination studies, originated by a 1957 paper of N.W. Dunham and T.S. Miya and transformed into a sciencegrade device by Ugo Basile. A complete range of accessories to modify the difficulty, complexity and sensitivity of the test available:

Ugo Basile RotaRod for mice and rats ➡️ https://ugobasile.com/products/categories/motory-coordination/rotarod-for-mice-and-rats

Complex Wheel for RotaRod Family ➡️ https://ugobasile.com/products/categories/complex-wheel

Enlargers for mouse and rat RotaRod ➡️ https://ugobasile.com/products/categories/motory-coordination/enlargers-for-mouse-and-rat-rotarod

Discover the full range of Ugo Basile instruments for motor coordination studies ➡️ https://ugobasile.com/results/?q=&virtuemart_category_id[]=35