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Mouse, Rat

Blood Pressure Recorder - Non Invasive

Product Code:58500/58550/58600
Category: Blood pressure

A multi-function, non-invasive blood pressure recorder for small to medium animals (mice to dogs) for use in a wide range of scientific studies, where systolic and diastolic pressure needs to be measured in a non-invasive way in anesthetized or awake animals.

Combines functionality of multiple systems including pressure generation-pressure monitoring system, pulse amplifier, thermal-array analog and digital recording unit and more. Single turn-key, stand-alone solution that can also be connected to popular data acquisition systems, like our Data Capsule for better visualization and analysis. A rat or mouse restrainer is supplied. Other accessories available, like animal wamers, holders, etc...

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This product warranty can be extended up to 24 Additional Months.
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Non-invasive techniques are in line with the principles of the Three Rs (Replacement, Reduction, Refinement) in animal research. By using non-invasive methods, researchers can obtain valuable data without resorting to more invasive procedures, reducing animal distress and the number of animals needed for experiments.

Ugo Basile, as a manufacturer of preclinical research instruments, provides specialized tools that are designed to accurately and reliably measure non-invasively blood pressure in small animals, aiding researchers in obtaining high-quality data for their studies.

Invasive blood pressure measurements are not applicable to many areas of cardiovascular research, as many diseases and conditions, such as hypertension, heart disease, and stroke, are closely linked to changes in blood pressure, when its measurement requires surgical intervention. Researchers need accurate and non-invasive methods to study these conditions in animal models to better understand their mechanisms, progression, and potential treatments.

In addition to what described above, invasive methods frequently require anesthesia, which affects blood pressure, cause stress and influence experimental outcomes, Limiting the translational value of the studies. Moreover, animal welfare and ethical considerations are more and more important, as well as limiting the risk of complications such as infections, tissue damage, bleeding.

From the accuracy standpoint non-invasive methods are more adaptable to the different animal sizes variation and their versatility allows to compensate also for anatomical differences.

Multi function, non-invasive recorder

A reliable pressure generator, provides smooth and stepless pressure build-up.

A “Riva Rocci sphygmomanometer” provides a precise recording of the systolic and diastolic blood pressure. It works by transmitting pressure to the tail cuff to obtain accurate systolic and diastolic pressure readings that are digitally presented in 10 mm Hg steps. The animal pulse rate can be assessed in real time by a pulse rate counter, which picks the signal from the pulse transducer.

The Ugo Basile non-invasive Blood Pressure system combines functionality of multiple systems in a single turn-key, stand-alone solution thanks to:

    • A pressure generation-pressure monitoring system
    • A pulse amplifier 
    • A thermal-array analog and digital recording unit 
    • Pulse rate measuring and recording
  • Microprocessor controlled functions to self-diagnosis, calibration, signal filtering, signal storage.
  • Wide range of tail transducer sizes (4-18 mm) adapts to small to medium sized animals (mice-dogs).
  • Internal memory and PC output (BNC already amplified).
  • Can be connected to popular data acquisition systems including our DataCapsule-Evo Recorder
  • A mouse or rat restrainer is provided with each package.
  • Optional animal restrainers by Ugo Basile are available featuring conical “muzzle” for confining the head, availability in 4 different diameters to fit various animal sizes with telescope-adjustable length, a quick fit/release back lid with an ample U-shaped tail slot, ventilation slots and selection of heat conductive materials to guarantee body heat dissipation. Ask for details.
  • Optional rodent temperature controlled heating boxes available for rats and mice. The air temperature can be set from room temperature to 39.9°C, in 0.1°C steps.



Internal memory an PC output

Turn-key and stand-alone

Analogue output (BNC)

Can be conncted to external data acquisition systems without amplification need

Wide range of tail transducer sizes (4-18 mm)

Adapts to different animal weights

Algorithm for diastolic and systolic pressure The experimenter can rely on the electronically-driven assessment of pressure parameters and heart rates.


via the START key on the front panel

Pressure Range

50 to 290 mm Hg

Power Requirements

115 or 230 V, 50/60 Hz, 25 W max

Operating Temperature

0° to 40° C

Sound Level

< 70 dB

Physical Dimensions

Weight (net) 

Kg   10.6

Shipping Weight

Kg   15.0 approx


35 x 35 x 16.5 (h) cm

Packing dimensions

67 x 42 x 53 cm

The non-invasive Blood Pressure recorder is a very versatile device which can be used in a very large number of scientific settings:

  • Cardiovascular research: to assess how blood pressure is affected by other factors, from the environment, to the genotype or drugs and toxic agents, rather than diet, exercise, aging.
  • Hypertension research: high blood pressure is a major concern worldwide and mice and rats are models to study development, progression and treatment of hypertension.
  • Drug Development and Genetic Screening: drugs can be screened for positive effect on blood pressure or to ensure they do not have counter-effects, as well as blood pressure is almost always part of the battery of tests which are run during phenotyping or during studying disease models.
  • Metabolic research: blood pressure is strictly linked to metabolic rates and health. Non-invasive blood pressure measurement is used to explore the relationship between diabetes, obesity and cardiovascular function
  • Cyrcadian rhythm studies, as blood pressure fluctuates over the day and non-invasive measurement of it aids in understanding how these rhythms are regulated and how they influence overall health.
58800 BP RECORDER, with accessories for RAT: 8mm pulse pick-up, 13mm cuff, 50mm holder
58850 BP RECORDER, with accessories for MOUSE: 3mm pulse pick-up, 6mm cuff, 30mm holder
58900 BP RECORDER, with accessories for RAT & MOUSE
58000-503 Pulse Pick-up for Mouse, diam. 3 mm 
58000-504 Pulse Pick-up for Mouse, diam. 4 mm
58000-505 Pulse Pick-up for Rat, diam. 5 mm
58000-506 Pulse Pick-up for Rat, diam. 6 mm
58000-507 Pulse Pick-up for Rat, diam. 7 mm
58000-508 Pulse Pick-up for Rat, diam. 8 mm
58000-509 Pulse Pick-up for Rat, diam. 9 mm
Available Tail Cuffs
58000-606 Tail Cuff for Mouse, diam. 6 mm
58000-609 Tail Cuff for Rat, diam. 9 mm
58000-611 Tail Cuff for Rat, diam. 11 mm
58000-613 Tail Cuff for Rat, diam. 13 mm
Available Holders
58000-343 Mouse Holder, 30 mm I.D.
58000-344 Rat Holder, 40 mm I.D.
58000-345 Rat Holder, 50 mm I.D.
58000-346 Rat Holder, 60 mm I.D.
58000-348 Rat Holder, 80 mm I.D.
58000-840 Mouse Heater, compl. with 6 mouse holders

Rat Heater, complete with 5 rat holders of selectable I.D.*

58000-850 Rat Scanner, complete with 5 rat holders of selectable I.D.* °
* if diameter is not specified, the 50mm size will be supplied
° pressure cuffs & pulse pick-ups are not included, and should be ordered separately
Method Papers
M. Gerold & H. Tschirky “Measurement of Blood Pressure in Unanaesthetized Rats” Arzneimittelforschung 18: 1285-287, 1968
M. Gerold & H. Fünfshilling: “Abhängigkeit der Indirekten Blutdruckmes-sung an Ratten von der Grösse der Kompressionmanchetten” Arzneimit-telforschung. 21: 2071-2074, 1971
Ugo Basile Device papers
W. R. C. Ouedraogo, L. Belemnaba, M. Nitiema, B. Kabore, S. Compaore, M. Koala, R. Semde, S. Ouedraogo, 2023, “Evaluation of acute, subacute toxicity and in vivo impact of aqueous decoction of Flemingi* fagine* Guill. & Perr. (Barker) leafy stems on NMRI mice and normotensive Wistar rats”, Journal of Drug Delivery and Therapeutics (JDDT)
L. Belemnaba, M. Nitiéma, S. Ilboudo, G. G. Ouédraogo, N. Ouédraogo, M. B. Belemlilga, S. Compaoré, S. Ouédraogo, S. Ouédraogo, 2021, “Preclinical Evaluation of the Antihypertensive Effect of an Aqueous Extract of Anogeissu* leiocarpa* (DC) Guill et Perr. Bark of Trunk in L-NAM*-Induced Hypertensive Rat”, Journal of Experimental Pharmacology
A. M. Nasr, S. Rezq, A. Shaheen, S.M. Elshazly, 2020, “Renal protective effect of nebivolo* in rat models of acute renal injury: role of sodiu* glucos* co-transporter 2”, Pharmacological Reports
A.S. Mainasara, S.A. Isa, A. Dandare, M.J. Ladan, Y. Said, S. Rabiu, 2016, “Blood pressure profile and insulin resistance in salt-induced hypertensive rats treated with camel milk”, Mediterranean Journal of Nutrition and Metabolism
H. Schirutschke, L. Gladrow, C. Norkus, S. P. Parmentier, B. Hohenstein, C. P. M. Hugo, 2014, “A New Apparatus for Standardized Rat Kidney Biopsy”, Plos One
M. Atanasova, Z. Petkova, D. Pechlivanova, P. Dragomirova, A. Blazhev, J. Tchekalarova, 2013, “Strain-dependent effects of long-term treatment with melatoni* on kaini* aci*-induced status epilepticus, oxidative stress and the expression of heat shock proteins”, Pharmacology Biochemestry and Behavior
J. Tchekalarova, D. Pechlivanova, D. Itzev, N. E. Lazarov, P. Markova, A. Stoynev, 2010, “Diurnal rhythms of spontaneous recurrent seizures and behavioral alterations of Wistar and spontaneously hypertensive rats in the kainat* model of epilepsy”, Epilepsy & Behaviour
K. D. Simeonova, K. D. Dimitrov, N. D. Danchev, 2015, “Antihypertensive Effect Of Magnesiu* Sulfat* (*ormagnesin®) And Its Combination With Furosemid* On Conscious Spontaneously Hypertensive Rats”, Journal of Biochemical and Clinical Research
V. De Gennaro Colonna, S. Fioretti, A. Rigamonti, S. Bonomo, B. Manfredi, E. Muller, F. Berti, G. Rossoni, 2006, “Angiotensin II type 1 receptor antagonism improves endothelial vasodilator function in L-NAME-induced hypertensive rats by a kini*-dependent mechanism”, Journal of Hypertension
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