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What are the main factors to consider in the context of behavioral tests for drug discovery research

Given the importance of drug discovery tests on rodents, which may determine successful translation of preclinical results into clinical settings, the choice of the right behavioral test and how to run it is especially important and well described by Hanell and Marklund (2014, https://www.frontiersin.org/articles/10.3389/fnbeh.2014.00252/full )