When rodents are exposed to inescapable and unpredictable stress, such as forced swim or inescapable foot shock, they often develop deficits in memory and learning tasks (e.g. Active Avoidance) and they often show analgesic reactions (S.I.A. Stress-Induced Analgesia).
The Ugo Basile Set-Up for Learned Helplessness is based on a sophisticated generator of unpredictable random shocks delivered to the grid floor of a rodent box where no escape is possible. Electric shocks can be randomized in terms of shock length, interval and complex trains can be programmed.