Conditioned Place Preference (CPP) Cages for Rats or Mice ^Featured

Additional Info

FEATURE	BENEFIT
Interchangeable patterned floors and walls	The two compartments differ by tactile stimulation
Walls in either compartment can be altered, by replacing the context kit	The two compartments differ by visual stimulation
High contrast with light or dark animals	Optimized for Video-Tracking
Specific models and floors for rats or mice	Designed for multiple-cage systems

Physical
External Dimensions (handles excluded)	42552 Rat Cage:      63x32x35(h)cm   42553 Mouse Cage: 35x18x29(h)cm
Internal Dimensions (of each compartment)	42552 Rat Cage:      30x30x30(h)cm   42553 Mouse Cage: 16x15x25(h)cm
Patterned Floors	4 interchangeable floors for each cage
Context Walls	2 interchangeable context kits provided with each cage (striped and checkered)
Shipping Weight	42552 Rat Cage:      22Kg 42553 Mouse Cage: 10Kg
Packing Dimensions	42552 Rat Cage:      80x46x56cm 42553 Mouse Cage: 36x55x45cm
Warranty	42552/3 is covered by a 24-month warranty

The CPP paradigm provides information on the rewarding or aversive effects of visible and tactile contextual cues associated with drugs. 

This technique has acquired great popularity in research studies involving addiction, being much easier, if compared to drug self-administration procedures. 

First, the animal is conditioned to identify one of the two compartments with the drug experience. Then the time spent in each compartments is measured; preference or
aversion to the drug-paired compartment, hence rewarding/aversive properties of drugs, can be easily deducted.

The CPP test only requires the animal to carry out a simple operation (i.e. move from one compartment to the other) to approach or avoid the drug-paired compartment; the animal is expected to spend more time in the drug-paired compartment, if the drug experience produced a positive effect.

 

 

42503	CPP BOX for RAT, complete
M-TR 230-F	Floor Drawer (2 pcs. are provided)
42503-011	Round 2mm holes, 6mm interax. (2 pcs.)
42503-012	Round 12mm holes, 16mm interax. (2 pcs.)
42503-014	Square 6x6mm holes, 9mm interax. (2 pcs.)
42503-013	Square 10x10mm holes, 12mm interax. (2 pcs.)
42552-320	Wall Context Kit for Rat Cage
42503	CPP BOX for MOUSE, complete
M-TR 238-F	Floor Drawer (2 pcs. are provided)
42503-011	Round 2mm holes, 6mm interax. (2 pcs.)
42503-012	Round 12mm holes, 16mm interax. (2 pcs.)
42503-014	Square 6x6mm holes, 9mm interax. (2 pcs.)
42503-013	Square 10x10mm holes, 12mm interax. (2 pcs.)
42553-320	Wall Context Kit for Rat Cage

Bibliography on 42552

• Baclofen Prevents Drug-Induced Reinstatement of Extinguished Nicotine-Seeking Behaviour and Nicotine Place Preference in Rodents L. Fattore et alia, Eur. European Neuropsychopharmacol. 19(7): 487-498, 2009
• Inhibition of Anandamide Hydrolysis by Cyclohexyl Carbamic Acid 3’-Carbamoyl-3-yl Ester (URB597) Reverses Abuse-Related Behavioral and Neuro-chemical Effects of Nicotine in Rats M. Scherma et alia, J. Pharmacol. and Exper. Therap.” 327:482–490, 2008

Special thanks to Prof. Paola Fadda (Department of Pharmacology, University of Cagliari, Italy) for the initial design of the boxes: her valuable comments and suggestions allowed us to keep the focus on the user needs and opinions.