Behaviour, Conditioning, Reward
Code: 40530

Active Avoidance Set-Up (Shuttle-Box) for Rats and Mice

The new model of Active Avoidance Set-Up has been designed to enable the researcher to perform a wide range of avoidance experiments, each according to a flexible schedule.

Via the TIMELINE feature, the user will be able to configure a number of different tests, according to the specific experimental needs, namely the classical shuttle-box tests in its various modes.

The Active Avoidance set-up is part of UB conditioning-cage project; you buy a single touch-screen controller, and manage all UB cages. Ask for details!

Active avoidance is a fear-motivated associative avoidance task. In this task the animal has to learn to predict the occurrence of an aversive event (shock) based on the presentation of a specific stimulus (tone), in order to avoid the aversive event by moving to a different compartment.

The measures recorded include number of avoidances (the mouse crossing to the other compartment during the warning signal), number of non-responses (the mouse failing to cross to the other compartment during the trial), response latency (latency to avoid or escape), number of intertrial responses (i.e., crossing the barrier within the intertrial interval), and serve as an index of learning and allows memory to be assessed.

Ugo Basile Active Avoidance set-up instrument basically consists of a Controller, and a Cage for either rat or mouse. The tests are conducted in a cage, divided into two sections by a partition with an intercommunicating opening at floor level.

The tilting floor ensures a simple and relaible detection mechanism to score the animal’s movement across the two compartments. The electronic unit encompasses all controls for up to 4 cages and a scrambling shocker.

Additional Info

    Part of the BEEHIVE SYSTEM the electronic unit encompasses all controls for up to 4 animal cages!
    Maximum Flexibility Configure your own Avoidance-Experiment Schedules via the timeline function
    Tilting-floor detection Reliable and precise detection of animal crossing
    Remote Control feature Makes remote service and software upgrades extremely simple!
    Great Versatility The same controller can manage different conditioning tests. Ask for details!
    Touch Screen Controller
    LCD 12” with resistive touch screen
    CPU Module Port 2 USB Port 2.0; 1 Ethernet port 10/100Mb;1 DVI port for external monitor
    Peripheral Port 4 output for Sound, Shock and  light; 1 Power supply 12V-2A
    Expansion Bus         Connection 2 RJ11 connectors
    Shock Constant current
    Shock Intensity from 0 to 3mA, in 0.1mA steps
    Shock Duration in 0.1s
    Visible Light 0-100, in steps of 5%
    Sound frequency 100-18.000Hz, in steps of 100Hz
    Operating Temperature 10° to 40°C
    Pollution Degree ≤ 2
    Number of Cages Up to 4 (with expansion boxes)

    25(d)x33(w)x5.5(h)cm (40500-001)

    57x27x30(h)cm, I.D. 48x20x22(h) (40532)

    47x18x25(h)cm, I.D. 38x9x17(h)cm (40533)


    2.7Kg (40500-001)

    5.3 (40532)  

    3.5 (40533)  

    Shipping Weight

    Rat Set-Up      13Kg

    Mouse Set-Up 12Kg

    Packing Dimensions 80x60x44cm (Control Unit & one cage)
    Warranty 40530 is covered by a 24-month warranty

    Behavioral scientists are well acquainted with avoidance methods that have been used for several decades, originally by psychologists, who were interested in animal behavior.

    These procedures were later exploited by neuroscientists, who specifically perform sys-tematic studies of the behavioral changes mainly produced by brain lesions, to define the functions of different C.N.S. sections.

    Avoidance tests were soon extended to several other areas of research such as behavior genetics, psychopharmacology and behavioral toxicology. More recently, such use has become routine in animal model studies of aging and of Alzheimer-type dementia, including the search for new drugs of potential therapeutic value, consisting of attenuation of behavioral deficits.

    40500-001 Controller with Touch Screen and 8-pole Scrambling Shocker
    40530-010 Software and activation for Active Avoidance Test
    40532 A.A. Rat Cage
    52010-323 USB Cable
    E-AU 041 USB pen-drive, including
    40530-302      Instruction Manual 
    40500-001 Controller with Touch Screen and 8-pole Scrambling Shocker
    40530-010 Software and activation for Active Avoidance Test
    40533 A.A. Mouse Cage
    52010-323 USB Cable
    E-AU 041 USB pen-drive, including
    40530-302      Instruction Manual 


    The following is an example of configuration of a 4-Cage Mouse set-up:

    1 40500-001 Controller with Touch Screen and 8-pole Scrambling Shocker
    40550-010 Software and activation
    4 40533 A.A. Mouse Cage
    3 40500-005 Expansion Box (one is required for each additional cage)

    Bibliography on 40530

    • C.I. Navarro-Francés et alia: “Influence of trait anxiety on the effects of acute stress on learning and retention of the passive avoidance task in male and female mice” Behav. Processes 105: 6-14, 2014
    • P. Borracci eta lia: “Rat Embryo Exposure to All-Trans Retinoic Acid Results in Long-Term Congitive Deficits” Eur Rev Med Pharmacol Sci 18: 28-33, 2014
    • D. Dimitrova, D. Getova: “Effects of Rivastigmine on Learning and Memory Processes in Rats Active Avoidance Test” Medicine 4.1, 2014
    • D. Cutuli et alia: “n-3 Polyunsaturated Fatty Acids Supplementation Enhances hippOcampal Functionality in Aged Mice” Front Aging Neurosci 6, 2014
    • G.N. Carmona et alia: “The Dense Core Vesicle Protein IA-2, but not IA-2β, is Required for Active Avoidance Learning” Neuroscience 269 (6): 35-42, 2014
    • A. Buzescu et alia: “The Influence of Some Psychotropic Substances on Conditioning Using an Active Avoidance Paradigm” Farmacia 62(1), 2014
    • O. Ortiz et alia: “Associative Learning and CA3–CA1 Synaptic Plasticity Are Impaired in D1R Null, Drd1a/Mice and in Hippocampal siRNA Silenced Drd1a Mice“ J.Neuroscience 30 (37): 12288-12300, 2010
    • J.I. Lemos et alia: “Involvement of the prelimbic prefrontacortex on cannabidiol-induced attenuation of contextual conditioned fear in rats“ Behav. Brain Res. 207: 05-111, 2010
    • N. Seferos et alia: “Mandibular bone density and calcium content affected by different kind of stress in mice“ J Musculoskelet Neuronal Interact. 10 (3): 231-236, 2010

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