Startle/PPI Test Multiple-cage Set-Up for Mice ^Featured

Additional Info

FEATURES	NEW ON THE 2014 VERSION!
Part of the BEEHIVE SYSTEM	the electronic unit encompasses all controls for up to 4 animal cages!
Maximum Flexibility, full event randomization	Configure your own Experimental Schedules on the touch-screen controller
Remote Control feature	Makes remote service and software upgrades extremely simple!
Great Versatility	The same controller can manage different conditioning tests. Ask for details!

Touch Screen Controller
LCD	12” with resistive touch screen
CPU Module Port	2 USB Port 2.0; 1 Ethernet port 10/100Mb;1 DVI port for external monitor
Peripheral Port	4 output for Sound, Shock and  light; 1 Power supply 12V-2A
Expansion Bus         Connection	2 RJ11 connectors
General
Sound	Pulse : in the range 100Hz-18KHz; 60-120dB
	Prepulse : 100Hz-18KHz; 60-120dB
	White-Noise : 60-80dB
Light	IR Light : 0-100% (Environment)
	Flash Light : 0-100% (20K Lux) S/R Platform)
Operating Temperature	10° to 40°C
Sound Level	Negligible
Pollution Degree	≤ 2
Number of Cages	Up to 4 (with expansion boxes)
Physical
Dimensions	25(d)x33(w)x5.5(h)cm (40500-001) 48000-320 Small Mouse Box: ID 84x34x39(h)mm 48000-320 Large Mouse Box: ID 84x39x44(h)mm
Weight	2.7Kg (40500-001)
Shipping Weight	Mouse Single-Cage Set-Up   40Kg
Packing Dimensions	82x71x57cm (wooden crate) for a Mouse Single-Cage Set-up
Warranty	48000 is covered by a 24-month warranty

In animals, including humans, the startle response is a largely unconscious defensive response to sudden or threatening stimuli, such as sudden noise or sharp movement, and is associated with negative effect. Usually the onset of the startle response is a startle reflex reaction, a brainstem reflectory reaction (reflex) that serves to protect vulnerable parts, such as the back of the neck (whole-body startle) and the eyes (eyeblink) and facilitates escape from sudden stimuli.

Prepulse Inhibition (PPI) is a neurological phenomenon in which a weaker prestimulus (prepulse) inhibits the reaction of an organism to a subsequent strong startling stimulus (pulse). The stimuli are usually acoustic, but tactile stimuli (e.g. via air puffs on the skin) and light stimuli are also used.
The reduction of the amplitude of startle reflects the ability of the nervous system to temporarily adapt to a strong sensory stimulus when a preceding weaker signal is given to warn the organism.

Deficits of prepulse inhibition, manifesting in the inability to filter out the unnecessary information, have been linked to abnormalities of sensorimotor gating, noted in patients suffering from illnesses like Schizophrenia and Alzheimer’s Disease, or under the influence of drugs, surgical manipulations, or mutations. Animal models are widely used to test hypotheses linking genetic components of various diseases with sensorimotor gating.

48153	STARTLE/PPI SYSTEM FOR MICE, single cage system
40500-001	Controller with Touch Screen and 8-pole Scrambling Shocker 48000-010 Software and activation
48005	Stimulating/Recording Platform for Mouse
48000-320	Small Mouse Box
48000-322	Large Mouse Box
48000-100	Startle link-box
46000-590	Isolation Cubicle, sound attenuation box with IR Light, loudspeaker, noiseless fan
52010-323	USB pen-drive, including
	48000-302      Instruction Manual
	MULTIPLE-CAGE SET-UP
48253	STARTLE/PPI SYSTEM FOR MICE, two-cage system
1	40500-001	Controller with Touch Screen and 8-pole Scrambling Shocker 48000-010 Software and activation
2	48005	Stimulating/Recording Platform for Mouse
2	48000-320	Small Mouse Box
2	48000-322	Large Mouse Box
1	48000-100	Startle link-box
2	46000-590	Isolation Cubicle, sound attenuation box with IR Light, loudspeaker, noiseless fan
1	52010-323	USB pen-drive, including
		48000-302      Instruction Manual
48453	STARTLE/PPI SYSTEM FOR MICE, four-cage system
1	40500-001	Controller with Touch Screen and 8-pole Scrambling Shocker 48000-010 Software and activation
4	48005	Stimulating/Recording Platform for Mouse
4	48000-320	Small Mouse Box
4	48000-322	Large Mouse Box
1	48000-100	Startle link-box
4	46000-590	Isolation Cubicle, sound attenuation box with IR Light, loudspeaker, noiseless fan
1	52010-323	USB pen-drive, including
		48000-302      Instruction Manual

• M. Koch: “The Neurobiology of Startle” Prog Neuro­biol. 59(2):107-28, 1999
• D. Braff et alia: “Human Studies of Prepulse Inhibition of Startle: Normal Subjects, Patient Groups, and Phar­macological Studies” Psychopharmacology 156(2): 234-258., 2001
• H.S. Hoffman et al.: “Startle Reaction: Modification By Background Acoustic Stimulation” Science 141: 928-30, 1963
• R.R. Marsh et alia: “The Role of Small Changes in the Acoustic Environment in Modifying the Startle Reflex” J Exp Psychol Anim Behav Process, 1(3): 1975