Analyse simplifiée de la démarche des souris .
Le système d'analyse de la démarche GA.I.T de Ugo Basile est un système de paillasse entièrement automatisé de nouvelle génération, conçu pour détecter les modifications de la foulée des rongeurs avec une facilité d'utilisation inégalée et une précision de 100 % dans la détection des pattes. Il est alimenté par des algorithmes d'IA supervisés propriétaires et identifie des changements subtils liés au troubles moteurs, à l'âge ou à la douleur, que les systèmes actuellement sur le marché peuvent manquer ou demander des corrections manuelles importantes.
Le plus grand défi aujourd'hui dans l'analyse automatisée de la démarche est l'identification correcte de chaque patte pour calculer automatiquement tous les paramètres sans que le scientifique ait besoin de corriger manuellement toute erreur d'identification avant de lancer l'analyse.
La méthode développée par Ugo Basile ne repose pas sur une technologie de contraste vidéo, mais sur une intelligence artificielle supervisée ; C'est une grande avancée pour obtenir une identification de pattes pratiquement sans erreurs. Le logiciel écarte le contact du ventre, les interférences de la queue, les déplacements irréguliers ou d'autres types d'artefacts, et offre une résolution à la phalange prés, distinguant le centroïde de la paume et les phalanges même dans des empreintes complexes.
L'analyse des données affichées est automatiquement mise à jour après chaque passage, puis est enregistrée et disponible sous forme de fichier CSV à ouvrir dans MS Excel.
Locomotion is a complex behavior involving the integration of musculoskeletal, neurological and sensory systems to produce coordinated movement. Because of this, gait is a sensitive marker of pain and motor dysfunction, widely used in motor coordination and motor function models, in neurodegenerative models and injury in general, arthritis, pain and aging (Clark et al., 2019; Sayed-Zahid et al., 2019).
Early approaches to rodent gait analysis, such as inked footprints on paper, provide only coarse information on stride length and paw placement. No temporal parameter (e.g. duty cycle) is available with non-automated systems. While still used for basic screening, these manual methods lack the resolution and objectivity required to detect subtle or early motor deficits. Rodents, as quadrupeds and prey animals, often mask signs of pain or impairment (Mogil, 2015). Their ability to shift weight between limbs (e.g., compensating for hindlimb injury by loading the forelimbs) can further obscure deficits detectable in bipedal species (Saunders et al., 2017).
To overcome these challenges, automated gait analysis systems have become essential in neuroscience, pharmacology and toxicology. These tools offer high-resolution, multi-parameter assessments, such as stance duration, stride variability, and interlimb coordination, captured in a naturalistic, unforced walking environment.
Traditional Gait Analysis system available in the market still show important limitations when it comes to analysis runs outcomes. The innovative Gait Analysis by Ugo Basile is a fully automated table-top system designed to detect gait alterations in rodent models with unmatched ease and accuracy, guaranteeing exact identification of paws, paw digits and other relevant body parts (e.g. head, animal centroid, tail).
The system is powered by proprietary A.I. algorithms that identify even the most subtle gait changes that traditional tools might miss or misidentify. The end result is a huge time-saving and accuracy because no manual paw identification or correction through frame-by-frame manual revision is needed.
The mouse is moving freely starting from a transparent box to another one to favour back and forth runs, also thanks to the length and width of the corridor designed for mice, differently than other systems designed for rats also.
Once the desired number of comparable runs (i.e. similar speed) has been reached the software will automatically calculate the desired parameters and prompt the next animal.
The corridor floor is made of high-quality glass resistant to scratches and easy to clean. Green LEDs on the side of the corridor provide the frustrated total internal reflection (fTIR) effect, which enhances shapes, contact surfaces and pressure, plus all the other temporal and spatial parameters scientists are interested investigating.
The footprints appear bright green regardless of the mouse fur color (Hamers et al. 2001) and give complete flexibility, enabling step dynamics and semi-quantitative assessment of paw pressure (key in Pain Research and not only).
Two sliding cages are placed on each side of the corridor, each with its own door. They can be easily attached or removed, allowing smooth, stress-free animal handling.
A high frame rate camera is controlled by the software, which handles also background removal (e.g. feces or other artifacts) and detects valid runs automatically in real-time.
The results are saved in Excel format directly on the PC.
UB Gait Analysis is a complete plug-and-play package, including:
Its compact design and ease of use make it suitable for any lab bench, even in space-constrained environments.
In addition to the one-year Regular Warranty and in addition to the one-year product registration extended warranty, Ugo Basile offers an Optional Extended Warranty that extends the warranty period for the product for additional one or two years called “UB Care12”/“UB Care24”. Customers may purchase the “UB Care” at the maximum of 3 months after buying. For more detailed information, please contact your local representatives.
Thermal Conditioned Cabinet is an essential accessory for your TGR setup. It ensures optimal and stable environmental temperature from 0° up to 70° C (32° up to 158°F), improving test reliability and operator comfort. It holds up to two TGR units and provides insulation from light and noise, with built-in air suction and full connectivity to ANY-maze.
Thermal Conditioned Cabinet is an essential accessory for your TGR setup. It ensures optimal and stable environmental temperature from 0° up to 70° C (32° up to 158°F), improving test reliability and operator comfort. It holds up to two TGR units and provides insulation from light and noise, with built-in air suction and full connectivity to ANY-maze.
