Pain and inflammation

37360 - Tail-Flick Unit

Tail-Flick Unit Tail-Flick Unit

The Ugo Basile Tail Flick was designed to measure accurately the nociceptive threshold to infrared heat stimulus on the rat or mouse tail.

The operator starts the stimulus: when the animal feels pain and flicks its tail, a sensor detects it, stops the timer and switches off the bulb. The reaction time of the animal is thus determined nd automatically recorded.

The Tail Flick basically consists of an I.R. source, whose radiant energy of adjustable intensity is focused on the animal tail by an embodied parabolic mirror.

The rat is held by the operator on the instrument unobstructed upper panel in such a way that its tail, placed over a flush mounted window, receives the I.R. energy. The instrument can be conveniently used to stimulate the mouse tail; when requeired, mouse holders are available as optional.

Latency time & Intensity are automatically exported to a memory stick, USB, or serial port. USB Stick & Software included!

    FEATUREBENEFIT
    Tail-flick is scored automatically, by a fiber optic Precise score, free of human variability
    USB memory key and software are included Works as a stand-alone or connected to the PC
    No protruding elements and unobstructed surface Work confortably and get excellent reproducibility
       
    Operation
    Power Requirement Universal mains 85-264 VAC, 50-60Hz
    Commands                   via soft-buttons
    Read-out multifunction graphic display
    Print-out Via optional thermal MiniPrinter or panel-mount printer
    Starting via pedal switch. Additional key on the Controller  
    I.R. Intensity Adjustable in the interval 01-99 (in one digit steps)
    Latency Time displayed on the graphic display, in 0.1s steps
    Connection to PC via USB
    Data Portability to PC Via USB pen-drive provided
    Calibration Via appropriate I.R. Radiometer
    Operating Temperature 10° to 40° C
    Sound Level negligible
    Physical
    Total Weight 4Kg
    Shipping Weight 5.8Kg approx.
    Dimensions 43x22x10 cm (assembled)
    Packing Dimensions 45x34x26cm
    Warranty Tail Flick Unit is covered by a 24-month warranty.

     

     

     

     

     

     

     

     

     

    PHYSICAL DIMENSIONS  
    Dimensions: 43x22x10cm
    Weight: 4.0Kg
    Shipping Weight: 5.8Kg approx
    Packing dimensions: 45x34x26cm

     

     

     

     

     

     

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    The Tail Flick Unit basically consists of an I.R. source, whose radiant energy of adjusta-ble intensity is focused by an embodied parabolic mirror on the rat tail.
    The rat is held by the operator on the instrument unobstructed upper panelin such a way that its tail, placed over a flush mounted window, receives the I.R. energy.
    The operator starts the stimulus and the related reaction-time counter by the pedal switch or by function key located on the front panel.
    When the rat feels pain and flicks its tail, a sensor detects it, stops the reaction-time counter and switches off the bulb. The reaction time of the animal is thus automatically determined to the nearest 0.1 second.

     

    37360 Tail Flick Unit, standard package, including:
    37215-303 Pedal Switch
    E-AU 041 Memory Key, including the following:

    37370-302      Instruction Manual

    52050-10        CUB Data Acquisition Software Package

    52010-323 USB cable
    E-HR 002 Spare I.R. Bulb (Halogen "Bellaphot", Mod. 64607 OSRAM, 8V-50W)
    E-US 063-1 Battery Snaphat type M4T32-BRI2SH1
    OPTIONAL
    37360-325 Mouse Holder (25mm I.D.)
    37360-330 Mouse Holder (30mm I.D.)
    37300 Heat-Flux I.R. Radiometer (see also paragraph 9.1)
    57145 MiniPrinter (see also paragraph 3.2 and 12.3)

    See Additional Bibliography

     

    • T.O. Lilius et alia: "The Mineralocorticoid Receptor Antagonist Spironolactone Enhances Morphine AntinociceptionEur. J. of Pain online view, 201
    • J.W. Little et alia: “Spinal Mitochondrial-Derived Peroxynitrite Enhances Neuroimmune Activation During Morphine Hyperalgesia and Antinociceptive TolerancePain 154 (7): 978-986, 2013
    • P.J. McLaughlin et alia: “Behavioral Effects of the Novel Potent Cannabinoid CB1 Agonist AM 4054Pharmacology Biochemistry and Behavior 109: 16-22, 2013
    • T.A. Kosten et alia: “A Morphine Conjugate Vaccine Attenuates the Behavioral Effects of Morphine in RatsProgr. in Neuro-Psychopharmacol. and Biol. Psychiatry 45: 223–229, 2013
    • T.C. Chen et alia: “Spontaneous inflammatory Pain Model From a Mouse Line With N-ethyl-N-nitrosourea MutagenesisJ. Biomed. Science 19 (55): 2–15, 2012 
    • J. Walsh et alia: “Disruption of Thermal Nociceptive Behaviour in Mice Mutant for the Schizophrenia-Associated Genes NRG1, COMT and DISC1Brain Res. 1348: 114-119, 2012 
    • K. Guillemyn et alia: “In vivo Antinociception of Potent mu Opioid Agonist Tetrapeptide Analogues and Comparison with a Compact Opioid Agonist-neurokin 1 Receptor Antagonist ChimeraMolecular Brain 5 (4): 2-11, 2012 
    • A.J. Morrison et alia: “Design, Synthesis, and Structure–Activity Relationships of indole-3-heterocycles as Agonists of the CB1 ReceptorBioorganic & Medicinal Chemistry Letters 21: 506-509, 2011  
    • M. Spetea et alia: “In vitro and in vivo Pharmacological Profile of the 5-benzyl Analogue of 14-methoxymetopon, a Novel μ Opioid Analgesic with Reduced Propensity to Alter Motor FunctionEur. J. Pharmac. Sciences 41: 125-135, 2010 
    • C.A. Boehm et alia: “Midazolam Enhances the Analgesic Properties of Dexmedetomidine in the RatVet. Anaesthesia and Analgesia 37 (6): 550-556, 2010  
    • M.A. Philips et alia: “Myg1-Deficient Mice Display Alterations in Stress-Induced Responses and Reduction of Sex-Dependent Behavioural DifferencesBehav. Brain Res. 207: 182-195, 2010
    • C. Dawson et alia: “ Dexmedetomidine Enhances Analgesic Action of Nitrous Oxide” Anesthesiology 100 (4): 894−904, 2004
    • P. Tolu et alia: “ Effects of Long-Term Acetyl-L-carnitine Administation in Rats: I. Increased Dopamine Output in Mesocorticolimbic Areas and Protection Toward Acute Stress Exposure” Neuropsychopharmacol. 27 (3): 410-420, 2002
    • R. Nadeson et alia: “ Potentiation by Ketamine of Fentanyl Antinociception. I. An Experimental Study in Rats Showing that Ketamine Administered by Non-Spinal Routes Targets Spinal Cord Antinociceptive Systems” Br. J. Anaesthesia 88 (5): 685−691, 2002
    • L. Jasmin et alia: “ The NK1 Receptor mediates Both the Hyperalgesia and the Resistance to Morphine in Mice Lacking Noradrenaline” PNAS 99 (2): 1029−1034, 2002
    • G.L. Fraser et alia: “ Antihyperalgesic Effects of Opioid Agonists in a Rat Model of Chronic Inflammation” Br. J. Pharmacol. 129: 1668−1672, 2000
    • M. Xu et alia: “ Effects of Radolmidine, a Novel α2- Adrenergic Agonist Compared with Dexmedetomidine in Different Pain Models in the Rat” Anesthesiology 93 (2): 473−481, 2000
    • A. Köster et alia: “Targeted Disruption of the Orphanin Fq/Nociceptin Gene Increases Stress Susceptibility and Impairs Stress Adaptation In Mice” Neurobiology 96 (18): 10444-10449, 1999
    • I. Sora et alia: “Opiate Receptor Knockout Mice Define µ Receptor Roles in Endogenous Nociceptive Responses and Morphine-Induced Analgesia” Neurobiology 94: 1544-1549, 1997C.T. Dourish et alia: "The Selective CCK-B Receptor Antagonist L-365,260 Enhances Morphine Analgesia and Prevents Morphine Tolerance in the Rat" Europ. J. Pharmacol. 176: 35-44, 1990
    • P.W. Nance & J. Sawinok: "Substance P-Induced Long-Term Blockade of Spinal Adrenergic Analgesia: Reversal by Morphine and Naloxone" J. Pharmacol. Exp. Therap. Vol. 240, No. 3: 972-977, 1987
     
     

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