Behaviour, Conditioning, Reward

40550 - Passive Avoidance - Step through - New Model

Passive Avoidance - Step through Passive Avoidance - Step through

The Passive Avoidance Set-Up (step-trough method) by Ugo Basile, is an efficient and reliable insturument fo the classic Passive Avoidance Test. 

Multiple configurations can be controlled by the NEW  electronic with touch-screen, which encompsses a precision 8-pole shocker.

The P.A. set-up is part of UB conditioning-cage project; you buy a single touch-screen controller, and manage all UB cages. Ask for details!

 

Passive Avoidance Test is used to assess memory function based on the association formed between a specific environmental context, which the animal learns to avoid, and an aversive stimulus, represented by a mild foot shock. The tests are conducted in a two-compartment apparatus, where one is dimly lit and preferable to a rodent, and the other is brightly lit.

Ugo Basile Passive Avoidance set-up instrument basically consists of a Controller, and a Cage divided into two compartments by a partition which embodies a sliding door. The tilting floor ensures a simple and relaible detection mechanism to score the animal’s movement across the two compartments.The 40500-001 Programming/Recording Unit, encompasses all controls, incorporates a constant-current high precision 8-pole shocker, and manages data acquisition: data are stored insite the unit and can be downloaded via the USB key provided as standard, for further processing via Excel, Access, etc.

The Unit, which incorporates a 12” touch-screen, manages both Passive and Active Avoidance Tests. Up to 4 cages can be connected to the same Controller. If more than one cage is connected, an expansion box 40500-005 is required for each additional cage. 

Remote Control feature will make remote service and software upgrades extremely simple!

    FEATURES BENEFITS
    Part of the BEEHIVE SYSTEM the electronic unit encompasses all controls for up to 4 animal cages!
    Tilt-floor detection mechanism Reliable and precise detection of animal crossing
    No stepping motor! Silent and automated sliding door to divide the two compartments
    Remote Control feature Makes remote service and software upgrades extremely simple!
    Great Versatility The same controller can manage different conditioning tests. Ask for details!
    Touch Screen Controller
    LCD 12” with resistive touch screen
    CPU Module Port 2 USB Port 2.0; 1 Ethernet port 10/100Mb;1 DVI port for external monitor
    Peripheral Port 4 output for Sound, Shock and  light; 1 Power supply 12V-2A
    Expansion Bus         Connection 2 RJ11 connectors
    General
    Latency Time 5-digit Read-Out, 0.1s steps
    Door Delay 0-99s, in steps of 1s
    Shock Duration 0.1-9.9s, in steps of 0.1s
    Shock Intensity 0.1-9.9mA, in steps of 0.1mA
    CutOff Time 1-600s, in steps of 1s
    Visible Light Variable from 0 to 1800 Lux
    Operating Temperature 10° to 40°C
    Sound Level Negligible
    Pollution Degree ≤ 2
    Number of Cages Up to 4 (with expansion boxes)
    Physical
    Dimensions

    25(d)x33(w)x5.5(h)cm (40500-001)

    57x27x30(h)cm, I.D. 48x20x22(h)cm (40552) 47x18x25(h)cm, I.D. 38x9x17(h)cm (40553)

    Weight

    2.7Kg (40500-001)

    5.3Kg (40552)

    3.4Kg (40553)

    Shipping Weight

    4Kg (40500-001)

    9Kg (40552)

    5.8Kg (40553)

    Packing Dimensions 80x60x44cm (Control Unit & one cage)
    Warranty 40550 is covered by a 24-month warranty

    Behavioral scientists are well acquainted with passive avoidance methods that have been used for several decades, originally by psychologists, who were interested in animal behavior.

    These procedures were later exploited by neuroscientists, who specifically perform sys-tematic studies of the behavioral changes mainly produced by brain lesions, to define the functions of different C.N.S. sections.

    The Passive Avoidance was soon extended to several other areas of research such as behavior genetics, psychopharmacology and behavioral toxicology. More recently, such use has become routine in animal model studies of aging and of Alzheimer-type demen-tia, including the search for new drugs of potential therapeutic value, consisting of atten-uation of behavioral deficits.

    The Passive Avoidance task is a one trial fear-motivated avoidance task, classically used to assess short-term or long-term memory on small laboratory animals (rodents).

    PASSIVE AVOIDANCE SET-UP, RAT
    40500-001 Controller with Touch Screen and 8-pole Scrambling Shocker
    40550-010 Software and activation for Passive Avoidance Test
    40552 P.A. Rat Cage
    52010-323 USB Cable
    E-AU 041 USB pen-drive, including
    40550-302      Instruction Manual  
    PASSIVE AVOIDANCE SET-UP, MOUSE
    40500-001 Controller with Touch Screen and 8-pole Scrambling Shocker
    40550-010 Software and activation for Passive Avoidance Test
    40553 P.A. Mouse Cage
    52010-323 USB Cable
    E-AU 041 USB pen-drive, including
    40550-302      Instruction Manual  

    MULTIPLE-CAGE SET-UP

    The following is an example of configuration of a 4-Cage Mouse set-up:

    1 40500-001 Controller with Touch Screen and 8-pole Scrambling Shocker
    40550-010 Software and activation
    4 40553 P.A. Mouse Cage
    3 40500-005 Expansion Box (one is required for each additional cage)

    See Additional Bibliography

     

    • C.I. Navarro-Francés et alia: “Influence of trait anxiety on the effects of acute stress on learning and retention of the passive avoidance task in male and female miceBehav. Processes 105: 6-14, 2014
    • L. Zvejniece et alia: “The cognition-enhancing activity of E1R, a novel positive allosteric modulator of sigma-1 receptorsBr. J. Pharmacol. 171(3): 761-771, 2014
    • P. Borracci et alia: “Rat embryo exposure to all-trans retinoic acid results in long-term cognitive deficitsEur. Rev. Med. Pharmacol. Sci 18:28-33, 2014
    • C. Nasuti et alia: “Neonatal exposure to permethrin pesticide causes lifelong fear and spatial learning deficits and alters hippocampal morphology of synapsesJ. Neurodevelopmental Disorders 6-7: 1866-1955, 2014
    • R.W. Flint et alia: “NMDA Receptor Antagonism with MK-801 Impairs Consolidation and Reconsolidation of Passive Avoidance Conditioning in Adolescent Rats: Evidence for a State Dependent Reconsolidation EffectNeurobiology of Learning and Memory 101: 114-119, 2013
    • G. Telegdy et alia: “The Action of Kisspeptin-13 on Passive Avoidance Learning in Mice. Involvement of TransmittersBehav. Brain Res. 243: 300-305, 2013
    • V. Capurro et alia: “Pharmacological Characterization of Memoquin, a Multi-Target Compound for the Treatment of Alzheimer’s DiseasePLoS ONE 8(2): e56870, 2013
    • J. Michaud et alia: “Hematopoietic MyD88-Adaptor Pro­tein Acts as a Natural Defense Mechanism for Cognitive Deficits in Alzheimer’s DiseaseStem Cell Reviews and Reports 8 (3): 898-904, 2012
    • E.R.A.Y. Detrait et alia: “The inhibitory avoidance test op­timized for discovery of cognitive enhancersBehavior Research Methods 41 (3): 805-811, 2009

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