Pain and inflammation

38450 - e-VF Electronic Von Frey

e-VF e-VF

The UB Electronic Von Frey of original design, for automatic assessment of Hypersensitivity and Allodynia in rats and mice, automatically records the animal response to user-controlled application of force rate.

A touch stimulator transducer is mounted on a Perspex handle, so that routine procedures may be employed to examine and test the animal skin sensitivity. A prism of original design is of great help to localize the aimed stimulation area

The completion of each test may be indicated either by the sudden release of the paw or by pressing the external foot-pedal. The display then gives the operator a summary of the results of the test (i.e. force and time corresponding to the animal response).

The rate of application of the force is set by the operator and the e-VF includes software tools that help the operator in consistently applying the force at the desired rate.

The device includes as standard both a control unit with internal memory and the NEW DCA software for signal monitoring, data transfer and analysis. The results of several hundred tests may be stored in the e-VF, be browsed on the control unit and/or trasferred to a PC in proprietary, Excel (.xls) or text (.txt) format, to be managed by most statistical analysis packages available on the market.

The instrument includes:

  • an electronic unit
  • a touch stimulator with a viewing prism of original design
  • the software

The 37450-278 Base assembly for plantar stimulation, or with the self-supporting perforated platforms 37450-045 / 37450-085 (see picture), can be purchased separately to complete the set-up, when the stimulation target is the rodent plantar surface. 

     

    Resolution: 0.1g

    DCA Software included - NEW 2014 Release

    Maximum Applicable Force: 1000g

    Location of the target via the original prism-design

    User-controlled application of force rate

    Automatic recording of animal response

    * Speaking about force, although the sensor can detect forces from 0 to 1000g, it is reasonable to set the device lower limit to 5g, given by difficulty, even for the most skilled user, to apply forces below this threshold.

    Operation
    Commands                   via soft-buttons
    Read-out multifunction graphic display
    Starting via keys on the Controller front panel
    Force Range up to 1000 grams (maximum force can be preset)
    Force increasing rate monitored via the Ratemeter on the electronic unit, or via the slope function on the PC
    Latency Time read-out on the graphic display, in 0.1 s steps
    Connection to PC via USB cable (A to mini-B)
    Power Requirement either battery operated, or via USB cable connected to PC or universal converter  (85-264 VAC, 50-60Hz)
    Operating Temperature 10° to 40° C
    Sound Level negligible
    Pollution Degree ≤ 2
    Physical
    Total Weight 0.8 Kg
    Shipping Weight 2.7 Kg approx.
    Packing Dimensions 46 x 38 x 27  cm
    Warranty
    38450 is covered by a 24-month warranty
     

     

     

    Impaired cutaneous sensation is usually first manife­sted in a loss of light touch detection. The Electronic Von Frey was developed to quantify light touch in the laboratory animal.

    The classic instrument for test of touch sensitivity is the Von Frey hair or, more specifically, the Semmes- Weinstein set of Von Frey Hairs, i.e., 20 monofilaments in a linear scale of physical force.

    The hair is pressed against the skin, the force applied increases with incre­asing hand pressure, until the hair bends; once the hair is bent, increasing hand approach causes further bend, but negligible additional force on the skin. In this way, a given filament always applies the same force, not subject to variation by the energy of the operator.

    The Semmes-Weinstein set can be used on rodents (which respond to light touch of the paw, if they feel it, by a paw withdrawal reflex). However, the involved proce­dure is tedious and time-consuming because several stimulations must be performed for a single test (i.e. a different filament for each force level).

    Compared to the classic Von Frey Hairs, the Electronic Von Frey device (e-VF) has the advantage of ensuring a continuous force application along the whole force capacity of the sensor (i.e. 1-1000 gf), by using a rigid metal tip, and the capability to record the animal response automatically.

    Moreover, the metal tip used in the e-VF is the same as the one used in the classic Ugo Basile Dy­namic Plantar Aesthesiometer (PN 37450), allowing consistent comparison of results among the two instru­ments.

    38450 EVF Electronic Von Frey consisting of:
    38450-001 Electronic Unit               
    38450-004 Touch Stimulator Transducer, with handle,  including
    38450-310  Glass Prism
    38450-330  Filament, with magnetic fixing
    38450-323 External trigger switch (foot pedal)
    52010-325 USB Lead
    E-AU 059 Universal Power Supply
    E-AU 041 USB pen-drive, including
    38450-302      Instruction Manual  
    DCA              Software  

    Optional

    37450-278 Base assembly for plantar stimulation, including support with columns, perforated metal sheet and multiple-configuration animal-enclosure, from 3 to 12 spaces.
    37450-005 Large Perforated Metal Sheet
    37450-045 Large Perforated Metal Sheet, with 4 legs, 40cm height (animal enclosure 37000-006 is not included and should be ordered separately)
    37450-085 Large Perforated Metal Sheet, with 4 legs, 80cm height (animal enclosure 37000-006 is not included and should be ordered separately)

     

     

     

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