Douleur et inflammation
Code: 38500

Algomètre PAM (Pressure Application Meter)

L'université d'Edimbourg a mis au point l'algomètre PAM. Ugo basile a été chargé d'en développer une version commercialisable en 2007. Il a été dessiné et validé spécifiquement pour la recherche sur l'arthrose afin de pouvoir appliquer une force connue au niveau des articulations des modèles murins (genoux hanches). Le PAM a trouvé aussi son utilité dans les douleurs lombaires et pour des applications locales calibrées et synchronisées en électrophysiologie in vivo.

 

The PAM device can also be used to measure mechanical sensitivity in mice and rats paw, by using a specific Paw Pressure Transducer (optional).

The PAM device t applies a quantifiable force for direct stimulation of the joint and for automatic readout of the response.

The operator simply wears a special force sensor on his or her thumb and the peak amplifier measures the force which elicits the animal response (normally, limb withdrawal).

Each PAM device comes standard with two force sensors, which have been specially designed to apply force to rat and mouse joints.

The device includes as standard both a control unit with internal memory and the NEW DCA software for signal monitoring, data transfer and analysis. Once saved, data can be browsed on the control unit and/or trasferred to a PC in proprietary, Excel (.xls) or text (.txt) format, to be managed by most statistical analysis packages available on the market.


Informations supplémentaires

    FEATUREBENEFIT
    The force is applied directly to the joint Direct measurent of evoked pain
    Specifically designed for arthritis research The applicators are shaped for rodents knee and ankle
    Paw pressure transducer is an optional PAM can also be used as a hand-held Randall-Selitto device
       
    • Resolution: 0.1g
    • Maximum applicable Force: 1500g
    • Weight 1.4Kg
    • Shipping Weight 2.7Kg
    • Packing 46x38x27cm

    Arthritis is associated with chronic, debilitating pain in the joints. Current metrics of arthritic pain in animal models are indirect, by scoring the level of motor activity or the animal weight distribution (Barton et al. 2007); while correlating well with the level of joint pain, their metric is a composite picture of complex pain responses, and provides little direct information about local stimulation and locally-evoked responses.

    The quantification of localized joint hypersensitivity is not common in animal experiments; in this sense the PAM device represents a step forward toward multifactorial measurement of pain-related behavior in animal research; the PAM is the first instrument designed specifically to apply force to the joint and automatically detect the animal response.

    38500 PAM, standard package, including the following components:

    38500-001 Electronic Unit

    38500-002 Large Joint Transducer

    38500-003 Small Joint Transducer

    38500-011 DCA Software (on USB Key)

    38500-302 Instruction Manual (on USB Key)

    38500-303 Pedal Switch

    All components lodged in a dedicated plastic case

    Options

    38500-006 Paw Transducer

    38550 PAM, high-pressure model for large animals

    Physical

    Weight 1.4 Kg (in the plastic case)

    Shipping weight 2.7 Kg

    Packing 46x38x27cm

    Shipping Weight 27.50 Kg approx

    • {module Bibliography on 38500}

    Acknowledgements:

    The PAM device was invented and validated in the University of Edinburgh by the team of Prof. Daniel McQueen, Susan Bond and colleagues and Dr. Harry Brash, who built the first prototypes.



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