Nouveautes
mercredi, 06 février 2019 16:32

Key role of gut microbiota in anhedonia-like phenotype in rodents with neuropathic pain. Publication récente

Paper Paper naturetranslational psychiatry

Chun Yang, Xi Fang et ses collègues à Tongji Medical College, Wuhan, China, Soochow University, Changzhou, Chine, et Chiba University, Chiba, Japon, Ont récemment publié des résulats de recherche intéréssants dans le journal TRANSLATIONAL PSYCHIATRY,  à propos du rôle du microbiote intestinale dans les phénotypes de type anhédonique sur des rongeurs atteints de douleurs neuropathiques.

Les résultats de tests à l'allodynie mécanique ont été obtenu avec l'instrument Von Frey électronique de UGO BASILE e-vf Electronic VonFrey eVF.

38450 002 with glass prism 654x768  DSC 0100 1024x679

Extrait

“Patients with chronic neuropathic pain frequently suffer from symptoms of anhedonia, which is a core symptom of depression. Accumulating studies suggest that gut microbiota may play a role in depression via gut–microbiota–brain axis. However, it is unknown whether gut microbiota plays a role in neuropathic pain-associated anhedonia. Here, we used a rat model of spared nerve injury (SNI). Hierarchical cluster analysis of sucrose preference test (SPT) results was used to classify the SNI rats with or without anhedonia-like phenotype. The 16S ribosomal RNA sequencing analysis showed abnormal composition of gut microbiota in the anhedonia susceptible compared to sham-operated rats and resilient rats. Furthermore, antibiotics-treated mice showed pain as well as depression-like and anhedonia-like phenotypes, suggesting a role of gut microbiota in these abnormal behaviors. Transplantation of fecal microbiota from anhedonia susceptible rats into antibiotics-treated pseudo-germ-free mice significantly exaggerated pain and depression-like phenotypes, including anhedonia. In contrast, transplantation of fecal microbiota from resilient rats into antibiotics-treated pseudo-germ-free mice significantly improved pain and depression-like phenotypes, including anhedonia. In conclusion, this study suggests that abnormal composition of gut microbiota may contribute to anhedonia susceptibility post SNI surgery, and that gut microbiota also plays a role in the pain as well as depression-like phenotypes. Interestingly, fecal microbiota transplantation from SNI rats with or without anhedonia can alter pain, depression-like and anhedonia-like phenotypes in the pseudo-germ-free mice. Therefore, it is likely that gut microbiota plays a key role in the pain as well as depression-like phenotypes including anhedonia in rodents with neuropathic pain.

Accés à l apublication complète ici: https://www.nature.com/articles/s41398-019-0379-8

paper evf

 

 

Dernière modification le vendredi, 29 mars 2019 12:09

P.IVA, C.F. e n. Registro Imprese di Varese 02728350121 - n. REA VA-281472 - Cap. soc. i.v. € 165.000,00