Coordination motrice test d'aggrippement activite

47750 - Rat RotaRod NG Featured

Rat RotaRod NG Rat RotaRod NG

The “Rota-Rod” technique is essential in screening drugs potentially active, or having side effects, on motor coordination. Ugo Basile designed the original RotaRod, the first industrial RotaRod almost 50 years ago, based on the 1957 paper by N.W Dunham and T.S Miya. The 47750 RotaRod NG (Next Generation), is an evolution of the original model and the result of many years of research in cooperation with the latest development in behavioral and pharmacological research. 

Since then, our models have been cited in thousands of scientific papers. The name we coined soon became so popular, now everybody knows this devuce as RotaRod!

What's new in the NG model:

Physically similar to the previous versions, it offers the same reliability, matched with innovative technology! The new model features stainless-steel trip-boxes to facilitate cleaning and confine the animals when they fall off the rod.

The Rat RotaRod consists of four 6cm diam. cylinders, which are suitably machined to provide grip. Five 49cm diam. dividers make for four lanes, each 8.7cm wide, enabling four rats to be on the rotor simultaneously. The height to fall is 30cm.

A brand new, user friendly software, is included as standard; via the new software, the operator can easily organize the experiment on her/his PC, and upload it to the Rota-Rod via the USB key. The software automatically classifies the data, combining configuration settings with test results; the user can add information, before or after the test. Results appear in a tree-like structure, where columns can be dragged and dropped to customize the layout. Configurations and data are exported as Text, Excel or Pdf reports and can be saved to cloud via DropBox, OneDrive, GoogleDrive.

The experiment can be set and results can be monitored, also via the 4”3 touch-screen.

Remote diagnosis and internet access are provided.

The 47750 combines the same functionality of the previous version, now considered the standard, with additional new features: surprisingly silent operation, much easier experimental organization and data management.

NEXT GENERATION ROTAROD: SAME RELIABILITY, INNOVATIVE TECHNOLOGY!

 

    FEATURE

    BENEFIT

    Speed adjustable in the range
    5-80 RPM, in steps of 1 RPM                 
    Useful in a variety of tests
    Constant speed, ramp (accelerat­ing), multi-step ramp (NEW!)
    Extreme versatility
    New trip boxes
    To enclose the animals, stainless-steel to ease sterilization
    Embedded USB memory stick
    Does not required connection to PC (software included) to store and transfer data
    Brand new Software
    user friendly, included as stan­dard, enables setting up the experiment and managing the results from PC or 4"3 touch-screen
    General
    Commands 4”3 touch-screen (resistive)
    Read-out on the touch-screen
    Power Requirement Universal input 85-264 VAC, 50-60Hz, 40W max.
    Sound Level < 60 dB (A)
    Operating Temperature 10° to 40° C
    Operation
    Speed adjustable in the range 5-80 RPM, in steps of 1 RPM
    Mode constant, ramp (accelerating), multi-step ramp (NEW!)
    Rotation forward, reverse, rocking
    Rotor Start/Stop on the touch-screen
    Counting Start /Stop each section via its trip box
    Trip-Box stainless-steel to ease sterilization
    Drive forward, reverse, rocking
    Data Acquisition via X-PAD software, provided
    Data Portability by USB flash drive
    TTL Output for lane status, rotation and speed
    Data exported to Text, Excel or Pdf, or saved to cloud to DropBox, OneDrive, GoogleDrive
    Configurations exported to Text, Excel or Pdf, or saved to cloud to DropBox, OneDrive, GoogleDrive
    Physical
    Total Weight 15Kg
    Shipping Weight 21Kg approx.
    Dimensions 55(w)x46(d)x57(h)cm
    Packing Dimensions 76x60x80cm
    Warranty 47750 is covered by a 24-month warranty

    The “Rota-Rod” technique has been originated by a 1957 paper of N.W. Dunham and T.S. Miya (see paragraph 9.1-Method Papers) and has proved to be of great value in research involving screening of drugs which are potentially active on motor co-ordination.

    Ugo Basile designed the first industrial RotaRod in the 1960s. The name we coined soon became so popular, now everybody knows this instrument as RotaRod!
    The Rota-Rod is the reference test to screen drugs potentially active, or having side effects, on motor coordination.

    When a rat falls off its cylinder section onto the trip-box below, the plate boxes and the corresponding magnetic switch is activated, thereby recording the animal endurance time in seconds.

    The display shows the actual angular speed (RPM). At the end of a run, the display shows for each animal the running time, the rotation mode and the rotation speed at the time the animal fell off, combined with information preset by the user.

    47750 Rat RotaRod NG, complete with standard accessories
    47750-320 Stainless-Steel Trip-Box (4 are provided with standard package)
    E-AU 041

    USB pen drive, including:

    47750-302      Instruction Manual 

    X-PAD Software Package

    OPTIONAL
    47850 Combination Package 47650 Mouse RotaRod and 47750 Rat RotaRod

     

     

    See Additional Bibliography

    • L. Micheli et alia: “Acute and Subchronic Antinociceptive Effects Of Nociceptin/Orphanin Fq Receptor Agonists Infused by Intra­thecal Route in RatsEur. J. Pharmacol. 754 : 73-81, 2015
    • L. A. Griffiths et alia: “Knocking Down Metabotropic Glutamate Receptor 1 Improves Survival And Disease Progression in the SOD1G93A Mouse Model of Amyotrophic Lateral SclerosisJ. of Pain, accepted manuscript, 2015
    • l JV. Jokinen et alia: “Pregabalin Enhances the Antinociceptive Ef­fect of Oxycodone and Morphine in Thermal Models of Nocicep­tion in the Rat Without any Pharmacokinetic InteractionsEur. J. Pain DOI: 10.1002/ejp.728, 2015
    • l JF. Barthel et alia: “Long-term Application of Glycine Transpor­ter Inhibitors Acts Antineuropathic and Modulates Spinal N-methyl-D-aspartate Receptor Subunit NR-1 Expression in RatsAnesthesiology 121.1: 160-169, 2014
    • l C.D. Heldermon et alia: “Therapeutic Efficacy of Bone Marrow Transplant, Intracranial AAV-mediated Gene Therapy, or Both in the Mouse Model of MPS IIIBMolecular Therapy 15(5): 873-880, 2010 (rocking, mouse)
    • C.D. Heldermon et alia: “Development of Sensory, Motor & BehavioraDeficits in the Murine Model of Sanfilippo Syn­drome Type B”: PLoS ONE: 8 (e772): 2007 (rocking, mouse)

    • N.W. Dunham & T.S. Miya: “A Note on a Simple Apparatus for De­tecting Neurological Deficit in Rats & Mice“ J. Am. Pharmaceut. Assoc., Scientific Edit., XLVI: No. 3, 1957
    • B.J. Jones & D.J. Roberts: “The Quantitative Measurement of Mo­tor Incoordination in Naive Mice Using an Accelerating Rotarod“ J. Pharm. Pharmac.: 20: 302-304, 1968

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