Miscellaneous, ECT, LMD

53500 - Lesion Making Device

Lesion Making Device Lesion Making Device

The Ugo Basile Lesion Maker has been designed for the production of localized electrolytic lesions in small animals where DC is preferred to RF, to produce the lesion. 

It features a regulated power supply combined with a constant DC current generator which operates on either continuous or timed mode.

The current generator is protected against short circuit, which prevents the electronics to get damaged due to the electrodes coming accidentally in contact with each other.
 
Particular emphasis has been placed in the design of a good circuit output/ground insulation.
 
This feature, besides enhancing safe operation, minimizes spurious current field lines across the tissue, outside the pattern the operator has preset.
 

 

    FEATURES BENEFIT
    Current generator protected against short circuit Prevents damage to electronics, guarantees safety
    Wide current output range (10uA-99mA) and duration (1-99 s)

    Allows for virtually any procedure

    Three Operating Modes Continuous, Stand-by and Timed
    Violation LED indicator Indicates if compliance is violated

     

    Operation  
    Lesion Making Device DC Constant Current
    Current Range from 10 µA to 99 mA
    Compliance Voltage 200 V DC
    Max. Electrode Resistance 20 MOhm (10µA) down to 2 KOhm (100mA)
    Power Monitoring via red LED
    Current Monitoring via green LED
    Violation Monitoring via yellow LED
    Power Requirement 115 or 230 V, 50/60 Hz, 20 W max.
    Operating Temperature 10° to 40° C
    Sound Level <45dB
    Physical  
    Total Weight 1.4Kg
    Shipping Weight 3.7Kg approx.
    Dimensions 27(w)x25(d)x13(h)cm
    Packing Dimensions 45x34x26cm
    Warranty  
    Warranty 53500 is covered by a 24-month warranty.
    Operation  
    Lesion Making Device DC Constant Current
    Current Range from 10 µA to 99 mA
    Compliance Voltage 200 V DC
    Max. Electrode Resistance 20 MOhm (10µA) down to 2 KOhm (100mA)
    Power Monitoring via red LED
    Current Monitoring via green LED
    Violation Monitoring via yellow LED
    Power Requirement 115 or 230 V, 50/60 Hz, 20 W max.
    Operating Temperature 10° to 40° C
    Sound Level <45dB
    Physical  
    Total Weight 1.4Kg
    Shipping Weight 3.7Kg approx.
    Dimensions 27(w)x25(d)x13(h)cm
    Packing Dimensions 45x34x26cm
    Warranty  
    Warranty 53500 is covered by a 24-month warranty.

     

     

     

     

     

     

    D

    The surgically or electrically induced lesion has served as an important tool in the exper-imental search for function in the CNS. Its value has derived in part from the simplicity with which it can be used to study neural mechanisms of behaviour at a basic level.

    The advent of the stereotaxic technique, moreover, allowed researchers to produce dis-cretely placed lesions with consistency, especially in sub-cortical structures of the brain.

    The strength of the lesion technique resides also in the variety of ways with which to ap-ply it. Manipulating the type of lesion (DC, RF, knife cut, etc.), its size, the type of elec-trode, the angle of entry, and so on, should continue to expose critically important as-pects of neural functions because of the different effects that are produced.

    It is no coincidence that the history of the development of these techniques is closely tied to the recent history of theories regarding localization of function in the brain. The tradi-tional view, whose basic tenets are that (1) the functions are represented in discrete brain structures and that (2) the lesions disrupt function by removal of functional tissue in circumscribed sites, have been recently challenged by growing evidence of the importance of secondary changes.

    These are induced by a lesion, both directly (necrosis, anterograde and retrograde de-generation) and indirectly (transneuronal degeneration, regeneration and sprouting, al-teration of neurochemical pools, vascular disruption) and may comprise the more signifi-cal neurological changes which can account for alteration of behaviour in a lesion exper-iment.

    New strategy of research utilizing lesions is proposed, suggesting that greater emphasis be placed on the a posteriori assessment of secondary changes in the brain as they are correlated with changes in behaviour.

     

    53500 Lesion Making Device, complete with standard accessories
    53500-310 Set of 3 output plugs
    E-AU 041

    USB pen drive, including:  53500-302    Instruction Manual 

    Optional
    53500-322 Electrode for Lesion Making Device, stainless steel, diam. 0.3 mm, coated
    UE(KK1) Microelectrode SS Custom FHC

    See Additional Bibliography

    • V. Campese et alia: “Modulation of Instrumental Responding by a Conditioned Threat Stimulus Requires Lateral and Central AmygdalaFrontiers in Behav. Neurosc. 9(293), 2015
    • S.M. Fortin et alia: “Sampling Phasic Dopamine Signaling with Fast-Scan Cyclic Voltammetry in Awake, Behaving RatsCurrent Protocols in Neuroscience, UNIT 7.25, published online 5 Jan 2015
    • S.M. Fortin et alia: “Sampling Phasic Dopamine Signaling with Fast-Scan Cyclic Voltammetry in Awake, Behaving RatsCurrent Protocols in Neuroscience, UNIT 7.25, published online 5 Jan 2015
    • V.D. Campese et alia: “Lesions of lateral or central amygdala abolish aversive Pavlovian-to-instrumental transfer in ratsfront Behav Neurosci. 8: 161, 2014
    • M.G. McCue et alia: “Medial Amygdala Lesions Selectively Block Aversive Pavlovian–Instrumental Transfer in Ratsfront Behav Neurosci. 8: 329, 2014
    • Stroobants et alia: “PIncreased gait variability in mice with small cerebellar cortex lesions and normal rotarod performanceBehav. Brain Res. 241: 32-37, 2013
    • L.B. Cruz et alia: “Effect of the bone marrow cell transplantation on elevated plus-maze perfor­mance in hippocampal-injured miceBehav. Brain Res. available online Apr. 2013
    • M.E. Wang: “Long-Term Stabilization of Place Cell Remapping Produced by a Fearful Experience” J. Neurosci. 32(45): 15802-15814, 2012
    • M.B. Gomes et alia: “Glucose levels Observed in Daily Clinical Practice induce Endothelial Dy­sfunction in the Rabbit Macro- and Microcircula­tionFund. & Clin. Pharmacol. 18 (3), 2004
    • C. Hamani et alia: “Bilateral Anterior Thalamic Nucleus Lesions and High-frequency Stimula­tion Are Protective against Pilocarpine-induced Seizures and Status EpilepticusNeurosurgery, 54 (1): 191-197, 2004
    • T. Lee and J.J. Kim: “Differential Effects of Cere­bellar, Amygdalar, and Hippocampal Lesions on Classical Eyeblink Conditioning in RatsJ. Neuro­science 24 (13): 3242-3250, 2004
    • K.C. Bicego and L.G.S. Branco: “Discrete Electro­lytic lesion of the Preoptic Area Prevents LPS-Induced Behavioral Fever in ToadsJ. Exper. Biol. 205: 3513-3518, 2002

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