Behaviour, Mazes, Tracking

40142/3 - Elevated Plus Maze

Elevated Plus Maze Elevated Plus Maze

The elevated plus maze (EPM) was designed to measure anxiety in laboratory animals and as a general research tool in neurobiological anxiety research. The model is based on the test animal aversion to open spaces

All Animal Mazes manufactured by Ugo Basile are designed to give optimal results with any Video-Tracking software. This is achieved by:

  • high-contrast colors: grey, white, black or the NEW Ugo Basile light-blue
  • non-reflective surface: reflections are a common source of error in animal tracking. Let’s avoid them!

All materials were selected to be sturdy and easy to clean, to construct reliable and durable mazes. Surface texture was selected for best rodent comfort (reasonably rough, “warm” surface).

The mouse EPM, has four 5cm wide and 35cm long arms, two of which are open: the wall in the closed arms is 15cm high. In the rat model the four arems are 10cm wide and 50cm long, while the closed arms are 40cm tall. Height from the floor is 60cm for either model. The EPM is supported by 4 metal legs, which make the device very stable.

The closed arms can be quickly detached for easy cleaning and storage.

 

    FEATURE BENEFIT
    High-contrast colors Gives optimal results with any Video-Tracking software
    Non-reflecting surface Guarantees optimal camera view and no glare
    Ample color selection Available in grey (standard), blue, white, black, custom color
    Reasonably rough “warm” surface texture Selected for best rodent comfort, non-slippery
    Quality materials Reliable and durable mazes, easy to clean and store
    Physical 40142 Rat 40143 Mouse
    Open Corridor Length 110cm 80cm
    Closed Arm Length 50cm 35cm
    Corridor Width 10cm 5cm
    Closed Arm Height 40cm 15cm
    Height (from the floor) 60cm 60cm
    Standard color Grey (RAL GR5001)
    Available colors Blue, white, black, color on request
    Weight 15Kg 8Kg
    Shipping Weight 19Kg 10Kg
    Packing Dimensions 105x105x20cm 105x105x20cm
    Warranty 40142/3 is covered by a 24-month warranty

    The elevated plus-maze test is used as a rodent model of anxiety, and is representative of those tests that are based upon the study of spontaneous behaviour patterns. The model is based on the test animal's aversion to open spaces. In the EPM, this anxiety is expressed by the animal spending more time in the enclosed arms.

    The elevated plus maze is a widely used behavioral assay for rodents and it has been validated to assess the anti-anxiety effects of pharmacological agents and steroid hormones, and to define brain regions and mechanisms underlying anxiety-related behavior.

    Briefly, rats or mice are placed at the junction of the four arms of the maze, facing an open arm, and entries/duration in each arm are recorded by a video-tracking system and observer simultaneously for 5 min. Other ethological parameters (i.e., rears, head dips and stretched-attend postures) can also be observed.

    An increase in open arm activity (duration and/or entries) reflects anti-anxiety behavior.

    40142 Elevated Plus Maze (EPM) for Rats
    40143 Elevated Plus Maze (EPM) for Mice
      OPTIONAL
    60000 ANY-maze Software
    41700-040 B/W USB Camera, including day&night 2.7-13.5mm varifocal lens, 5m USB cable and ceiling support

    See Additional Bibliography

    • F. Vincenzi et alia: “Positive Allosteric Modulation of A1 Adenosine Receptors as a Novel and Promising Therapeutic Strategy for Anxiety” Neuropharmacology 111: 283-292, 2016
    • M. Przybyla et alia: “Disinhibition-like Behavior in a P301S Mutant Tau Transgenic Mouse Model of Frontotemporal Dementia” Neuroscience Letters 631: 24-29, 2016
    • Y. D. Ke et alia: "Short-term Suppression of A315T Mutant Human TDP-43 Expression Improves Functional Deficits in a Novel Inducible Transgenic Mouse Model of FTLD-TDP and ALS" Acta neuropathologica  130(5): 661-678, 2015

    • S. Pellow et alia: “Validation of Open:Closed Arm Entries in an Elevated Plus-Maze as a Measure of Anxiety in the Rat” J. Neuroscience methods 14(3): 149-167, 1985
    • D. Treit et alia: “Anxiogenic Stimuli in the Elevated Plus-Maze” Pharmacol. Biochemistry and Behavior 44(2): 463-469, 1993
    • R.J. Rodgers & A. Dalvi: “The use of the elevated plus maze as an assay of anxiety-related behavior in rodents” Neuroscience & Biobehavioral Reviews 21(6): 801-810, 1997
    • A.A. Wolf & Cheril A. Frye: “The Use of the Elevated Plus Maze as an Assay of Anxiety-Related Behavior in Rodents” Nature Protocols 2: 322-328, 2007

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