Behaviour, Mazes, Tracking

40803 - Forced Swim Test with Water Wheel Featured

Forced Swim Test with Water Wheel Forced Swim Test with Water Wheel

The NEW Forced Swim Test with Water Wheel automatically scores active escapes and eliminates the subjectivity of immobility measurements.

Automatically scored wheel rotations directly correspond to active escape attempts.

Although the Porsolt Forced Swim Test remains one of the most widely used behavioral test for screening antidepressants, the modification suggested by S. Nomura et alia in their paper of 1982 introduces an objective measurement, the number of rotations, as it involves a small water wheel set in a water tank, overcoming the bias intrinsic to Porsolt’s method. In fact, automatically scored wheel rotations directly correspond to active escape attempts.

“... this water wheel test is more appropriate as screening test for antidepressants than Porsolt’s test with regard to both objectivity and specificity.” (Nomura et al.)

In the habituation phase, the rodent is left for 5 minutes to explore the tank, and will identify the wheel as a possible escape way. The wheel rotates freely. During the test proper: mice turn the wheel vigorously and when they give up attempts to escape from the water, the wheel stops revolving and the number of rotations are recorded.

The FST 40803 includes rotation encoder & temperature sensor. The device connects to the PC via a USB cable provided as standard. up to 40 units can be connected to the same PC via a USB hub. A Forced Swim specific mode of ANY-maze (60000-FST), also included in the full license, collects the information from the electronics, automatically scores number of rotations and performs statistical analysis.

    FEATURE BENEFIT
    High Throughput Automate up to 40 tests, simultaneously
    Automated scoring of wheel rotations Eliminates subjectivity of immobility measurement
    Connection to PC via USB (or USB hub) Data collection and analysis via ANY-maze
    Temperature sensor included Continuous water temperature feedback
    General
    Power Supply USB (connection to PC)
    Scoring via rotation encoder (CW & CCW rotations)
    Temperature feedback Temperature sensor
    Data collection & analysis via ANYmaze FST module
    Operating Temperature 10° to 40°C
    Sound Level Negligible
    Pollution Degree ≤ 2
    Physical
    Dimensions 24(w)x12(d)x21(h)cm
    Weight 2,4Kg
    Shipping Weight 3.5Kg
    Packing Dimensions 29x26x29cm
    Warranty 40803 is covered by a 24-month warranty

    A depressed state can be induced in mice by forcing them to swim in a narrow cylinder from which they cannot escape. After a brief period of vigorous activity the mice adopt a characteristic immobile posture which is readily identifiable” (Porsolt et al.).

    In other words, mice forced to swim in a restricted space rapidly cease moving and become lethargic. Porsolt et al. named this phenomenon ‘behavioral despair’, and demonstrated that antidepressants selectively reduced the immobility. 

    The modification suggested by S. Nomura et alia in their paper of 1982 involves a small water wheel set in a water tank, to provide an objective measurement (number of rotations) and overcome the bias intrinsic to Porsolt’s method. 

    40803 Forced Swim Test, complete
    60000-FST ANYmaze Module for FST
    E-AU 041 USB pen-drive, including  
    40803-302      Instruction Manual   

    See Additional Bibliography

    • S. Nomura et alia: “A New Behavioral Test for AntiDepressant Drugs” Eur. J. Pharmacol. 83, 171-175, 1982
    • R.D. Porsolt et alia: “Behavioral Despair in Mice: A Primary Screening Test for Antidepressants” Arch. Intl. Pharmacodyn. 229(2), 327-336, 1977
    • R.G. Browne: “Effects of Antidepressants and Anti­cholinergics in a Mouse “Behavioral Despair” Test” Eur. J. Pharmacol. 58(3): 331–334, 1979

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