Behaviour, Conditioning, Reward

47500 - Learned Helplessness

Learned Helplessness Learned Helplessness

The Ugo Basile Set-Up for Learned Helplessness is based on a sophisticated generator of unpredictable random shocks delivered to the grid floor of a rodent box where no escape is possible. Electric shocks can be randomized in terms of shock length, interval and complex trains can be programmed.

When rodents are exposed to inescapable and unpredictable stress, such as forced swim or inescapable footshock, they often develop deficits in memory and learning tasks (e.g. Active Avoidance), and often show also analgesic reactions (S.I.A. Stress-Induced Analgesia).

At the core of the Learned Helplessness system is a dark isolation cube, in which the subject is placed, and a controller. The chamber is outfitted with an electrified grid floor, and connected to the controller which consists of a shock generator, as well as a timer that incorporates timing and randomizing. Shocks can be randomized on the basis of duration as well as by interval between shock events. Also, more complex trains of shocks can be programmed. The system includes a user-friendly reporting software, to collect, visualize and export into spreadsheets the delivered shocks.

The Learned Helplessness set-up is part of UB conditioning-cage project; you buy a single touch-screen controller, and manage all UB cages. Ask for details!

Mouse or Rat cages are available. This system is expandable, for stimulation of up to 4 animals simultaneously. 

The users owning Ugo Basile Fear Conditioning system can conduct the Learned Help-lessness test within the FC cages and cubicles, by purchasing and installing the LH soft-ware on their touch-screen controller

    FEATURES NEW ON THE 2014 VERSION!
    Part of the BEEHIVE SYSTEM the electronic unit encompasses all controls for up to 4 animal cages!
    Maximum Flexibility Configure your own Experimental Schedules on the touch-screen controller
    Randomizable shock pattern (length and interval) Shock trains can be programmed
    Remote Control feature Makes remote service and software upgrades extremely simple!
    Great Versatility The same controller can manage different conditioning tests. Ask for details!
    Touch Screen Controller
    LCD 12” with resistive touch screen
    CPU Module Port 2 USB Port 2.0; 1 Ethernet port 10/100Mb;1 DVI port for external monitor
    Peripheral Port 4 output for Sound, Shock and  light; 1 Power supply 12V-2A
    Expansion Bus         Connection 2 RJ11 connectors
    General
    Shock Constant current
    Shock Intensity from 0.1 to 2.9mA, in 0.1mA steps
    Shock Duration Duration: from 0 to 99 seconds
    Operating Temperature 10° to 40°C
    Sound Level Negligible
    Pollution Degree ≤ 2
    Number of Cages Up to 4 (with expansion boxes)
    Physical
    Dimensions

    25(d)x33(w)x5.5(h)cm (40500-001)

    22x22x20(h)cm (47502)

    17x17x20(h)cm (47503)

    Weight

    2.7Kg (40500-001)

    5.3 (40532)  

    3.4 (40533)  

    Shipping Weight

    Rat Set-Up      13Kg

    Mouse Set-Up 12Kg

    Packing Dimensions 80x60x44cm (Control Unit & one cage)
    Warranty 47500 is covered by a 24-month warranty

    Learned helplessness is behavior typical of an organism (human or animal) that has endured repeated painful or otherwise aversive stimuli which it was unable to escape or avoid: American psychologist Martin Seligman initiated research on learned helplessness in 1967 at the University of Pennsylvania as an extension of his interest in depression.

    In animal studies, when rodents are exposed to inescapable and unpredictable stress, such as forced swim or inescapable footshock, they often develop deficits in memory and learning tasks (e.g. Active Avoidance), and they often show also analgesic reactions (S.I.A. Stress-Induced Analgesia).

    In addition, psychologists have looked at the correlation of depression and anxiety with learned helplessness over the years. It has been shown that the symptoms shown with learned helplessness have corresponding symptoms in depression. The symptoms most felt when depressed are the feelings of helplessness and uncontrollability that have been correlated with learned helplessness.

    Helplessness behavior is also studied in social settings: being repeatedly exposed to uncomfortable or painful situations, the person may believe that there is no use in trying to evade such situations. Another example of learned helplessness in social settings involves loneliness and shyness. Those who are extremely shy, passive, anxious and depressed may learn helplessness to offer stable explanations for unpleasant social experiences

    SET-UP FOR LEARNED HELPLESSNESS, RAT
    40500-001 Controller with Touch Screen and 8-pole Scrambling Shocker
    47500-010 Software and activation for Learned Helplessness Test
    47502 Rat Cage for Learned Helplessness
    52010-323 USB Cable
    E-AU 041 USB pen-drive, including
    47500-302      Instruction Manual 
    SET-UP FOR LEARNED HELPLESSNESS, MOUSE
    40500-001 Controller with Touch Screen and 8-pole Scrambling Shocker
    47500-010 Software and activation for Learned Helplessness Test
    47503 Mouse Cage for Learned Helplessness
    52010-323 USB Cable
    E-AU 041 USB pen-drive, including
    47500-302      Instruction Manual 

    MULTIPLE-CAGE SET-UP

    The following is an example of configuration of a 4-Cage Mouse set-up:

    1 40500-001 Controller with Touch Screen and 8-pole Scrambling Shocker
    47500-010 Software and activation
    4 47503 A.A. Mouse Cage
    3 40500-005 Expansion Box (one is required for each additional cage)
    • K. Szklarczyk et alia: “Endogenous opioids regulate glucocorticoid-dependent stress-coping strategies in miceNeuroscience 330: 121-137, 2016
    • K. Szklarczyk et alia: “Opioid-Dependent Regulation of High and Low Fear Responses in two Inbred Mouse StrainsBehav. Brain Res 292: 95-101, 2015
    • Kademian et alia: “Biphasic effects of adrenal steroid on learned helplessness behavior by inescapable shockNeuropsychopharmacology 30: 58-66, 2005
    • Guilherme dos Santos et alia: “Antidepressive-like effects of electroacupuncture in ratsPhysiology & Behavior 93: 155-159, 2008
    • S.R. Lourenço Joca et alia: “Activation of post-synaptic 5-HT1A receptors in the dorsal hippocampus prevents learned helplessness developmentBrain Research 978 (1-2): 177-184, 2003
    • Borsini & Cesana: “Mechanisms of action of flibanserin in the learned helplessness in ratsEuropean Journal of Pharmacology 433: 81-89, 2001
    • W.H. Freeman: “Helplessness: On Depression, Development, and Death” ISBN 0-7167-0752-7. (Paperback reprint edition, W.H. Freeman, 1992, ISBN 0-7167-2328-X)
    • Grau et alia: “Long-term analgesia and activation of the opiate system” Science 213:1409-1411, 1981

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