Behaviour, Conditioning, Reward

42552/3 - Conditioned Place Preference (CPP) Cages Featured

Conditioned Place Preference (CPP) Cages Conditioned Place Preference (CPP) Cages

The new Ugo Basile Conditioned Place Preference (CPP) cage is a 2-compartment box to evaluate the abuse potential of substances and the motivational effects of drugs in mice or rats. 

The box includes the contextual cues required by the experimental paradigm:

  • 4 interchangeable floors with square or circular patterns
  • 3 sets of walls

The new CPP box has been designed and optimized for use with any video-tracking software or visual scoring.

The 2 compartments differ for the walls colour and patterns and for the floor patterns and texture. 
 
Both the floors and the wall contexts are interchangeable so that the visual and tactile difference between the 2 compartments can be easily adjusted by the scientist: replaceing the walls is quick and easy, hence on request we can provide customized sets of walls, with different pattern or texture.
    FEATURE BENEFIT
    Interchangeable patterned floors and walls The two compartments differ by tactile stimulation
    Walls in either compartment can be altered, by replacing the context kit The two compartments differ by visual stimulation
    High contrast with light or dark animals Optimized for Video-Tracking
    Specific models and floors for rats or mice Designed for multiple-cage systems
    Physical
    Dimensions

    42552 Rat Cage:      60(w)x30(d)x30(h)cm

    42553 Mouse Cage: 32(w)x15(d)x25(h)cm

    Patterned Floors 4 interchangeable floors for each cage
    Context Walls 3 interchangeable context kits provided with each cage
    Shipping Weight

    42552 Rat Cage:      22Kg

    42553 Mouse Cage: 10Kg

    Packing Dimensions

    42552 Rat Cage:      80x46x56cm

    42553 Mouse Cage: 36x55x45cm

    Warranty 42552/3 is covered by a 24-month warranty

    The CPP paradigm provides information on the rewarding or aversive effects of visible and tactile contextual cues associated with drugs. 

    This technique has acquired great popularity in research studies involving addiction, being much easier, if compared to drug self-administration procedures. 

    First, the animal is conditioned to identify one of the two compartments with the drug experience. Then the time spent in each compartments is measured; preference or
    aversion to the drug-paired compartment, hence rewarding/aversive properties of drugs, can be easily deducted.

    The CPP test only requires the animal to carry out a simple operation (i.e. move from one compartment to the other) to approach or avoid the drug-paired compartment; the animal is expected to spend more time in the drug-paired compartment, if the drug experience produced a positive effect.

     

     

    42503 CPP BOX for RAT, complete
    M-TR 230-F Floor Drawer (2 pcs. are provided)
    42503-011 Round 2mm holes, 6mm interax. (2 pcs.)
    42503-012 Round 12mm holes, 16mm interax. (2 pcs.)
    42503-014 Square 6x6mm holes, 9mm interax. (2 pcs.)
    42503-013 Square 10x10mm holes, 12mm interax. (2 pcs.)
    42552-320 Wall Context Kit for Rat Cage
    42503 CPP BOX for MOUSE, complete
    M-TR 238-F Floor Drawer (2 pcs. are provided)
    42503-011 Round 2mm holes, 6mm interax. (2 pcs.)
    42503-012 Round 12mm holes, 16mm interax. (2 pcs.)
    42503-014 Square 6x6mm holes, 9mm interax. (2 pcs.)
    42503-013 Square 10x10mm holes, 12mm interax. (2 pcs.)
    42553-320 Wall Context Kit for Rat Cage
    • L. Fattore et alia: “Baclofen Prevents Drug-Induced Reinstatement of Extinguished Nicotine-Seeking Behaviour and Nicotine Place Preference in RodentsEur. European Neuropsychopharmacol. 19(7): 487-498, 2009
    • M. Scherma et alia: “Inhibition of Anandamide Hydrolysis by Cyclohexyl Carbamic Acid 3’-Carbamoyl-3-yl Ester (URB597) Reverses Abuse-Related Behavioral and Neuro-chemical Effects of Nicotine in RatsJ. Pharmacol. and Exper. Therap.” 327:482–490, 2008

    Special thanks to Prof. Paola Fadda (Department of Pharmacology, University of Cagliari, Italy) for the initial design of the boxes: her valuable comments and suggestions allowed us to keep the focus on the user needs and opinions.

    See Additional Bibliography

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