Behaviour, Conditioning, Reward

48000 - Startle/PPI Test Featured

Startle/PPI Set-Up for Mice Startle/PPI Set-Up for Mice

Our STARTLE/PPI System allows automatic detection of Startle Reflex in Mice. 

The Startle/PPI set-up is part of UB conditioning-cage project; you buy a single touch-screen controller, and manage all UB cages. Ask for details!

Depending on the number of cages, different set-ups can be obtained by combining a controller with Dedicated Software on board, with a Startle Link-Box and up to 4 Isolation Cubicles and Stimulating/Recording Platforms, each including two different Animal boxes (NO HOLDER). Multiple-cage set-ups require expansion-cubicle/s with slave electronics on board.

On the Controller 12” touch-screen, the operator sets Sound and Light parameters via the user-friendly interface. Trials can be configured by defining trial number, acoustic/visual stimulus and timing of the different experimental sequences (all fully randomizable): 

  • Pulse
  • Prepulse
  • Inter-Pulse Interval
  • Inter-Stimulus Interval

The Stimulating/Recording Platform is the core of the set-up, encompassing the box where the mouse is placed, the light and the speaker, which deliver the startling stimuli (pulses), and the detection system. Two Mouse Boxes are provided as standard:

  • 48000-320 Small Mouse Box: ID 84x34x39(h)mm
  • 48000-320 Large Mouse Box: ID 84x39x44(h)mm

A Startle-Link Box collects the signals from up to 4 Stimulating/Recording Platforms and sends them to the Controller.

The new-design Isolation Cubicle 46000-590 includes an I.R. light, a loudspeaker and a noiseless fan, all conveniently positioned inside the sound attenuating box.

    FEATURES NEW ON THE 2014 VERSION!
    Part of the BEEHIVE SYSTEM the electronic unit encompasses all controls for up to 4 animal cages!
    Maximum Flexibility, full event randomization Configure your own Experimental Schedules on the touch-screen controller
    Remote Control feature Makes remote service and software upgrades extremely simple!
    Great Versatility The same controller can manage different conditioning tests. Ask for details!
    Touch Screen Controller
    LCD 12” with resistive touch screen
    CPU Module Port 2 USB Port 2.0; 1 Ethernet port 10/100Mb;1 DVI port for external monitor
    Peripheral Port 4 output for Sound, Shock and  light; 1 Power supply 12V-2A
    Expansion Bus         Connection 2 RJ11 connectors
    General
    Sound Pulse : in the range 100Hz-18KHz; 60-120dB
    Prepulse : 100Hz-18KHz; 60-120dB
    White-Noise : 60-80dB
    Light IR Light : 0-100% (Environment)
    Flash Light : 0-100% (20K Lux) S/R Platform)
    Operating Temperature 10° to 40°C
    Sound Level Negligible
    Pollution Degree ≤ 2
    Number of Cages Up to 4 (with expansion boxes)
    Physical
    Dimensions

    25(d)x33(w)x5.5(h)cm (40500-001)

    48000-320 Small Mouse Box: ID 84x34x39(h)mm

    48000-320 Large Mouse Box: ID 84x39x44(h)mm

    Weight 2.7Kg (40500-001)
    Shipping Weight Mouse Single-Cage Set-Up   40Kg
    Packing Dimensions 82x71x57cm (wooden crate) for a Mouse Single-Cage Set-up
    Warranty 48000 is covered by a 24-month warranty

    In animals, including humans, the startle response is a largely unconscious defensive response to sudden or threatening stimuli, such as sudden noise or sharp movement, and is associated with negative effect. Usually the onset of the startle response is a startle reflex reaction, a brainstem reflectory reaction (reflex) that serves to protect vulnerable parts, such as the back of the neck (whole-body startle) and the eyes (eyeblink) and facilitates escape from sudden stimuli.

    Prepulse Inhibition (PPI) is a neurological phenomenon in which a weaker prestimulus (prepulse) inhibits the reaction of an organism to a subsequent strong startling stimulus (pulse). The stimuli are usually acoustic, but tactile stimuli (e.g. via air puffs on the skin) and light stimuli are also used.
    The reduction of the amplitude of startle reflects the ability of the nervous system to temporarily adapt to a strong sensory stimulus when a preceding weaker signal is given to warn the organism.

    Deficits of prepulse inhibition, manifesting in the inability to filter out the unnecessary information, have been linked to abnormalities of sensorimotor gating, noted in patients suffering from illnesses like Schizophrenia and Alzheimer’s Disease, or under the influence of drugs, surgical manipulations, or mutations. Animal models are widely used to test hypotheses linking genetic components of various diseases with sensorimotor gating.

    48153 STARTLE/PPI SYSTEM FOR MICE, single cage system
    40500-001

    Controller with Touch Screen and 8-pole Scrambling Shocker

    48000-010 Software and activation

    48005 Stimulating/Recording Platform for Mouse
    48000-320 Small Mouse Box
    48000-322 Large Mouse Box
    48000-100 Startle link-box
    46000-590 Isolation Cubicle, sound attenuation box with IR Light, loudspeaker, noiseless fan
    52010-323 USB pen-drive, including
    48000-302      Instruction Manual 

    MULTIPLE-CAGE SET-UP

    48253 STARTLE/PPI SYSTEM FOR MICE, two-cage system
    1 40500-001

    Controller with Touch Screen and 8-pole Scrambling Shocker

    48000-010 Software and activation

    2 48005 Stimulating/Recording Platform for Mouse
    2 48000-320 Small Mouse Box
    2 48000-322 Large Mouse Box
    1 48000-100 Startle link-box
    2 46000-590 Isolation Cubicle, sound attenuation box with IR Light, loudspeaker, noiseless fan
    1 52010-323 USB pen-drive, including
    48000-302      Instruction Manual 
    48453 STARTLE/PPI SYSTEM FOR MICE, four-cage system
    1 40500-001

    Controller with Touch Screen and 8-pole Scrambling Shocker

    48000-010 Software and activation

    4 48005 Stimulating/Recording Platform for Mouse
    4 48000-320 Small Mouse Box
    4 48000-322 Large Mouse Box
    1 48000-100 Startle link-box
    4 46000-590 Isolation Cubicle, sound attenuation box with IR Light, loudspeaker, noiseless fan
    1 52010-323 USB pen-drive, including
    48000-302      Instruction Manual 

    See Additional Bibliography

    • M. Koch: “The Neurobiology of Startle” Prog Neuro­biol. 59(2):107-28, 1999
    • D. Braff et alia: “Human Studies of Prepulse Inhibition of Startle: Normal Subjects, Patient Groups, and Phar­macological Studies” Psychopharmacology 156(2): 234-258., 2001
    • H.S. Hoffman et al.: “Startle Reaction: Modification By Background Acoustic Stimulation” Science 141: 928-30, 1963
    • R.R. Marsh et alia: “The Role of Small Changes in the Acoustic Environment in Modifying the Startle Reflex” J Exp Psychol Anim Behav Process, 1(3): 1975

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